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Invasion und Metastasierung
Dieses Kapitel beschreibt Prozesse, Moleküle und Wechselwirkungen, die zur Invasion und Metastasierung beitragen, die am stärksten definierenden...
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Invasion and Metastasis
This chapter delineates processes, molecules, and interactions contributing to invasion and metastasis, the most defining properties of malignancy....
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PTEN-restoration abrogates brain colonisation and perivascular niche invasion by melanoma cells
BackgroundMelanoma brain metastases (MBM) continue to be a significant clinical problem with limited treatment options. Highly invasive melanoma...
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Targeting cholesterol impairs cell invasion of all breast cancer types
BackgroundBreast cancer clinical outcome relies on its intrinsic molecular subtype and mortality is almost exclusively due to metastasis, whose...
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Neural Influence on Cancer Invasion and Metastasis
Nerves modulate the surrounding tissue to facilitate nerve repair and regeneration. This fascinating regenerative ability is demonstrated in case of...
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PLK1 phosphorylates RhoGDI1 and promotes cancer cell migration and invasion
BackgroundRho guanine nucleotide dissociation inhibitor 1 (RhoGDI1) plays an important role in diverse cellular processes by regulating Rho guanosine...
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TRIM8 Promotes Proliferation, Invasion, and Migration of Cervical Cancer Cells by Ubiquitinating and Degrading SOCS1
Cervical cancer (CC) is a malignant tumor primarily caused by the persistent infection with high-risk strains of human papillomavirus. This study...
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The depth of perineural invasion is an independent prognostic factor for stage II colorectal cancer
BackgroundPerineural invasion (PNI) is the invasion of nerves by cancer cells and is associated with poor survival in stage II colorectal cancer....
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The prognostic value of separate lymphatic invasion and vascular invasion in oesophageal squamous cell carcinoma: a meta-analysis and systematic review
BackgroundLymphovascular invasion (LVI) is a factor correlated with a poor prognosis in oesophageal squamous cell carcinoma (ESCC). Lymphatic...
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Invasion and Metastatic Potential of Cancer Stem Cells In Vitro
In order to fight against cancer, it is critical to study cellular migration, invasion, and adhesion, which are the pivotal steps of metastasis....
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Modeling Collective Invasion and Single-Cell Mesenchymal Invasion in Three-Dimensional Matrigel–Collagen I Cultures
Understanding the modes and mechanisms of tumor cell invasion is key to develo** targeted therapies against metastatic disease. In vitro assays...
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CD57 defines a novel cancer stem cell that drive invasion of diffuse pediatric-type high grade gliomas
BackgroundDiffuse invasion remains a primary cause of treatment failure in pediatric high-grade glioma (pHGG). Identifying cellular driver(s) of pHGG...
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The Long Non-Coding RNA ENST00000494165 Influence Papillary Thyroid Cancer Cell Proliferation and Invasion
Long noncoding RNAs (lncRNAs) have recently been identified as crucial biomarkers of papillary thyroid cancer (PTC). In this study, we aimed to...
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EZH2 Promotes Glioma Cell Proliferation, Invasion, and Migration via Mir-142-3p/KCNQ1OT1/HMGB3 Axis
This study investigates the role and molecular mechanism of EZH2 in glioma cell proliferation, invasion, and migration. EZH2, miR-142-3p, lncRNA...
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KCNA1 promotes the growth and invasion of glioblastoma cells through ferroptosis inhibition via upregulating SLC7A11
BackgroundThe high invasiveness and infiltrative nature of Glioblastoma (GBM) pose significant challenges for surgical removal. This study aimed to...
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Classification of IDH wild-type glioblastoma tumorspheres into low- and high-invasion groups based on their transcriptional program
BackgroundGlioblastoma (GBM), one of the most lethal tumors, exhibits a highly infiltrative phenotype. Here, we identified transcription factors...
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The prognostic role of single cell invasion and nuclear diameter in early oral tongue squamous cell carcinoma
BackgroundThe clinical significance of single cell invasion and large nuclear diameter is not well documented in early-stage oral tongue squamous...
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5ʹ-Ectonucleotidase CD73/NT5E supports EGFR-mediated invasion of HPV-negative head and neck carcinoma cells
BackgroundEpithelial-to-mesenchymal transition (EMT) of malignant cells is a driving force of disease progression in human papillomavirus-negative...
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Molecular and Cellular Mechanism of Pathogen Invasion into the Central Nervous System: Meningitis
Meningitis, a deadly ailment that affects the central nervous system (CNS), involves the inflammation of the brain and spinal cord’s protective...
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Preoperative assessment of peripheral vascular invasion of pancreatic ductal adenocarcinoma based on high-resolution MRI
ObjectivesPreoperative imaging of vascular invasion is important for surgical resection of pancreatic ductal adenocarcinoma (PDAC). However, whether...
