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Intranasal and Inhaled Vaccines
Many respiratory infections have epidemic and pandemic potential, as evidenced by influenza and the recent COVID-19 pandemic. Vaccination is an...
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Intranasal Pressure Recording for Monitoring Mouse Respiration
Respiration is a highly dynamic signal that influences voluntary behaviors including odor sampling and entrains rhythmic activity in the brain. Many...
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Intranasal insulin effect on cognitive and/or memory impairment: a systematic review and meta-analysis
Background: Cognitive impairment, characterized by deficits in cognitive functions and loss of delayed and immediate recall, disproportionately...
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Nanovesicular-Mediated Intranasal Drug Therapy for Neurodegenerative Disease
Numerous neurodegenerative conditions, such as Alzheimer’s, Huntington’s, Parkinson’s, amyotrophic lateral sclerosis, and glioblastoma multiform are...
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Post-exposure intranasal IFNα suppresses replication and neuroinvasion of Venezuelan Equine Encephalitis virus within olfactory sensory neurons
BackgroundVenezuelan Equine Encephalitis virus ( VEEV) may enter the central nervous system (CNS) within olfactory sensory neurons (OSN) that...
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In-depth Mechanism, Challenges, and Opportunities of Delivering Therapeutics in Brain Using Intranasal Route
Central nervous system-related disorders have become a continuing threat to human life and the current statistic indicates an increasing trend of...
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Intranasal Monophosphoryl Lipid a Administration Ameliorates depression-like Behavior in Chronically Stressed Mice Through Stimulation of Microglia
We and others have reported that systematic stimulation of the central innate immune system by a low dose of lipopolysaccharide (LPS) can improve...
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Intranasal delivery of mitochondria targeted neuroprotective compounds for traumatic brain injury: screening based on pharmacological and physiological properties
Targeting drugs to the mitochondrial level shows great promise for acute and chronic treatment of traumatic brain injury (TBI) in both military and...
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Intranasal delivery of siRNA targeting NR2B attenuates cancer-associated neuropathic pain
PurposeThis study aimed to reduce cancer-associated pain by blocking pain signals through the intranasal administration of siRNA targeting the NMDA...
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Significance of Intranasal Drug Delivery Systems: Recent Trends and Clinical Investigations in Brain Disorders
Intranasal drug administration has enormous research potential, including both drugs designed specifically for intranasal use and off-label...
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Intranasal inorganic cerium oxide nanoparticles ameliorate oxidative stress induced motor manifestations in haloperidol-induced parkinsonism
Cerium oxide nanoparticles (CONPs), owing to their radical scavenging property, have recently emerged as a therapeutic candidate for oxidative...
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Intranasal vaccination with an NDV-vectored SARS-CoV-2 vaccine protects against Delta and Omicron challenges
The rapid development and deployment of vaccines following the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been...
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Re-examining Naloxone Pharmacokinetics After Intranasal and Intramuscular Administration Using the Finite Absorption Time Concept
Background and ObjectivesNaloxone for opioid overdose treatment can be administered by intravenous injection, intramuscular injection, or intranasal...
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The Synergistic Effect Study of Lipopolysaccharide (LPS) and A53T-α-Synuclein: Intranasal LPS Exposure on the A53T-α-Synuclein Transgenic Mouse Model of Parkinson’s Disease
Aging and interactions between genetic and environmental factors are believed to be involved the chronic development of Parkinson’s disease (PD)....
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Nanoemulsions and nanocapsules as carriers for the development of intranasal mRNA vaccines
The global emergency of coronavirus disease 2019 (COVID-19) has spurred extensive worldwide efforts to develop vaccines for protection against severe...
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Phase III Pivotal comparative clinical trial of intranasal (iNCOVACC) and intramuscular COVID 19 vaccine (Covaxin®)
One of the most preferable characteristics for a COVID-19 vaccine candidate is the ability to reduce transmission and infection of SARS-CoV-2, in...
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Intranasal administration of Lactobacillus johnsonii attenuates hyperoxia-induced lung injury by modulating gut microbiota in neonatal mice
BackgroundSupplemental oxygen impairs lung development in newborn infants with respiratory distress. Lactobacillus johnsonii supplementation...
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The Effect of Intranasal Administration of Gangliosides on the Viability of CA1 Hippocampal Neurons in Rat Two-Vessel Occlusion Model of Forebrain Ischemia/Reperfusion Injury
Intranasal administration of total bovine brain gangliosides (6 mg/kg) to rats protected the CA1 hippocampal neurons from the death caused by...
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Intranasal vaccine for Lyme disease provides protection against tick transmitted Borrelia burgdorferi beyond one year
Strategies for disease control are necessary to reduce incidence of Lyme Disease (LD) including development of safe vaccines for human use....
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Stem Cell Therapy for Ischemic Brain Injury: Early Intranasal Delivery after Cardiac Arrest
Global ischemic brain injury is the leading cause of mortality and long-term disability in patients resuscitated from cardiac arrest. Hypothermia and...