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Lipid Nanoparticle-Enabled Intracellular Delivery of Prime Editors
Prime editing is an advanced gene editing platform with potential to correct almost any disease-causing mutation. As genome editors have evolved,...
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Meta-Analysis of Drug Delivery Approaches for Treating Intracellular Infections
This meta-analysis aims to evaluate the trend, methodological quality and completeness of studies on intracellular delivery of antimicrobial agents....
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pH-sensitive liposomes bearing a chemotherapeutic agent and a natural apoptosis modulator for effective intracellular delivery to the solid tumor
The intracellular delivery of the drug to the solid tumor is a major challenge in the treatment of solid tumors. This project aims to increase...
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Microfluidic Approaches for Gene Delivery and Therapy
Gene editing techniques such as Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR/Cas9) have been developed to target a gene into...
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Intracellular delivery of Parkin-RING0-based fragments corrects Parkin-induced mitochondrial dysfunction through interaction with SLP-2
BackgroundLoss-of-function mutations in the PRKN gene, encoding Parkin, are the most common cause of autosomal recessive Parkinson’s disease (PD)....
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Intracellular Compartments and Drug Resistance
Intracellular compartments play a pivotal role in cellular function, housing diverse organelles that contribute to essential processes such as...
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Connexin-Containing Vesicles for Drug Delivery
Connexin is a transmembrane protein present on the cell membrane of most cell types. Connexins assemble into a hexameric hemichannel known as...
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Inter- and Intracellular Signaling Pathways
Cardiovascular diseases, both congenital and acquired, are the leading cause of death worldwide, associated with significant health consequences and...
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The intracellular visualization of exogenous DNA in fluorescence microscopy
In the development of non-viral gene delivery vectors, it is essential to reliably localize and quantify transfected DNA inside the cell. To track...
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RNA Nanomedicine: Delivery Strategies and Applications
Delivery of RNA using nanomaterials has emerged as a new modality to expand therapeutic applications in biomedical research. However, the delivery of...
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Nanocarriers: Delivery Routes
Nanocarriers have crucial applications in medicine, mainly in drug delivery. The choice of administration route assumes significance during the drug...
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Dendrimers-Mediated Delivery of Phytoconstituents
The potential for dendrimers, highly branching three-dimensional macromolecules, to function as drug delivery vehicles has been extensively...
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Pulmonary Delivery of Nucleic Acids
Pulmonary diseases affect millions of people worldwide and elicit symptoms that may evolve into severe conditions. Despite currently recommended...
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Polymeric nanoparticles delivery circumvents bacterial resistance to ciprofloxacin
ObjectiveThe efficient inhibition of bacteria and their by-products from infected root canals is hampered by the limitations of traditional root...
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Oral delivery of RNAi for cancer therapy
Cancer is a major health concern worldwide and is still in a continuous surge of seeking for effective treatments. Since the discovery of RNAi and...
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Drug Delivery in Biotechnology: Present and Future
Nanobiotechnology is the integration of nanotechnology with biotechnology, with a specific emphasis on the utilisation of nanoscale techniques in...
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The effects of intracellular and exosomal ncRNAs on cancer progression
Altered gene expression as well as mislocalization of a gene’s encoded product (proteins or noncoding RNAs (ncRNAs)) can lead to disease and cancer...
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Gastrointestinal Delivery of an mRNA Vaccine Using Immunostimulatory Polymeric Nanoparticles
mRNA vaccines can be translated into protein antigens, in vivo , to effectively induce humoral and cellular immunity against these proteins. While...
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Subcellular trafficking and transcytosis efficacy of different receptor types for therapeutic antibody delivery at the blood‒brain barrier
Here, we report an experimental setup to benchmark different receptors for targeted therapeutic antibody delivery at the blood–brain barrier. We used...
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Polymeric Nanocarriers for the Delivery of Phytoconstituents
In past decades, with the advent of nanotechnology, nanocarriers have been highlighted as promising drug delivery systems for therapeutic,...