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Quantitative Analysis of Intracellular Drug Concentrations in Hepatocytes
Knowledge of intracellular drug concentrations in hepatocytes is fundamentally important for understanding and predicting drug efficacy, toxicity,...
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Intracellular Compartments and Drug Resistance
Intracellular compartments play a pivotal role in cellular function, housing diverse organelles that contribute to essential processes such as...
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Intracellular Ca2+ Regulation
A plethora of cellular functions including vasoconstriction and vasodilatation are regulated by calcium (Ca2+) ion and the cytosolic Ca2+...
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Inter- and Intracellular Signaling Pathways
Cardiovascular diseases, both congenital and acquired, are the leading cause of death worldwide, associated with significant health consequences and...
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The role of soluble adenylyl cyclase in sensing and regulating intracellular pH
Soluble adenylyl cyclase (sAC) differs from transmembrane adenylyl cyclases (tmAC) in many aspects. In particular, the activity of sAC is not...
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Role of TPEN in Amyloid-β25–35-Induced Neuronal Damage Correlating with Recovery of Intracellular Zn2+ and Intracellular Ca2+ Overloading
The overproduction of neurotoxic amyloid-β (Aβ) peptides in the brain is a hallmark of Alzheimer’s disease (AD). To determine the role of...
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Detection of Intracellular Complement Activation by Nanoparticles in Human T Lymphocytes
The complement system is complex and includes two main components: the systemic or plasma complement and the so-called intracellular complement or...
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Intracellular galectin interactions in health and disease
In the galectin family, a group of lectins is united by their evolutionarily conserved carbohydrate recognition domains. These polypeptides play a...
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Extracellular and Intracellular Recordings
This chapter explores extracellular (multi-cell recordingMulti-cell recording and cell-attached patchCell-attached patch) and intracellular recording...
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Carnosine regulation of intracellular pH homeostasis promotes lysosome-dependent tumor immunoevasion
Tumor cells and surrounding immune cells undergo metabolic reprogramming, leading to an acidic tumor microenvironment. However, it is unclear how...
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A Population Pharmacokinetic Model of Whole-Blood and Intracellular Tacrolimus in Kidney Transplant Recipients
Background and ObjectiveThe tacrolimus concentration within peripheral blood mononuclear cells may correlate better with clinical outcomes after...
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Caveolin-1 deficiency alleviates palmitate-induced intracellular lipid accumulation and inflammation in pancreatic β cells
Lipotoxicity-induced pancreatic β cell damage is a strong predictor of type 2 diabetes mellitus (T2DM). Our previous work showed that Caveolin-1...
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Phosphoinositides and intracellular calcium signaling: novel insights into phosphoinositides and calcium coupling as negative regulators of cellular signaling
Intracellular calcium (Ca 2+ ) and phosphoinositides (PIPs) are crucial for regulating cellular activities such as metabolism and cell survival. Cells...
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Intracellular DAMPs in Neurodegeneration and Their Role in Clinical Therapeutics
Neuroinflammation is the major implication of neurodegeneration. This is a complex process which initiates from the cellular injury triggering the...
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The intracellular visualization of exogenous DNA in fluorescence microscopy
In the development of non-viral gene delivery vectors, it is essential to reliably localize and quantify transfected DNA inside the cell. To track...
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ZSWIM4 inhibition improves chemosensitivity in epithelial ovarian cancer cells by suppressing intracellular glycine biosynthesis
BackgroundZinc finger SWIM-type containing 4 (ZSWIM4) induces drug resistance in breast cancer cells. However, its role in epithelial ovarian cancer...
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Candesartan, an angiotensin-II receptor blocker, ameliorates insulin resistance and hepatosteatosis by reducing intracellular calcium overload and lipid accumulation
Insulin resistance is a major contributor to the pathogenesis of several human diseases, including type 2 diabetes, hypertension, and hyperlipidemia....
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Thinking inside the box: intracellular roles for complement system proteins come into focus
Over the last decade, perspectives on the complement system in the context of cancer have shifted, with complement proteins now implicated in many of...
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Meta-Analysis of Drug Delivery Approaches for Treating Intracellular Infections
This meta-analysis aims to evaluate the trend, methodological quality and completeness of studies on intracellular delivery of antimicrobial agents....
