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Intra-specific copy number variation of MHC class II genes in the Siamese fighting fish
Duplicates of genes for major histocompatibility complex (MHC) molecules can be subjected to selection independently and vary markedly in their...
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Sex-specific morphs: the genetics and evolution of intra-sexual variation
Sex-specific morphs exhibit discrete phenotypes, often including many disparate traits, that are observed in only one sex. These morphs have evolved...
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Intra- and interspecies variation and population dynamics of Fasciola gigantica among ruminants in Sudan
Fasciola gigantica is a widespread parasite that causes neglected disease in livestock worldwide. Its high transmissibility and dispersion are...
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Bungarus fasciatus venom from eastern and north-east India: venom variation and immune cross-reactivity with Indian polyvalent antivenoms
Bungarus fasciatus is one of the medically important elapid snakes of South and South-eastern Asia and is responsible for several snakebite incidents...
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Variation of tafamidis plasma levels during the treatment of TTR amyloidosis patients with Glu89Gln mutation
PurposeThe transthyretin kinetic stabilizer tafamidis, used as a first-line therapy of amyloidosis patients, binds selectively to the transthyretin...
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Intragenomic rDNA variation - the product of concerted evolution, mutation, or something in between?
The classical model of concerted evolution states that hundreds to thousands of ribosomal DNA (rDNA) units undergo homogenization, making the...
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Gut microbiota response to in vitro transit time variation is mediated by microbial growth rates, nutrient use efficiency and adaptation to in vivo transit time
BackgroundTransit time is an important modulator of the human gut microbiome. The inability to modify transit time as the sole variable hampers...
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Genetic variation at innate and adaptive immune genes – contrasting patterns of differentiation and local adaptation in a wild gull
Immunogenetic variation in natural vertebrate populations is expected to respond to spatial and temporal fluctuations in pathogen assemblages. While...
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Complete sources of cluster variation on the risk of under-five malaria in Uganda: a multilevel-weighted mixed effects logistic regression model approach
BackgroundMalaria, a major cause of mortality worldwide is linked to a web of determinants ranging from individual to contextual factors. This calls...
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Resolving haplotype variation and complex genetic architecture in the human immunoglobulin kappa chain locus in individuals of diverse ancestry
Immunoglobulins (IGs), critical components of the human immune system, are composed of heavy and light protein chains encoded at three genomic loci....
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Genetic variation of E6 and E7 genes of human papillomavirus type 16 from central China
BackgroundPersistent high-risk human papillomavirus (HR-HPV) infection is an important factor in the development of cervical cancer, and human...
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Population history modulates the fitness effects of Copy Number Variation in the Roma
We provide the first whole genome Copy Number Variant (CNV) study addressing Roma, along with reference populations from South Asia, the Middle East...
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Computational textural map** harmonises sampling variation and reveals multidimensional histopathological fingerprints
BackgroundTechnical factors can bias H&E digital slides potentially compromising computational histopathology studies. Here, we hypothesised that...
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Decoding the basis of histological variation in human cancer
Molecular abnormalities that shape human neoplasms dissociate their phenotypic landscape from that of the healthy counterpart. Through the lens of a...
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Sex-dependent variation in cartilage adaptation: from degeneration to regeneration
Despite acknowledgement in the scientific community of sex-based differences in cartilage biology, the implications for study design remain unclear,...
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Contrasts in riverscape patterns of intraspecific genetic variation in a diverse Neotropical fish community of high conservation value
Spatial patterns of genetic variation compared across species provide information about the predictability of genetic diversity in natural...
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HPV18 L1 and long control region sequences variation and E6/E7 differential expression in nasopharyngeal and cervical cancers: a comparative study
BackgroundThe role of high-risk human papillomaviruses (hr-HPVs) in cervical cancer (CC) pathogenesis has long been established. Knowledge about the...
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Ecotype variation in the endemic tree Callicarpa subpubescens on small oceanic islands: genetic, phenotypic, and environmental insights
Callicarpa subpubescens , endemic to the Ogasawara Islands, is suggested to have multiple ecotypes in the Hahajima Islands, specifically in the...
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Inter-epitope spacer variation within polytopic L2-based human papillomavirus antigens affects immunogenicity
The human papillomavirus minor capsid protein L2 is being extensively explored in pre-clinical studies as an attractive vaccine antigen capable of...
