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Interleukin (IL)-7 Signaling in the Tumor Microenvironment
Interleukin (IL)-7 plays an important immunoregulatory role in different types of cells. Therefore, it attracts researcher’s attention, but despite...
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Interleukin-7 regulates CD127 expression and promotes CD8+ T cell activity in patients with primary cutaneous melanoma
BackgroundInterleukin (IL)-7 signaling through CD127 is impaired in lymphocytes in cancers and chronic infections, resulting in CD8 + T cell...
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The Role of Interleukin (IL)-6/IL-6 Receptor Axis in Cancer
As a pleiotropic cytokine, interleukin (IL)-6 plays a key role in mediating the host’s immune defense. Multiple cell types are involved in IL-6...
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A novel cocktail therapy based on quintuplet combination of oncolytic herpes simplex virus-2 vectors armed with interleukin-12, interleukin-15, GM-CSF, PD1v, and IL-7 × CCL19 results in enhanced antitumor efficacy
BackgroundSelectively replicating herpes simplex virus-2 (HSV-2) vector is a promising treatment for cancer therapy. The insertion of multiple...
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α7 Nicotinic acetylcholine receptor: a key receptor in the cholinergic anti-inflammatory pathway exerting an antidepressant effect
Depression is a common mental illness, which is related to monoamine neurotransmitters and the dysfunction of the cholinergic, immune, glutamatergic,...
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Association of TRAIL receptor with phosphatase SHP-1 enables repressing T cell receptor signaling and T cell activation through inactivating Lck
BackgroundT cell receptor (TCR) signaling and T cell activation are tightly regulated by gatekeepers to maintain immune tolerance and avoid...
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Targeting IL-6 or IL-6 Receptor in Rheumatoid Arthritis: What Have We Learned?
The use of different pathways in the treatment of rheumatoid arthritis has led to a significant decrease in the number of treatment-resistant...
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Germline HAVCR2/TIM-3 Checkpoint Inhibitor Receptor Deficiency in Recurrent Autoinflammatory Myocarditis
Myocarditis can be caused by viral infection, drug reaction or general inflammatory condition. To provide understanding on inflammatory myocarditis,...
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Aryl hydrocarbon receptor regulates IL-22 receptor expression on thymic epithelial cell and accelerates thymus regeneration
Improving regeneration of damaged thymus is important for reconstituting T-cell immunity. Interleukin-22 (IL-22) was proved to improve thymus...
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P2X7 receptor is essential for ST36-attenuated cardiac fibrosis upon beta-adrenergic insult
P2X7 receptor (P2X7R) plays an important role in modulating inflammation and fibrosis, but information is limited whether Zusanli (ST36) can inhibit...
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Rutin ameliorates inflammatory pain by inhibiting P2X7 receptor in mast cells
Rutin is a natural anti-inflammatory ingredient widely found in medicinal plants. Studies have shown that rutin inhibits mast cell degranulation and...
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Generation of Redirected Engineered Human Chimeric Antigen Receptor (CAR) T Cells
Chimeric antigen receptor (CAR)Chimeric antigen receptor (CAR) T cellT-cell therapy that involves genetic engineeringGenetic engineering a patient’s...
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The Role of the Soluble Interleukin-6 Receptor in the Progression of Nonalcoholic Fatty Liver Disease
The blood level of soluble IL-6 receptor was measured in patients with different clinical and morphological forms of nonalcoholic fatty liver disease...
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Retinoic Acid Receptor-Related Orphan Receptors (RORs) in Eye Development and Disease
The retinoic acid receptor-related orphan receptors (RORs) are ligand-mediated transcription factors with important biological roles in regulating...
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Modelling the Response to Interleukin-7 Therapy in HIV-Infected Patients
IL-7 is a cytokine produced by stromal cells in the thymus and bone marrow, epithelial cells and dendritic cells. This cytokine plays a key role in...
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Interleukin-1 Receptor Antagonist as Therapy for Traumatic Brain Injury
Traumatic brain injury is a common type of acquired brain injury of varying severity carrying potentially deleterious consequences for the afflicted...
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Capsaicin, The Vanilloid Receptor TRPV1 Agonist in Neuroprotection: Mechanisms Involved and Significance
Hot peppers, also called chilli, chilli pepper, or paprika of the plant genus Capsicum (family Solanaceae ), are one of the most used vegetables and...
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Toll-like receptor 4 (TLR4): new insight immune and aging
TLR4, a transmembrane receptor, plays a central role in the innate immune response. TLR4 not only engages with exogenous ligands at the cellular...
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Cytochrome P450 activity in rheumatoid arthritis patients during continuous IL-6 receptor antagonist therapy
Abstract BackgroundInflammation suppresses cytochrome P450 (CYP) enzyme activity, and single-dose interleukin 6 receptor antagonists (anti-IL-6R)...
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The Strategy of Targeting Peroxisome Proliferator-Activated Receptor (PPAR) in the Treatment of Neuropsychiatric Disorders
Peroxisome proliferator-activated receptors (PPARs) are nonsteroid nuclear receptors and transcription factors that regulate several...