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Linking interindividual variability in brain structure to behaviour
What are the brain structural correlates of interindividual differences in behaviour? More than a decade ago, advances in structural MRI opened...
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Interindividual variability in transgene mRNA and protein production following adeno-associated virus gene therapy for hemophilia A
Factor VIII gene transfer with a single intravenous infusion of valoctocogene roxaparvovec (AAV5-hFVIII-SQ) has demonstrated clinical benefits...
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Sources of Interindividual Variability
The efficacy, safety, and tolerability of drugs are dependent on numerous factors that influence their disposition. A dose that is efficacious and...
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The method for assessment of local permutations in the glomerular patterns of the rat olfactory bulb by aligning interindividual odor maps
The comparison of odor functional maps in rodents demonstrates a high degree of inter-individual variability in glomerular activity patterns. There...
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Individual variability in brain representations of pain
Characterizing cerebral contributions to individual variability in pain processing is crucial for personalized pain medicine, but has yet to be done....
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Topographical functional correlates of interindividual differences in executive functions in young healthy twins
Executive functions (EF) are a set of higher-order cognitive abilities that enable goal-directed behavior by controlling lower-level operations. In...
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Map** interindividual dynamics of innate immune response at single-cell resolution
Common genetic variants across individuals modulate the cellular response to pathogens and are implicated in diverse immune pathologies, yet how they...
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Inter-individual, hemispheric and sex variability of brain activations during numerosity processing
Numerosity perception is a fundamental and innate cognitive function shared by both humans and many animal species. Previous research has primarily...
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ACE2 gene variants may underlie interindividual variability and susceptibility to COVID-19 in the Italian population
In December 2019, an initial cluster of interstitial bilateral pneumonia emerged in Wuhan, China. A human-to-human transmission was assumed and a...
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Variability of temperature measurements recorded by a wearable device by biological sex
BackgroundFemales have been historically excluded from biomedical research due in part to the documented presumption that results with male subjects...
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Interloci CNV Interactions in Variability of the Phenotypes of Neurodevelopmental Disorders
AbstractMost copy number variations (CNV) of pathogenetic significance are associated with neurodevelopmental phenotypes and characterized by...
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Variability in Human In Vitro Enzyme Kinetics
There are many factors which are known to cause variability in human in vitro enzyme kinetic data. Factors such as the source of enzyme and how it...
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Microdialysis of Voriconazole and its N-Oxide Metabolite: Amalgamating Knowledge of Distribution and Metabolism Processes in Humans
PurposeVoriconazole is an essential antifungal drug whose complex pharmacokinetics with high interindividual variability impedes effective and safe...
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GWAS and GWAIS for Identifying Connections Between Genetics, Nutrition, and Health: The Example of Omega-3 and Plasma Triglycerides
Given the large interindividual variability observed in the plasma lipid responsiveness to nutritional intake, researchers are interested in...
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GWAS and GWAIS for Identifying Connections Between Genetics, Nutrition, and Health: The Example of Omega-3 and Plasma Triglycerides
Given the large interindividual variability observed in the plasma lipid responsiveness to nutritional intake, researchers are interested in...
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Population pharmacokinetic modeling of levodropropizine: extended application to comparative analysis between commercial formulations and exploration of pharmacokinetic effects of diet
Levodropropizine, a nonopioid antitussive agent, is being increasingly used in clinical practice with the development of several formulations for...
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Being precise with anticoagulation to reduce adverse drug reactions: are we there yet?
Anticoagulants are potent therapeutics widely used in medical and surgical settings, and the amount spent on anticoagulation is rising. Although...
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Circadian phase advances in children during cam** life according to the natural light-dark cycle
BackgroundIt is known that the circadian rhythm phase in adults can be advanced in a natural light-dark cycle without electrical lighting. However,...
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Dependence of Bioavailability on Mean Absorption Time: What Does It Tell Us?
The extent and rate of bioavailability are fundamental measures to characterize the pharmacokinetics of drugs after oral administration. Together...
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Acetylcholinesterase inhibition in electric eel and human donor blood: an in vitro approach to investigate interspecies differences and human variability in toxicodynamics
In chemical risk assessment, default uncertainty factors are used to account for interspecies and interindividual differences, and differences in...
