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A bispecific Clec9A-PD-L1 targeted type I interferon profoundly reshapes the tumor microenvironment towards an antitumor state
Despite major improvements in immunotherapeutic strategies, the immunosuppressive tumor microenvironment remains a major obstacle for the induction...
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RAS signaling and immune cells: a sinister crosstalk in the tumor microenvironment
The rat sarcoma virus (RAS) gene is the most commonly mutated oncogene in cancer, with about 19% of cancer patients carrying RAS mutations. Studies...
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Introduction to Tumor Microenvironment
The knowledge of tumor microenvironment (TME) has grown exponentially in recent decades. TME is a complex milieu with an essential role in tumor...
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Breast Tumor Microenvironment and CDKs
Breast malignancy is one of the most frequently diagnosed carcinoma in women globally, and it is also the common reason for tumor-associated fatality...
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The linkage of NF-κB signaling pathway-associated long non-coding RNAs with tumor microenvironment and prognosis in cervical cancer
BackgroundNF-κB signaling pathway participate closely in regulating inflammation and immune response in many cancers. Long non-coding RNAs (lncRNAs)...
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Basic Insights into Tumor Microenvironment in Prostate Cancer
Prostate cancer, a prominent malignancy impacting men worldwide, is characterized by a dynamic and intricate interplay between cancer cells and their...
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Unleashing the potential of combining FGFR inhibitor and immune checkpoint blockade for FGF/FGFR signaling in tumor microenvironment
BackgroundFibroblast growth factors (FGFs) and their receptors (FGFRs) play a crucial role in cell fate and angiogenesis, with dysregulation of the...
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Hypoxic Tumor Microenvironment: Driver for Cancer Progression
Hypoxia or low oxygen concentration is one of the major physiological parameters within tumor microenvironment (TME). It has a profound effect in...
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Glycolysis-related biomarker TCIRG1 participates in regulation of renal cell carcinoma progression and tumor immune microenvironment by affecting aerobic glycolysis and AKT/mTOR signaling pathway
BackgroundRenal cell carcinoma (RCC) is a hypermetabolic disease. Abnormal up-regulation of glycolytic signaling promotes tumor growth, and...
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Role of Immune Cells in the Tumor Microenvironment
The tumor microenvironment (TME) encloses a repertoire of immune cells besides cancer cells. The role of immune cells in the TME plays an essential...
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Targeting metabolism to enhance immunotherapy within tumor microenvironment
Cancer metabolic reprogramming has been considered an emerging hallmark in tumorigenesis and the antitumor immune response. Like cancer cells, immune...
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Metabolic regulation of tumor-associated macrophage heterogeneity: insights into the tumor microenvironment and immunotherapeutic opportunities
Tumor-associated macrophages (TAMs) are a heterogeneous population that play diverse functions in tumors. Their identity is determined not only by...
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Cancer cell states recur across tumor types and form specific interactions with the tumor microenvironment
Transcriptional heterogeneity among malignant cells of a tumor has been studied in individual cancer types and shown to be organized into cancer cell...
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CXCL8 Signaling in the Tumor Microenvironment
The tumor microenvironment represents a dynamic and complex cellular network involving intricate communications between the tumor and highly...
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Role of C-Type Lectins in the Tumor Microenvironment
C-type lectin receptors (CLRs) represent a broad and diversified family of pattern recognition receptors (PRRs) that are mainly expressed on the...
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Angiogenesis and the Tumor Microenvironment
Tumorigenesis is a complex and multistep process involving genetic and epigenetic changes within the tumor cell, as well as supportive conditions...
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Spatial Transcriptomic Approaches for Understanding the Tumor Microenvironment (TME)
The tumor microenvironment (TME) is a heterogeneous milieu of cellular and molecular factors that play a crucial role in tumor evolution and disease...
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Tumor immune microenvironment-based therapies in pancreatic ductal adenocarcinoma: time to update the concept
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal solid tumors. The tumor immune microenvironment (TIME) formed by interactions among...
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CXCL13 Signaling in the Tumor Microenvironment
Chemokines have emerged as important players in tumorigenic process. An extensive body of literature generated over the last two or three decades...
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Normalization of the tumor microenvironment by harnessing vascular and immune modulation to achieve enhanced cancer therapy
Solid tumors are complex entities that actively shape their microenvironment to create a supportive environment for their own growth. Angiogenesis...
