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A Case of Autosomal Recessive Interferon Alpha/Beta Receptor Alpha Chain (IFNAR1) Deficiency with Severe COVID-19
BackgroundInterferons (IFNs) play a crucial role in antiviral immunity. Genetic defects in interferon receptors, IFNs, and auto-antibodies against...
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Mechanisms of host type I interferon response modulation by the nucleocapsid proteins of alpha- and betacoronaviruses
Coronaviruses can have a devastating impact on the health of humans and animals. Porcine epidemic diarrhea virus (PEDV) causes extremely high...
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Interferon-alpha or -beta facilitates SARS-CoV-2 pulmonary vascular infection by inducing ACE2
Severe viral pneumonia caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is characterized by a hyperinflammatory state...
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Type I Interferon: Monkeypox/Mpox Viruses Achilles Heel?
Poxviruses are notorious for having acquired/evolved numerous genes to counteract host innate immunity. Chordopoxviruses have acquired/evolved at...
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Antiviral drugs arbidol and interferon alpha-1b contribute to reducing the severity of COVID-19 patients: a retrospective cohort study
ObjectivesThe aim of this study was to evaluate the role of antiviral drugs in reducing the risk of develo** severe illness in patients with...
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Tumor Necrosis Factor-Alpha (TNF-Alpha) as a Biomarker in Trauma and Critical Care
Tumor necrosis factor-alpha (TNF-α) is mainly synthesized from monocytes and macrophages. It is a kind of glycoprotein that also contributes to the...
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Interferon-Alpha Receptor-1 (IFNAR1) Polymorphisms
Plasmodium falciparum infection is one of the major health problems worldwide. The role of host genetic factors is evidenced in malaria. Dysregulated...
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Differential Expression of Interferon-Alpha Protein Provides Clues to Tissue Specificity Across Type I Interferonopathies
Whilst upregulation of type I interferon (IFN) signaling is common across the type I interferonopathies (T1Is), central nervous system (CNS)...
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Interleukin-17A pretreatment attenuates the anti-hepatitis B virus efficacy of interferon-alpha by reducing activation of the interferon-stimulated gene factor 3 transcriptional complex in hepatitis B virus-expressing HepG2 cells
BackgroundSome cytokine signaling pathways can interact with interferon (IFN)-α pathway and thus regulate cell responses to IFN-α. Levels of the...
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RNA sequencing analysis reveals the competing endogenous RNAs interplay in resected hepatocellular carcinoma patients who received interferon-alpha therapy
BackgroundInterferon-alpha (IFN-α) is a general therapeutic regimen to be utilized in hepatocellular carcinoma (HCC). However, regulatory mechanisms...
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Staphylococcal protein A modulates inflammation by inducing interferon signaling in human nasal epithelial cells
Objective and designStaphylococcus aureus ( S. aureus ) is one of the leading causes of human respiratory tract infections. The function of...
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GBP2 acts as a member of the interferon signalling pathway in lupus nephritis
Lupus nephritis (LN) is a common and serious clinical manifestation of systemic lupus erythematosus. However, the pathogenesis of LN is not fully...
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Microglia Signaling Pathway Reporters Unveiled Manganese Activation of the Interferon/STAT1 Pathway and Its Mitigation by Flavonoids
Neuroinflammatory responses to neurotoxic manganese (Mn) in CNS have been associated with the Mn-induced Parkinson-like syndromes. However, the...
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Prevalence of Neutralizing Autoantibodies Against Type I Interferon in a Multicenter Cohort of Severe or Critical COVID-19 Cases in Shanghai
ObjectiveWe sought to explore the prevalence of type I interferon-neutralizing antibodies in a Chinese cohort and its clinical implications during...
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Interferon-γ and its response are determinants of antibody-mediated rejection and clinical outcomes in patients after renal transplantation
Interferon-γ (IFN-γ) is an important cytokine in tissue homeostasis and immune response, while studies about it in antibody-mediated rejection (ABMR)...
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Tumor Necrosis Factor-Alpha (TNF-Alpha) as a Biomarker in Trauma and Critical Care
Tumor necrosis factor-alpha (TNF-α) is mainly synthesized from monocytes and macrophages. It is a kind of glycoprotein that also contributes to the...
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Sorafenib inhibits interferon production by plasmacytoid dendritic cells in hepatocellular carcinoma
BackgroundSorafenib is a multi-kinase inhibitor that shows antitumor activity in advanced hepatocellular carcinoma. Sorafenib exerts a regulatory...
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Zidovudine and Interferon Alfa based regimens for the treatment of adult T-cell leukemia/lymphoma (ATLL): a systematic review and meta-analysis
BackgroundATLL (Adult T-Cell Leukemia/Lymphoma) is an aggressive hematological malignancy. This T-cell non-Hodgkin lymphoma, caused by the human...
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Influenza a virus regulates interferon signaling and its associated genes; MxA and STAT3 by cellular miR-141 to ensure viral replication
The antiviral response against influenza A virus (IAV) infection includes the induction of the interferon (IFN) signaling pathway, including...
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Interferon-induced transmembrane protein 3 in hepatocellular carcinoma patients
ObjectiveThe study aimed to investigate the over expression of IFITM3 in hepatocellular carcinoma Egyptian patients.
BackgroundHepatocellular...
