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A proton birdcage coil integrated with interchangeable single loops for multi-nuclear MRI/MRS
Energy metabolism is fundamental for life. It encompasses the utilization of carbohydrates, lipids, and proteins for internal processes, while...
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A longitudinal study on the interchangeable use of whole-body and local exercise thresholds in cycling
PurposeThis study longitudinally examined the interchangeable use of critical power (CP), the maximal lactate steady state (MLSS) and the respiratory...
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Interchangeability for Biologics is a Legal Distinction in the USA, Not a Clinical One
Biologics are increasingly vital medicines that significantly reduce morbidity as well as mortality, yet access continues to be an issue even in...
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The concurrent validity of the Lund University Checklist for Incipient Exhaustion and the Karolinska Exhaustion Disorder Scale: a replication study
ObjectiveAs part of our research on Swedish school principals, we examined the concurrent validity between the Karolinska Exhaustion Disorder Scale...
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Prediction of SBRT response in liver cancer by combining original and delta cone-beam CT radiomics: a pilot study
This study aims to explore the feasibility of utilizing a combination of original and delta cone-beam CT (CBCT) radiomics for predicting treatment...
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Dissolution profile evaluation of selected brands of amoxicillin-clavulanate potassium 625 mg tablets retailed in Hawassa town, Sidama Regional State, Ethiopia
Poor quality amoxicillin-clavulanate potassium tablets have been recently discovered in generic drugs related to Augmentin-like medicines containing...
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Assessing the Interchangeability of AVT02 and Humira® in Participants with Moderate‑to‑Severe Chronic Plaque Psoriasis: Pharmacokinetics, Efficacy, Safety, and Immunogenicity Results from a Multicenter, Double-Blind, Randomized, Parallel-Group Study
BackgroundThe US Food and Drug Administration (FDA) interchangeability guidelines state that the primary endpoint in a switching study should assess...
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Switch from a ritonavir to a cobicistat containing antiretroviral regimen and impact on tacrolimus levels in a kidney transplant recipient
BackgroundSolid-organ transplantation due to end-stage organ disease is increasingly performed in people living with HIV. Despite improved transplant...
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Head-to-head comparison of plasma and PET imaging ATN markers in subjects with cognitive complaints
BackgroundGaining more information about the reciprocal associations between different biomarkers within the ATN (Amyloid/Tau/Neurodegeneration)...
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Performance of the Roche Elecsys® IGRA SARS-CoV-2 test for the detection and quantification of virus-reactive T cells in COVID-19-vaccinated immunosuppressed patients and healthy subjects
PurposeComparing the performance of commercially available SARS-CoV-2 T-cell immunoassay responses may provide useful information for future...
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Tinzaparin—a review of its molecular profile, pharmacology, special properties, and clinical uses
PurposeLow molecular weight heparins (LMWHs) are a group of heterogenous moieties, long used in the prevention and treatment of thrombosis. They...
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Diagnostic value of serum versus plasma phospho-tau for Alzheimer’s disease
BackgroundBlood phosphorylated tau (p-tau) forms are promising Alzheimer’s disease (AD) biomarkers, but validation in matrices other than...
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A low-cost phantom design for evaluating spine SABR calculations in the presence of prosthetic vertebral stabilization
Dose-perturbation characteristics are important to consider during the calculation of radiation therapy protocols for patients who are going to...
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Use of Biosimilars: A Systematic Review of Published Position Statements and Recommendations from Health Organisations and Societies
BackgroundHesitation about using biosimilars still exists among healthcare professionals (HCPs), despite extensive experience with their use....
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Establishment of a Modular Hemodynamic Simulator for Accurate In Vitro Simulation of Physiological and Pathological Pressure Waveforms in Native and Bioartificial Blood Vessels
PurposeIn vitro stimulation of native and bioartificial vessels in perfusable systems simulating natural mechanical environments of the human...
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Overview of Biosimilars
Biotechnological drugs are increasingly crucial in modern medicine, which anticipated to occupy half the pharmaceutical market soon. Patent...
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Understanding US Physician and Pharmacist Attitudes Toward Biosimilar Products: A Qualitative Study
BackgroundBiosimilars account for 30–40% of biologic medications dispensed in the United States (US), yet healthcare providers in relevant medical...
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Regulatory Considerations of Biosimilars in Cancer
In the fast-evolving field of cancer treatment, the introduction of biosimilars has brought about significant changes in the available therapeutic...
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Viscoelastic Hemostatic Tests and Fibrinogen Concentrations in Trauma
Thrombelastography (TEG) and rotational thromboelastometry (ROTEM) are used to diagnose trauma-induced coagulopathy, fibrinogen deficiency, and guide...
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A Comprehensive Analysis of Biopharmaceutical Products Listed in the FDA’s Purple Book
Although biopharmaceuticals constitute around 10% of the drug landscape, eight of the ten top-selling products were biopharmaceuticals in 2023. This...
