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Insulin Resistance and Diabetes
In this chapter, we will describe the molecular principles of glucose homeostasis and insulin signaling as well as their dysregulation leading to...
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Markers of Liver Function and Insulin Resistance
Diagnostic features for metabolic syndrome include cardiovascular risk factors, like increased abdominal circumference, triglycerides, and blood...
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Insulin Resistance and Cancer
Insulin is a peptide hormone that mediates both metabolic and mitogenic effects, and impaired insulin signaling leads to insulin resistance with...
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PKCα Isoform Inhibits Insulin Signaling and Aggravates Neuronal Insulin Resistance
Overexpression of PKCα has been linked to inhibit insulin signaling disrupting IRS-1 and Akt phosphorylations in skeletal muscle. PKCα inhibits IRS-1...
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Insulin
Insulin was discovered by Banting and Best in 1921. Soon afterwards, manufacturing processes were developed to extract the insulin from porcine and...
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Placental IGFBP1 levels during early pregnancy and the risk of insulin resistance and gestational diabetes
Reduced insulin sensitivity (insulin resistance) is a hallmark of normal physiology in late pregnancy and also underlies gestational diabetes...
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Markers of Liver Function and Insulin Resistance
Diagnostic features for metabolic syndrome include cardiovascular risk factors, like increased abdominal circumference, triglycerides, and blood...
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Blocking Fas signaling in adipose tissue ameliorates obesity-associated inflammation, insulin resistance, and hepatosteatosis
PurposeAdipose tissue inflammation is a crucial early stage of obesity-related metabolic dysfunction and insulin resistance. Adipocytes, and...
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Glycemic status, insulin resistance, and mortality from lung cancer among individuals with and without diabetes
BackgroundThe effects of glycemic status and insulin resistance on lung cancer remain unclear. We investigated the associations between both glycemic...
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Altered insulin secretion dynamics relate to oxidative stress and inflammasome activation in children with obesity and insulin resistance
BackgroundInsulin resistance (IR) is considered the main driver of obesity related metabolic complications, and is related to oxidative stress and...
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Brain insulin resistance and the therapeutic value of insulin and insulin-sensitizing drugs in Alzheimer’s disease neuropathology
The incidence of Alzheimer’s disease (AD) is significantly higher in people with diabetes. Insulin and insulin receptor (IR) signaling intermediates...
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Effects of levothyroxine replacement therapy on insulin resistance in patients with untreated primary hypothyroidism
ObjectivesThis study investigated the effects of levothyroxine replacement therapy on insulin resistance, lipid profile, and thyroid function in...
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Association between insulin resistance and multiple sclerosis: a systematic review and meta-analysis
There is increasing evidence of metabolic perturbations in multiple sclerosis (MS) patients, and insulin is an important parameter that has...
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Complex rearrangement in TBC1D4 in an individual with diabetes due to severe insulin resistance syndrome
Severe insulin resistance syndromes result from primary insulin signaling defects, adipose tissue abnormalities or other complex syndromes. Mutations...
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Obesity blunts insulin sensitivity improvements and attenuates strength gains following resistance training in nondiabetic men
PurposeImpaired insulin sensitivity is central in the etiology of type 2 diabetes in people with obesity. The effectiveness of resistance training...
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NF-κB-Inducing Kinase Provokes Insulin Resistance in Skeletal Muscle of Obese Mice
Skeletal muscle is crucial for preserving glucose homeostasis. Insulin resistance and abnormalities in glucose metabolism result from a range of...
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From Determining Brain Insulin Resistance in a Sporadic Alzheimer’s Disease Model to Exploring the Region-Dependent Effect of Intranasal Insulin
Impaired response to insulin has been linked to many neurodegenerative disorders like Alzheimer’s disease (AD). Animal model of sporadic AD has been...
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Candesartan, an angiotensin-II receptor blocker, ameliorates insulin resistance and hepatosteatosis by reducing intracellular calcium overload and lipid accumulation
Insulin resistance is a major contributor to the pathogenesis of several human diseases, including type 2 diabetes, hypertension, and hyperlipidemia....
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Alogliptin: a DPP-4 inhibitor modulating adipose tissue insulin resistance and atherogenic lipid
AimsThe purpose of this study is to investigate the regulation of adipose tissue insulin resistance with DPP-4 inhibitors in treatment-naive subjects...
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Mitochondria targeted esculetin administration improves insulin resistance and hyperglycemia-induced atherosclerosis in db/db mice
AbstractThe development and progression of hyperglycemia (HG) and HG-associated atherosclerosis are exacerbated by mitochondrial dysfunction due to...
