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Pharmacology of Mammalian Na+-Dependent Transporters of Inorganic Phosphate
Inorganic phosphate (Pi) is an essential component of many biologically important molecules such as DNA, RNA, ATP, phospholipids, or apatite. It is...
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Phosphate Burden and Inflammation
Phosphate is an essential macromineral often introduced to the body through dietary intake. The mechanisms for maintaining phosphate levels are...
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Microfluidic Production of Inorganic Nanoparticles
Inorganic nanoparticles (NPs) have considerable potential for biomedical applications, such as drug delivery, cancer imaging, and cell tracking....
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Phosphate Is a Cardiovascular Toxin
Phosphate is essential for proper cell function by providing the fundamentals for DNADNA, cellular structure, signaling and energy production. The...
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Vitamin D and Phosphate Interactions in Health and Disease
Vitamin D plays an essential role in calcium and inorganic phosphate (Pi) homeostasis, maintaining their optimal levels to assure adequate bone...
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Phosphate and Endothelial Function: How Sensing of Elevated Inorganic Phosphate Concentration Generates Signals in Endothelial Cells
Present in all cells, inorganic phosphateInorganic phosphates (Pi) is involved in regulating a wide range of fundamental cellular processes including...
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Phosphate and Cellular Senescence
Cellular senescence is one type of permeant arrest of cell growth and one of increasingly recognized contributor to aging and age-associated disease....
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Extracellular Phosphate, Inflammation and Cytotoxicity
Phosphorus is an essential nutrient that plays a crucial role in various biological processes, including cell membrane integrity, synthesis of...
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Phosphate Metabolism: From Physiology to Toxicity
Systemic phosphate homeostasis is tightly controlled by the delicate cross-organ talk among intestine, kidney, bone, and parathyroid glands. The...
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Common Dietary Sources of Natural and Artificial Phosphate in Food
The Recommended Dietary Allowance (RDA) for phosphate in the U.S. is around 700 mg/day for adults. The majority of healthy adults consume almost...
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Phosphate Toxicity and Epithelial to Mesenchymal Transition
The underlying role of inadequate or excess intake of phosphate is evident in disease states, including metabolic, skeletal, cardiac, kidney and...
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Phosphate intake, hyperphosphatemia, and kidney function
Phosphate is essential in living organisms and its blood levels are regulated by a complex network involving the kidneys, intestine, parathyroid...
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Strategy for Cytoplasmic Delivery Using Inorganic Particles
Endosome escape is a key process for intracellular uptake of intact biomolecules and therapeutics, such as nucleic acids. Lysosome escape is a more...
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XPR1: a regulator of cellular phosphate homeostasis rather than a Pi exporter
Phosphate (Pi) is an essential nutrient, and its plasma levels are under tight hormonal control. Uphill transport of Pi into cells is mediated by the...
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Doxycycline-Loaded Calcium Phosphate Nanoparticles with a Pectin Coat Can Ameliorate Lipopolysaccharide-Induced Neuroinflammation Via Enhancing AMPK
Neuroinflammation occurs in response to different injurious triggers to limit their hazardous effects. However, failure to stop this process can end...
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Recent progress and drug delivery applications of surface-functionalized inorganic nanoparticles in cancer therapy
BackgroundCancer remains a major global health burden and existing therapeutic approaches face substantial challenges such as drug resistance, poor...
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Characterizing the toxicological responses to inorganic arsenicals and their metabolites in immortalized human bladder epithelial cells
Arsenic is highly toxic to the human bladder. In the present study, we established a human bladder epithelial cell line that closely mimics normal...
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An Optical Sensing Platform for Beta-Glucosidase Activity Using Protein-Inorganic Hybrid Nanoflowers
In this work, a convenient and dual-signal readout optical sensing platform for the sensitively and selectively determination of beta-glucosidase...
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Fibroblast Growth Factor 23 as Regulator of Vitamin D Metabolism
Fibroblast growth factor 23 (FGF23FGF23) is a hormone produced by osteocytesOsteocytes in bone that acts on the kidneys to regulate phosphate and...
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Elevation of phosphate levels impairs skeletal myoblast differentiation
Hyperphosphatemic conditions such as chronic kidney disease are associated with severe muscle wasting and impaired life quality. While regeneration...
