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The Impact of US Medical Product Regulatory Complexity on Innovation: Preliminary Evidence of Interdependence, Early Acceleration, and Subsequent Inversion
PurposeIs the complexity of medical product (medicines and medical devices) regulation impacting innovation in the US? If so, how?
Methods ...
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Vaccine Innovation Meta-Model for Pandemic Contexts
PurposeOver the past decade, successive outbreaks and epidemics of infectious diseases have challenged the emergency preparedness and response...
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Exploring the future adult vaccine landscape—crowded schedules and new dynamics
Amidst the backdrop of the COVID-19 pandemic, vaccine innovation has garnered significant attention, but this field was already on the cusp of a...
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A computational model of motion sickness dynamics during passive self-motion in the dark
Predicting the time course of motion sickness symptoms enables the evaluation of provocative stimuli and the development of countermeasures for...
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RETRACTED ARTICLE: A computational model of motion sickness dynamics during passive self-motion in the dark
Predicting the time course of motion sickness symptoms enables the evaluation of provocative stimuli and the development of countermeasures for...
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Biomedical Technology Innovation Education and Its Effect on Graduate Student Careers Over 17 Years
In the 1990s, interest in biomedical technologies blossomed among students across disciplines. In parallel, there was a push in academia to develop...
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Early Handling Exerts Anxiolytic Effects and Alters Brain Mitochondrial Dynamics in Adult High Anxiety Mice
Early handling (EH), the brief separation of pups from their mother during early life, has been shown to exert beneficial effects. However, the...
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Molecular dynamics exploration of Lupenone: therapeutic implications for glioblastoma multiforme and alzheimer's amyloid beta pathogenesis
Neuro-oncological and neurodegenerative disorders, represented paradigmatically by glioblastoma and Alzheimer's disease, respectively, persist as...
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Current challenges in metastasis research and future innovation for clinical translation
While immense strides have been made in understanding tumor biology and in develo** effective treatments that have substantially improved the...
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A deep learning framework for inference of single-trial neural population dynamics from calcium imaging with subframe temporal resolution
In many areas of the brain, neural populations act as a coordinated network whose state is tied to behavior on a millisecond timescale. Two-photon...
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Distinct dynamics of mRNA LNPs in mice and nonhuman primates revealed by in vivo imaging
The characterization of vaccine distribution to relevant tissues after in vivo administration is critical to understanding their mechanisms of...
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Prediction of Thrombosis After Coil Embolization of Unruptured Cerebral Aneurysm by Computational Fluid Dynamics Using Porous Media Modeling
PurposePreoperative simulations tailored to the therapeutic device are desirable to predict treatment efficacy. We investigated the hemodynamics...
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Predictive, preventive and personalised approach as a conceptual and technological innovation in primary and secondary care of inflammatory bowel disease benefiting affected individuals and populations
Inflammatory bowel disease (IBD) is a global health burden which carries lifelong morbidity affecting all age groups in populations with the...
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A Multi-level Perspective to Biosimilars Development: Pathways Towards Incremental Innovation in the Health Bioeconomy
Biosimilar development is one of the extraordinary changes swee** through the pharmaceutical industry, providing an opportunity for incremental...
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Neurodesign: The Biology, Psychology, and Engineering of Creative Thinking and Innovation
Creative thinkingThinking, creative pervades human lifeLife. Almost every single thing with which humans surround themselves—technologyTechnology,...
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Mini-encyclopedia of mitochondria-relevant nutraceuticals protecting health in primary and secondary care—clinically relevant 3PM innovation
Despite their subordination in humans, to a great extent, mitochondria maintain their independent status but tightly cooperate with the “host” on...
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Dynamics of ram** bursts in a respiratory neuron model
Intensive computational and theoretical work has led to the development of multiple mathematical models for bursting in respiratory neurons in the...
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Neonatal and carrier screening for rare diseases: how innovation challenges screening criteria worldwide
Screening for rare diseases first began more than 50 years ago with neonatal bloodspot screening (NBS) for phenylketonuria, and carrier screening for...
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Nutrient dynamics in coral symbiosis depend on both the relative and absolute abundance of Symbiodiniaceae species
BackgroundSymbionts provide a variety of reproductive, nutritional, and defensive resources to their hosts, but those resources can vary depending on...
