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Muscle stem cells and fibro-adipogenic progenitors in female pelvic floor muscle regeneration following birth injury
Pelvic floor muscle (PFM) injury during childbirth is a key risk factor for pelvic floor disorders that affect millions of women worldwide. Muscle...
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Myogenic tissue nanotransfection improves muscle torque recovery following volumetric muscle loss
This work rests on our non-viral tissue nanotransfection (TNT) platform to deliver MyoD (TNT MyoD ) to injured tissue in vivo. TNT MyoD was performed on...
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Kinin receptors regulate skeletal muscle regeneration: differential effects for B1 and B2 receptors
Objective and designAfter traumatic skeletal muscle injury, muscle healing is often incomplete and produces extensive fibrosis. Bradykinin (BK)...
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Brachial Plexus Root Avulsion Injury-Induced Endothelin-Converting Enzyme-Like 1 Overexpression Is Associated with Injured Motor Neurons Survival
Brachial plexus root avulsion (BPRA) injury arises from challenging delivery during childbirth, sports-related incidents, or car accidents, leading...
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From inflammation to bone formation: the intricate role of neutrophils in skeletal muscle injury and traumatic heterotopic ossification
Neutrophils are emerging as an important player in skeletal muscle injury and repair. Neutrophils accumulate in injured tissue, thus releasing...
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Icing after skeletal muscle injury decreases M1 macrophage accumulation and TNF-α expression during the early phase of muscle regeneration in rats
Following skeletal muscle injury, both myogenic and immune cells interact closely during the regenerative process. Although icing is still a common...
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A discrete ‘early-responder’ stromal-cell subtype orchestrates immunocyte recruitment to injured tissue
Following acute injury, stromal cells promote tissue regeneration by a diversity of mechanisms. Time-resolved single-cell RNA sequencing of muscle...
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Return of the Tbx5; lineage-tracing reveals ventricular cardiomyocyte-like precursors in the injured adult mammalian heart
The single curative measure for heart failure patients is a heart transplantation, which is limited due to a shortage of donors, the need for...
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Circulating TGF-β1 Levels: Linking Muscle and Trauma
Transforming growth factor-beta 1 (TGF-β1) is a multifunctional growth factor that plays a key role in a variety of human tissues. Three TGF-β1...
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Mechanisms of cooperative cell-cell interactions in skeletal muscle regeneration
Skeletal muscles have an extraordinary capacity to regenerate themselves when injured. Skeletal muscle stem cells, called satellite cells, play a...
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Autophagy in Muscle Stem Cells
Muscle stem cellsMuscle stem cell, also known as satellite cellsSatellite cell, are responsible for the regenerative capacity of adult muscle tissue...
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The impact of bilateral injuries on the pathophysiology and functional outcomes of volumetric muscle loss
Volumetric muscle loss (VML)—defined as the irrecoverable loss of skeletal muscle tissue with associated persistent functional deficits—is among the...
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Low-Dose LPS Modulates Microglia/Macrophages Phenotypic Transformation to Amplify Rehabilitation Effects in Chronic Spinal Cord Injured (CSCI) Mice
Spinal cord injury (SCI) results in stalled motor function recovery under the chronic phase. One of the reasons due to the presence of ongoing...
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Circ2388 regulates myogenesis and muscle regeneration
The formation of skeletal muscle is a complex process that is coordinated by many regulatory factors, such as myogenic factors and noncoding RNAs....
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Extracellular matrix: the critical contributor to skeletal muscle regeneration—a comprehensive review
The regenerative ability of skeletal muscle (SM) in response to damage, injury, or disease is a highly intricate process that involves the...
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The spatiotemporal matching pattern of Ezrin/Periaxin involved in myoblast differentiation and fusion and Charcot-Marie-Tooth disease-associated muscle atrophy
BackgroundClinically, Charcot-Marie-Tooth disease (CMT)-associated muscle atrophy still lacks effective treatment. Deletion and mutation of...
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Skeletal muscle regeneration after extensive cryoinjury of caudal myomeres in adult zebrafish
Skeletal muscles can regenerate after minor injuries, but severe structural damage often leads to fibrosis in mammals. Whether adult zebrafish...
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Mini-MEndR: a miniaturized 96-well predictive assay to evaluate muscle stem cell-mediated repair
BackgroundFunctional evaluation of molecules that are predicted to promote stem cell mediated endogenous repair often requires in vivo transplant...
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Activation of P2Y2 Receptors Promotes Neuromuscular Junction Formation during Muscle Reinnervation
AbstractExtracellular adenosine 5′-triphosphate (ATP), as neurotransmitter, is known to be an activity-dependent signaling molecule that regulates...
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Circulating TGF-β1 Levels: Linking Muscle and Trauma
Transforming growth factor-beta 1 (TGF-β1) is a multifunctional growth factor that plays a key role in a variety of human tissues. Three TGF-β1...