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A novel chronic dural port platform for continuous collection of cerebrospinal fluid and intrathecal drug delivery in free-moving mice
BackgroundCerebrospinal fluid (CSF) provides a close representation of pathophysiological changes occurring in the central nervous system (CNS);...
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Ocular Injection Techniques for Retinitis Pigmentosa: Intravitreal, Subretinal, and Suprachoroidal
Ocular gene therapyGene therapies represents an emerging and promising therapeutic approach for the treatment of several of the inherited retinal...
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Pharmacokinetics and pharmacodynamics of perfluoropropane after intra-venous bolus injection of perflutren lipid microsphere injection (DEFINITY®) in healthy Chinese volunteers
Background and objectiveDefinity is an ultrasound contrast agent consisting of phospholipids-encapsulated perfluoropropane (PFP), also known as...
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Retina-to-brain spreading of α-synuclein after intravitreal injection of preformed fibrils
Parkinson’s disease (PD) is a neurodegenerative disorder characterized by the aggregation of misfolded α-synuclein and progressive spreading of the...
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Intradermal Vaccination with PLGA Nanoparticles via Dissolving Microneedles and Classical Injection Needles
PurposeA dissolving microneedle array (dMNA) is a vaccine delivery device with several advantages over conventional needles. By incorporating...
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Outer retinal transduction by AAV2-7m8 following intravitreal injection in a sheep model of CNGA3 achromatopsia
Sheep carrying a mutated CNGA3 gene exhibit diminished cone function and provide a naturally occurring large animal model of achromatopsia....
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Chronic Neuroinflammation Induced by Lipopolysaccharide Injection into the Third Ventricle Induces Behavioral Changes
The existence of Gram-negative bacteria in the brain, regardless of underlying immune status has been demonstrated by recent studies. The...
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Aqueous Humor Circulation in the Era of Minimally Invasive Surgery for Glaucoma
Glaucoma surgery with implantation of aqueous humor draining microstents may compromise long-term corneal health by disrupting aqueous humor...
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Intramuscular injection of vectorized-scFvMC1 reduces pathological tau in two different tau transgenic models
With evidence supporting the prion-like spreading of extracellular tau as a mechanism for the initiation and progression of Alzheimer’s disease (AD),...
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Convection-Enhanced Drug Delivery: Experimental and Analytical Studies of Infusion Behavior in an In Vitro Brain Surrogate
Convection-enhanced drug delivery (CED) directly infuses drugs with a large molecular weight toward target cells as a therapeutic strategy for...
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Hemodynamics of Saline Flushing in Endoscopic Imaging of Partially Occluded Coronary Arteries
PurposeIntravascular endoscopy can aid in the diagnosis of coronary atherosclerosis by providing direct color images of coronary plaques. The...
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A comparison of the chemo- and radiotoxicity of thorium and uranium at different enrichment grades
Uranium and thorium are heavy metals, and all of their isotopes are radioactive, so it is impossible to study chemical effects entirely independent...
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Trans-synaptic and retrograde axonal spread of Lewy pathology following pre-formed fibril injection in an in vivo A53T alpha-synuclein mouse model of synucleinopathy
It is necessary to develop an understanding of the specific mechanisms involved in alpha-synuclein aggregation and propagation to develop disease...
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Design Validation of a Smart Inhaler Device with an Integrated Spacer for Enhanced Aerosolization Performance
Herein, we report the development and optimization of ARI™, a smart pMDI inhaler device with integrated spacer functionality. The design was...
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Long-Acting Strategies for Antibody Drugs: Structural Modification, Controlling Release, and Changing the Administration Route
Because of their high specificity, high affinity, and targeting, antibody drugs have been widely used in the treatment of many diseases and have...
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Long-Term Constant Subcutaneous Drug Administration
In this chapter, a long-term drug delivery system for preclinical therapeutic research is introduced. By using a subcutaneously implanted ALZET®...
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Convection Enhanced Delivery of Viral Vectors
Convection-enhanced delivery (CED) is a pressure-based approach of delivering agents, such as viral vectors, throughout large regions of tissue. CED...
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Ketamine produces no detectable long-term positive or negative effects on cognitive flexibility or reinforcement learning of male rats
RationalePatients with major depressive disorder (MDD) often experience abnormalities in behavioral adaptation following environmental changes (i.e.,...
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Novel Applications of an In Vitro Injection Model System to Study Bioperformance: Case Studies with Different Drug Modalities
PurposeIn the biopharmaceutical industry, in vitro models are not commonly used to assess formulation risks of injectables. With limited knowledge,...
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Effect of Nasal Inhalation on Drug Particle Deposition and Size Distribution in the Upper Airway: With Soft Mist Inhalers
Delivery of drugs to the lungs is commonly achieved using nasal and/or oral breathing-assisted techniques. The route of inhalation can substantially...
