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TIGIT Regulates T Cell Inflammation in Airway Inflammatory Diseases
TIGIT, a co-inhibitory receptor found on T cells and NK cells, transmits inhibitory signals upon binding to its ligand. This interaction suppresses...
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Inflammatory response-based prognostication and personalized therapy decisions in clear cell renal cell cancer to aid precision oncology
ObjectiveThe impact of inflammatory response on tumor development and therapeutic response is of significant importance in clear cell renal cell...
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Synergistic effects of mesenchymal stem cell-derived extracellular vesicles and dexamethasone on macrophage polarization under inflammatory conditions
The undesirable inflammation and the excessive M1 macrophage activity may lead to inflammatory diseases. Corticosteroids and stem cell therapy are...
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Modulation of plasmacytoid dendritic cell and CD4+ T cell differentiation accompanied by upregulation of the cholinergic anti-inflammatory pathway induced by enterovirus 71
Enterovirus 71 (EV71) is a neurotropic enterovirus associated with hand, foot, and mouth disease (HFMD) fatalities. In this study, we investigated...
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The role of circulating cell-free DNA as an inflammatory mediator after stroke
Stroke is the second leading cause of death worldwide and a leading cause of disability. Clinical and experimental studies highlighted the complex...
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Chaperone- and PTM-mediated activation of IRF1 tames radiation-induced cell death and the inflammatory response
The key role of structural cells in immune modulation has been revealed with the advent of single-cell multiomics, but the underlying mechanism...
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PSMC6 induces immune cell infiltration and inflammatory response to aggravate primary Sjögren’s syndrome
Increasing evidence suggests that immune cell infiltration is involved in primary Sjögren’s syndrome (pSS), while the underlying molecular mechanisms...
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Elk1 enhances inflammatory cell infiltration and exacerbates acute lung injury/acute respiratory distress syndrome by suppressing Fcgr2b transcription
ObjectiveAcute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are associated with significant mortality rates. The role of Fcgr2b...
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Effect of luteolin on oxidative stress and inflammation in the human osteoblast cell line hFOB1.19 in an inflammatory microenvironment
BackgroundPeriapical lesions are characterized by periapical inflammation and damage to periapical tissues and eventually lead to bone resorption and...
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Multiomics Data Integration in Understanding of Inflammation and Inflammatory Diseases
Inflammation is a complex biological response to a variety of harmful stimuli, including infection and tissue damage. The diverse array of cell types...
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Antibody-Based Biotherapeutics in Inflammatory Diseases
Inflammatory diseases encompass a broad and diverse spectrum of serious chronic disorders, many of which have significant need for safe and effective...
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Inflammatory cell death PANoptosis is induced by the anti-cancer curaxin CBL0137 via eliciting the assembly of ZBP1-associated PANoptosome
ObjectivePANoptosis, a new form of regulated cell death, concomitantly manifests hallmarks for pyroptosis, apoptosis, and necroptosis. It has been...
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Immune cell infiltration and inflammatory landscape in primary brain tumours
BackgroundPrimary malignant brain tumours are more than one-third of all brain tumours and despite the molecular investigation to identify cancer...
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Innate immunity, cytokine storm, and inflammatory cell death in COVID-19
The innate immune system serves as the first line of defense against invading pathogens; however, dysregulated innate immune responses can induce...
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Oligomeric Amyloid-β and Tau Alter Cell Adhesion Properties and Induce Inflammatory Responses in Cerebral Endothelial Cells Through the RhoA/ROCK Pathway
Dysfunction of cerebral endothelial cells (CECs) has been implicated in the pathology of Alzheimer’s disease (AD). Despite evidence showing cytotoxic...
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Role of Pyroptosis, a Pro-inflammatory Programmed Cell Death, in Epilepsy
Epilepsy is one of the most common serious brain diseases worldwide. Programmed cell death (PCD), a cellular self-destruction phenomenon, has been...
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Inflammatory Mediators, Nociceptors, and Their Interactions in Pain
Inflammation produces pro-inflammatory mediators for the induction of pain. These mediators include inflammatory cytokines and chemokines, lipids,...
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Depression and Cancer: The Inflammatory Bridge
Depression has been associated with tumor pathogenesis, but the relationship between psychological factors and cancer development remains...
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Clinical Trials and Outcomes in Anti-inflammatory Therapies
Inflammatory diseases represent a diverse group of disorders stemming from an overactive immune response, affecting various organs and tissues and...
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Blockage of CXCR2 Activity Suppressed Inflammatory Cytokine Release and Ferroptosis in Rotenone-Induced SH-SY5Y Cell Model with PD-Like Lesions
AbstractParkinson’s disease (PD) is the most common neurodegenerative disease worldwide. Pesticides can cause neurotoxicity, which plays a vital role...
