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Tumor Suppressor Genes
Tumor suppressors are the second major type of cancer genes. In contrast to oncogenes, tumor suppressor genes have to undergo loss of function to...
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CDK4/6 inhibitors sensitize gammaherpesvirus-infected tumor cells to T-cell killing by enhancing expression of immune surface molecules
BackgroundThe two oncogenic human gammaherpesviruses, Kaposi sarcoma-associated herpesvirus (KSHV) and Epstein–Barr virus (EBV), both downregulate...
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Association of DOK3 and infiltrated tumor-associated macrophages with risk for the prognosis of Porphyromonas gingivalis-infected oral cancer: a 12-year data analysis of 200 patients from a tertiary teaching hospital, Urumqi, China
BackgroundWhile there is an understanding of the association between the expression of Porphyromonas gingivalis ( P. gingivalis ) and prognosis of...
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Tumor Immunology and Immunotherapy
Understanding immune mechanisms in cancer and immunotherapy has made cancer diagnosis and treatment more effective. The immune system can recognize...
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The Role of Exosomes in Tumor Metastasis
Exosomes, extracellular vesicles featuring phospholipid bilayers, play essential roles in cell–cell communication; tumor microenvironment (TME)...
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Management for persistent HPV infection and cervical lesions among women infected with HIV: a retrospective observational cohort study
BackgroundEarly diagnosis and treatment of HPV persistent infection and cervical intraepithelial neoplasia, which have yet to be thoroughly...
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Orchestration of antiviral responses within the infected central nervous system
Many newly emerging and re-emerging viruses have neuroinvasive potential, underscoring viral encephalitis as a global research priority. Upon entry...
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Generation of glioblastoma in mice engrafted with human cytomegalovirus-infected astrocytes
Mounting evidence is identifying human cytomegalovirus (HCMV) as a potential oncogenic virus. HCMV has been detected in glioblastoma multiforme (GB)....
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Approaches to Evaluating Necroptosis in Virus-Infected Cells
The immune system functions to protect the host from pathogens. To counter host defense mechanisms, pathogens have developed unique strategies to...
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Hallmarks of CD8+ T cell dysfunction are established within hours of tumor antigen encounter before cell division
Tumor-specific CD8+ T cells (TST) in patients with cancer are dysfunctional and unable to halt cancer progression. TST dysfunction, also known as...
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Human Papilloma Virus-Infected Cells
Human papillomavirus (HPV) is associated with infection of different tissues, such as the cervix, anus, vagina, penis, vulva, oropharynx, throat,...
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A Comprehensive Analysis of NRP1 in Malignancies Provide Therapeutic Implication for Treating Cancer Patients Infected with SARS-CoV-2
COVID-19 (Coronavirus disease 2019) is caused by SARS-CoV-2 (severe acute respiratory syndrome coronavirus-2), which can lead to pneumonia, cytokine...
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The opposing effect of acute and chronic Toxoplasma gondii infection on tumor development
BackgroundThe interplay between Toxoplasma gondii infection and tumor development is intriguing and not yet fully understood. Some studies showed...
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Ferroptosis crosstalk in anti-tumor immunotherapy: molecular mechanisms, tumor microenvironment, application prospects
Immunotherapies for cancer, specifically immune checkpoint inhibition (ICI), have shown potential in reactivating the body’s immune response against...
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Integrative HLA ty** of tumor and adjacent normal tissue can reveal insights into the tumor immune response
BackgroundThe HLA complex is the most polymorphic region of the human genome, and its improved characterization can help us understand the genetics...
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Primary head and neck cancer cell cultures are susceptible to proliferation of Epstein-Barr virus infected lymphocytes
BackgroundNew concepts for a more effective anti-cancer therapy are urgently needed. Experimental flaws represent a major counter player of this...
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Chemokine and Cytokine Networks in Tumor Microenvironment
A large family of tiny chemotactic cytokines direct the migration of immune cells and is known as chemokines. Chemotactic factors help the immune...
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The golden key to open mystery boxes of SMARCA4-deficient undifferentiated thoracic tumor: focusing immunotherapy, tumor microenvironment and epigenetic regulation
SMARCA4-deficient undifferentiated thoracic tumor is extremely invasive. This tumor with poor prognosis is easily confused with SMARCA4-deficent...
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Role of Immune Cells in the Tumor Microenvironment
The tumor microenvironment (TME) encloses a repertoire of immune cells besides cancer cells. The role of immune cells in the TME plays an essential...
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MiRNA Immunity Against Virus and MiRNA Surveillance Against Tumor
Through the microRNA (miRNA) entangling target sorting/quantum miRNA language plus artificial intelligence (METS/MIRAI) analysis so far, it seems...