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Neuronal activity rapidly reprograms dendritic translation via eIF4G2:uORF binding
Learning and memory require activity-induced changes in dendritic translation, but which mRNAs are involved and how they are regulated are unclear....
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Atypical Modes of CTCF Binding Facilitate Tissue-Specific and Neuronal Activity-Dependent Gene Expression States
Multivalent binding of CTCF to variable DNA sequences is thought to underlie its ability to mediate diverse cellular functions. CTCF typically binds...
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A superior extracellular matrix binding motif to enhance the regenerative activity and safety of therapeutic proteins
Among therapeutic proteins, cytokines and growth factors have great potential for regenerative medicine applications. However, these molecules have...
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BioID Analysis of Actin-Binding Proteins
Proteins often exist and function as part of higher-order complexes or networks. A challenge is to identify the universe of proximal and interacting...
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Radioligand Binding at Muscarinic Receptors
Five subtypes of muscarinic acetylcholine receptors denoted M1 through M5 mediate a wide array of physiological functions. Therefore, impairment of...
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Laboratory Testing for von Willebrand Factor Activity by a Glycoprotein Ib-Binding Assay (VWF:GPIbR): HemosIL von Willebrand Factor Ristocetin Cofactor Activity on ACL TOP®
von Willebrand disease (VWD) is a lifelong and common inherited bleeding disorder caused by a quantitative deficiency and/or qualitative defect of...
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BMS794833 inhibits macrophage efferocytosis by directly binding to MERTK and inhibiting its activity
Myeloid epithelial reproductive proto-oncogene tyrosine kinase (MERTK) plays an essential role in modulating cancer immune tolerance by regulating...
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Increase of c-FOS promoter transcriptional activity by the dual leucine zipper kinase
The dual leucine zipper kinase (DLK) and the ubiquitously expressed transcription factor c-FOS have important roles in beta-cell proliferation and...
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Unveiling poly(rC)-binding protein 2 as the target protein for curcusone C against prostate cancer: mechanism validation through click chemistry-activity based proteomics profiling approach
BackgroundProstate cancer is a disease that seriously troubles men. However, there are some inevitable limitations in interventional therapy for...
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Discovery of novel acridine-chalcone hybrids with potent DNA binding and antiproliferative activity against MDA-MB-231 and MCF-7 cells
Two series of novel chalcone derivatives containing acridin-9-yl or acridin-4-yl moiety have been synthesized, structure elucidated and further...
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Combined effects of microplastics and methylmercury on the activity of ATP-binding cassette (ABC) transporter in the brackish water flea Diaphanosoma celebensis
ObjectivesDue to their widespread presence, persistence, and bioaccumulation in living organisms, microplastics (MP) and methylmercury (MeHg)...
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IL-22 alters gut microbiota composition and function to increase aryl hydrocarbon receptor activity in mice and humans
BackgroundIL-22 is induced by aryl hydrocarbon receptor (AhR) signaling and plays a critical role in gastrointestinal barrier function through...
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RNA binding protein HuD promotes autophagy and tumor stress survival by suppressing mTORC1 activity and augmenting ARL6IP1 levels
BackgroundNeuronal-origin HuD (ELAVL4) is an RNA binding protein overexpressed in neuroblastoma (NB) and certain other cancers. The RNA targets of...
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CREB-Binding Protein Regulates Cocaine- and Amphetamine-Regulated Transcript Peptide Expression in the Lateral Hypothalamus: Implication in Reward and Reinforcement
Neuropeptide cocaine- and amphetamine-regulated transcript peptide (CARTp) is known to play an important role in reward processing. The rats...
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Effects of Bullfrog Sialic Acid–Binding Lectin in Cancer Cells
A cancer cell agglutinin isolated from bullfrog (Rana catesbeiana) eggs was named R. catesbeiana sialic acid–binding lectin (cSBL), because its...
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Clinical perspectives on the age-related increase of immunosuppressive activity
The aging process is associated with a remodeling of the immune system involving chronic low-grade inflammation and a gradual decline in the function...
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Psychedelics promote plasticity by directly binding to BDNF receptor TrkB
Psychedelics produce fast and persistent antidepressant effects and induce neuroplasticity resembling the effects of clinically approved...
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gp120-derived amyloidogenic peptides form amyloid fibrils that increase HIV-1 infectivity
Apart from mediating viral entry, the function of the free HIV-1 envelope protein (gp120) has yet to be elucidated. Our group previously showed that...
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Pathogenic variants causing ABL1 malformation syndrome cluster in a myristoyl-binding pocket and increase tyrosine kinase activity
ABL1 is a proto-oncogene encoding a nonreceptor tyrosine kinase, best known in the somatic BCR-ABL fusion gene associated with chronic myeloid...
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Multiomic profiling of transcription factor binding and function in human brain
Transcription factors (TFs) orchestrate gene expression programs crucial for brain function, but we lack detailed information about TF binding in...
