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Sexual Incentive Motivation
Motivation can be described as the processes that activate, direct, and determine the persistence of goal-directed behavior. A certain level of...
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Metabotropic glutamate group II receptor activation in the ventrolateral dorsal striatum suppresses incentive motivation for cocaine in rats
RationaleAfter a history of intermittent cocaine intake, rats develop patterns of drug use characteristic of substance use disorder. The dorsal...
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Metabotropic group II glutamate receptors in the basolateral amygdala mediate cue-triggered increases in incentive motivation
RationaleReward-associated cues can trigger incentive motivation for reward and invigorate reward-seeking behaviour via Pavlovian-to-instrumental...
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Secondary rewards acquire enhanced incentive motivation via increasing anticipatory activity of the lateral orbitofrontal cortex
The motivation to strive for and consume primary rewards such as palatable food is bound by devaluation mechanisms, yet secondary rewards such as...
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How different incentives influence reported motivation and perceptions of performance in Ghanaian community-based health planning and services zones
Background:Maternal mortality is still a burden worldwide, and Ghana’s maternal and child mortalities are still high. Incentive schemes have been...
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Uncovering the neurophysiology of mood, motivation and behavioral symptoms in Parkinson’s disease through intracranial recordings
Neuropsychiatric mood and motivation symptoms (depression, anxiety, apathy, impulse control disorders) in Parkinson’s disease (PD) are highly...
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Emotion, motivation, decision-making, the orbitofrontal cortex, anterior cingulate cortex, and the amygdala
The orbitofrontal cortex and amygdala are involved in emotion and in motivation, but the relationship between these functions performed by these...
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Is Adolescence a Sensitive Period for the Development of Incentive-Reward Motivation?
Human adolescence is broadly construed as a time of heightened risk-taking and a vulnerability period for the emergence of psychopathology. These...
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Motivation to test, treat, and report malaria cases: a quantitative assessment among private sector providers in the Greater Mekong Subregion
BackgroundAccurately testing, treating, and tracking all malaria cases is critical to achieving elimination. Ensuring health providers are able and...
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α-Dystrobrevin knockout mice have increased motivation for appetitive reward and altered brain cannabinoid receptor 1 expression
α-Dystrobrevin (α-DB) is a major component of the dystrophin-associated protein complex (DAPC). Knockout (KO) of α-DB in the brain is associated with...
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Pro-Choice: Partner Preference as a Method to Assess Sexual Motivation
The partner preference test has been used to evaluate the neurobiology of sexual motivation in animal models. Despite the variable characteristics of...
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The effects of the dopamine D2/3 agonist quinpirole on incentive value and palatability-based choice in a rodent model of attention-deficit/hyperactivity disorder
RationalePalatability and incentive value influence animal food choice. Dopamine D2/3 receptor signaling may mediate the effects of palatability and...
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Effects of inescapable stress on responses to social incentive stimuli and modulation by escitalopram
RationaleStress is a well-known risk factor for anhedonia, and its impacts on social reward functions may be mitigated by its controllability....
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Activation of G protein-coupled estradiol receptor 1 in the dorsolateral striatum enhances motivation for cocaine and drug-induced reinstatement in female but not male rats
BackgroundEstradiol potentiates drug-taking behaviors, including motivation to self-administer cocaine and reinstatement of drug-seeking after...
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Reduced Reward Processing in Schizophrenia: A Comprehensive EEG Event-Related Oscillation Study
It is well known that abnormal reward processing is a characteristic feature of various psychopathologies including schizophrenia (SZ). Reduced...
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Repeated dosing with cocaine produces strain-dependent effects on responding for conditioned reinforcement in Collaborative Cross mice
RationaleCocaine use disorder (CUD) is a highly heritable form of substance use disorder, with genetic variation accounting for a substantial...
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Effects of the cannabinoid receptor agonist CP-55,940 on incentive salience attribution
RationalePavlovian conditioned approach paradigms are used to characterize the nature of motivational behaviors in response to stimuli as either...
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Increased elasticity of sucrose demand during hyperdopaminergic states in rats
RationaleDeficits in cost–benefit decision-making are a core feature of several psychiatric disorders, including substance addiction, eating...
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Anticipation: An Essential Feature of Anhedonia
The following essay addresses the evolution of the term “anhedonia” as a key construct in biological psychiatry, especially as it pertains to...