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Distribution In Vivo
Distribution studies with radiolabeled test substances in animals are an important part of the drug development process. Traditional routine methods...
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Radionuclide Reporter Imaging to Visualize Tumor Hypoxia Ex Vivo and In Vivo
In vitro studies using cell culture, including three-dimensional cultures without the involvement of tumor vessels, have limitations in simulating...
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Application of a new MDCKII-MDR1 cell model to measure the extent of drug distribution in vitro at equilibrium for prediction of in vivo unbound brain-to-plasma drug distribution
Intro: Reliable estimates of drug uptake from blood to brain parenchyma are crucial in CNS drug discovery and development. While in vivo K p,uu,brain ...
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Formation and Analysis of Biofilms in Vivo
Establishing a biofilm infection model in vivo allows a better understanding of the underlying infection mechanisms of bacteria. Here we describe a...
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In Vitro and In Vivo Metabolism Studies
Drug metabolism studies play a critical role in the discovery and development of new chemical entities. These studies provide in-depth understanding...
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Oxygen Assessment in Tumors In Vivo Using Phosphorescence Lifetime Imaging Microscopy
The oxygen level in a tumor is a crucial factor for its development and response to therapies. Phosphorescence lifetime imaging (PLIM) with the use...
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In Vivo, Ex Vivo, and In Vitro Model Systems for Liver Cancer Research
Cancer claims the lives of millions of people worldwide. Liver cancer represents one such form of cancer that has a high incidence with a poor...
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Oleogels for the ocular delivery of epalrestat: formulation, in vitro, in ovo, ex vivo and in vivo evaluation
The ocular administration of lipophilic and labile drugs such as epalrestat, an aldose reductase inhibitor with potential for diabetic retinopathy...
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Tumor Models of Retinoblastoma: In Vivo, Ex Vivo, and In Vitro Models
In the initial simplistic understanding, childhood retinal cancer retinoblastoma is due to the defect in the retinoblastoma gene. However, the deep...
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Distinct dynamics of mRNA LNPs in mice and nonhuman primates revealed by in vivo imaging
The characterization of vaccine distribution to relevant tissues after in vivo administration is critical to understanding their mechanisms of...
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Amorphous nasal powder advanced performance: in vitro/ex vivo studies and correlation with in vivo pharmacokinetics
PurposeAmorphous solid dispersions (ASD) for nasal delivery offer the opportunity to increase drug release performance, while using polymers with...
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Mouse Brain MRI: Including In Vivo, Ex Vivo, and fcMRI for the Study of Microcephaly
With its sensitivity to soft tissue, MRI is a powerful tool for the study of the neuroanatomical manifestations of a variety of conditions, such as...
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Ex vivo, in vivo and in silico studies of corneal biomechanics: a systematic review
Healthy cornea guarantees the refractive power of the eye and the protection of the inner components, but injury, trauma or pathology may impair the...
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Fluorescent Imaging In Vivo
In this chapter we have to find answers to a number of important questions regarding the fluorescence imaging and sensing on the level of the whole...
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In Vivo and Ex Vivo Analysis of Omental Adhesion in Ovarian Cancer
In vivo and ex vivo analyses of omental adhesion in ovarian cancer (OvCa) are necessary to understand the dynamics of OvCa metastasis. Here we...
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Drug Distribution
Once in systemic circulation, the drug molecules will extravasate to other tissues, including the targeted organ(s), a process that we will refer to...
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Enhancing anti-tumor therapy with agmatine-cholesterol conjugate liposomes: in vitro and in vivo evidence
In this study, we synthesized a novel compound, agmatine-cholesterol conjugate (AG-Chol), to enhance the anti-tumor activity of drug-loaded...
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Establishing relationships between particle-induced in vitro and in vivo inflammation endpoints to better extrapolate between in vitro markers and in vivo fibrosis
BackgroundToxicity assessment for regulatory purposes is starting to move away from traditional in vivo methods and towards new approach...
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In Vivo, Ex Vivo, and In Vitro Models Systems for Liver Cancer Research
Cancer claims the lives of millions of people worldwide. Liver cancer represents one such form of cancer that has a high incidence with a poor...
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In Vivo Evaluation of BBB Integrity in the Post-stroke Brain
The blood–brain barrier (BBB) is a dynamic interface responsible for maintaining central nervous system (CNS) homeostasis. An intact BBB protects the...