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In Vitro Models and Proteomics in Osteoarthritis Research
This review summarizes and exemplifies the current understanding of osteoarthritis in vitro models and describes their relevance for new insights in...
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In Vitro Models of Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis (ALS) is one of the commonest neurodegenerative diseases of adult-onset, which is characterized by the progressive...
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Newly developed 3D in vitro models to study tumor–immune interaction
Immunotherapy as a rapidly develo** therapeutic approach has revolutionized cancer treatment and revitalized the field of tumor immunology...
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Tumor Models of Retinoblastoma: In Vivo, Ex Vivo, and In Vitro Models
In the initial simplistic understanding, childhood retinal cancer retinoblastoma is due to the defect in the retinoblastoma gene. However, the deep...
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Develo** High-Fidelity In Vitro Models of Traumatic Brain Injury to Test Therapeutic Biomaterials
Introduction: Traumatic brain injury (TBI)Traumatic Brain Injury (TBI) can cause significant disability and is a leading cause of death amongst under...
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Prediction of cytochrome P450-mediated bioactivation using machine learning models and in vitro validation
Cytochrome P450 (P450)-mediated bioactivation, which can lead to the hepatotoxicity through the formation of reactive metabolites (RMs), has been...
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The role of three-dimensional in vitro models in modelling the inflammatory microenvironment associated with obesity in breast cancer
Obesity is an established risk factor for breast cancer in postmenopausal women. However, the underlying biological mechanisms of how obesity...
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Integration of pan-omics technologies and three-dimensional in vitro tumor models: an approach toward drug discovery and precision medicine
Despite advancements in treatment protocols, cancer is one of the leading cause of deaths worldwide. Therefore, there is a need to identify newer and...
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In Vitro and In Silico ADME Prediction
Pharmacokinetic issues have been identified as a major cause for the attrition of new chemical entities in drug discovery. High development costs and...
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Neuronal Responses to Ischemia: Sco** Review of Insights from Human-Derived In Vitro Models
Translation of neuroprotective treatment effects from experimental animal models to patients with cerebral ischemia has been challenging. Since...
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In Vitro and In Vivo Host Models of Metastasis
Metastasis is a complex multi-step process that typically occurs over years, making the process challenging to accurately model in the laboratory....
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In vitro toxicology: Next generation models and methods to improve safety evaluation
With the advent of molecular and cellular toxicology, the field of drug safety evaluation has been undergoing an important paradigm shift, which has...
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Beyond animal models: revolutionizing neurodegenerative disease modeling using 3D in vitro organoids, microfluidic chips, and bioprinting
Neurodegenerative diseases (NDs) are characterized by uncontrolled loss of neuronal cells leading to a progressive deterioration of brain functions....
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In vitro models and ex vivo systems used in inflammatory bowel disease
Inflammatory bowel disease (IBD) is a chronic, relapsing gastrointestinal condition. Ulcerative colitis and Crohn’s disease are types of inflammatory...
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Ghrelin mediated cardioprotection using in vitro models of oxidative stress
Ghrelin is commonly known as the ‘hunger hormone’ due to its role in stimulating food intake in humans. However, the roles of ghrelin extend beyond...
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In vitro models to detect in vivo bile acid changes induced by antibiotics
Bile acid homeostasis plays an important role in many biological activities through the bile–liver–gut axis. In this study, two in vitro models were...
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In Vitro Models to Study Angiogenesis and Vasculature
The development of vasculature in vivo is an extremely complex process that requires temporal and spatial coordination between multiple cell types to...
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In vitro cancer models as an approach to identify targetable developmental phenotypes in cancer stem cells
Cancer therapeutics are often highly toxic to the patient, and they often elicit rapid resistance in the tumour. Recent advances have suggested a...
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3D Human Tumor Tissues Cultured in Dynamic Conditions as Alternative In Vitro Disease Models
The slow knowledge progression about cancer disease and the high drug clinical failure are mainly due to the inadequacy of the simplistic...
