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Chromosomal instability (CIN) in HAP1 cell lines revealed by multiplex fluorescence in situ hybridisation (M-FISH)
BackgroundHAP1, a near-haploid human leukemic cancer cell line is often used in combination with CRISPR-Cas9 gene editing technology for genetic...
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The puzzle of plant hybridisation: a high propensity to hybridise but few hybrid zones reported
An interesting conundrum was recently revealed by R. Abbott when he found that the number of hybrid zones reported in the literature for plants is...
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Hybridisation chain reaction-based visualisation and screening for lncRNA profiles in clear-cell renal-cell carcinoma
BackgroundAnalysis of long noncoding RNA (lncRNA) localisation at both the tissue and subcellular levels can provide important insights into the cell...
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α-Fetoprotein mRNA in situ hybridisation is a highly specific marker of hepatocellular carcinoma: a multi-centre study
BackgroundPathologic diagnosis of hepatocellular carcinoma (HCC) can be challenging in differentiating from benign and non-hepatocytic malignancy...
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Parvicapsula pseudobranchicola in the northeast Pacific Ocean is rare in farmed Atlantic salmon Salmo salar despite widespread occurrence and pathology in wild Pacific salmon Oncorhynchus spp.
BackgroundInfection with the myxozoan parasite Parvicapsula pseudobranchicola causes disease in wild and farmed salmonids in Norway. In the...
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Microarray analysis of ductal carcinoma in situ samples obtained by puncture from surgical resection specimens
ObjectiveThe incidence of ductal carcinoma in situ (DCIS) is increasing due to more widespread mammographic screening. DCIS, the earliest form of...
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Anatomical characterisation of three different psychosurgical targets in the subthalamic area: from the basal ganglia to the limbic system
Effective neural stimulation for the treatment of severe psychiatric disorders needs accurate characterisation of surgical targets. This is...
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Immunohistochemical localisation of vasopressin/oxytocin-type, corazonin-type and luqin-type neuropeptide expression in the starfish Asterias rubens using antibodies to the C-terminal region of precursor proteins
Neuropeptides derived from larger precursor proteins are secreted as signalling molecules by neurons and regulate diverse physiological and...
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Mast cell marker gene signature in head and neck squamous cell carcinoma
BackgroundMast cells can reshape the tumour immune microenvironment and greatly affect tumour occurrence and development. However, mast cell gene...
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Estimating the prevalence of Epstein–Barr virus in primary gastric lymphoma: a systematic review and meta-analysis
The stomach is a common site for extranodal non-Hodgkin’s lymphoma. While Helicobacter pylori ( H. pylori ) is the main established risk factor for...
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Visualisation of Host–Pathogen Communication
The core of biomedical science is the use of laboratory techniques to support the diagnosis and treatment of disease in clinical settings. Despite...
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Cytokine enrichment in deep cerebellar nuclei is contributed by multiple glial populations and linked to reduced amyloid plaque pathology
Alzheimer’s disease (AD) pathology and amyloid-beta (Aβ) plaque deposition progress slowly in the cerebellum compared to other brain regions, while...
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Expression analysis of peptidergic enteroendocrine cells in the silkworm Bombyx mori
Enteroendocrine cells (ECs) in the insect midgut respond to physiological changes in the intestine by releasing multiple peptides to control food...
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Spatial tumour gene signature discriminates neoplastic from non-neoplastic compartments in colon cancer: unravelling predictive biomarkers for relapse
BackgroundOpting for or against the administration of adjuvant chemotherapy in therapeutic management of stage II colon cancer remains challenging....
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Predicting the HER2 status in oesophageal cancer from tissue microarrays using convolutional neural networks
BackgroundFast and accurate diagnostics are key for personalised medicine. Particularly in cancer, precise diagnosis is a prerequisite for targeted...
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Genomics, Proteomics and Molecular Biology in Microbiology
The science of microbiology had relied for a long time on phenotypic markers such as culture, morphology, biochemical and serological properties of...
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Galaninergic and hypercapnia-activated neuronal projections to the ventral respiratory column
In mammals, the ventral respiratory column (VRC) plays a pivotal role in integrating neurochemically diverse inputs from brainstem and forebrain...
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atoh8 expression pattern in early zebrafish embryonic development
Atonal homologue 8 ( atoh8 ) is a basic helix-loop-helix transcription factor expressed in a variety of embryonic tissues. While several studies have...
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A case of complex balanced chromosomal translocations associated with adverse pregnancy outcomes
Complex chromosomal rearrangements (CCR) are rare chromosomal structural abnormalities. The chromosomal structural variants in CCR carriers are one...
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The clinical significance of oestrogen receptor expression in breast ductal carcinoma in situ
BackgroundOestrogen receptor (ER) in invasive breast cancer (BC) predicts response to endocrine therapy (ET) and provides prognostic value. In this...
