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Neuroendocrine Basis of Impaired Mothering in Rodents
The maternal bond is the most important pro-social bond in female mammals, and its quality can affect the well-being of both infant and mother. Her...
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Impaired proprioception and magnified scaling of proprioceptive error responses in chronic stroke
BackgroundPrevious work has shown that ~ 50–60% of individuals have impaired proprioception after stroke. Typically, these studies have identified...
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Robot-aided assessment and associated brain lesions of impaired ankle proprioception in chronic stroke
BackgroundImpaired ankle proprioception strongly predicts balance dysfunction in chronic stroke. However, only sparse data on ankle position sense...
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Association of impaired sensitivity to thyroid hormones with hyperuricemia through obesity in the euthyroid population
BackgroundImpaired sensitivity to thyroid hormones is a newly proposed clinical entity associated with hyperuricemia in the subclinical hypothyroid...
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Impaired angiogenesis in ageing: the central role of the extracellular matrix
Each step in angiogenesis is regulated by the extracellular matrix (ECM). Accumulating evidence indicates that ageing-related changes in the ECM...
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Targeting CXCR4 impaired T regulatory function through PTEN in renal cancer patients
BackgroundTregs trafficking is controlled by CXCR4. In Renal Cell Carcinoma (RCC), the effect of the new CXCR4 antagonist, R54, was explored in...
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JNK inhibition enhances cell–cell adhesion impaired by desmoglein 3 gene disruption in keratinocytes
c-Jun NH 2 -terminal protein kinase (JNK) and p38 are stress-activated mitogen-activated protein kinases (MAPK) that are phosphorylated by various...
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Involvement of dysregulated hippocampal histone H3K9 methylation at the promoter of the BDNF gene in impaired memory extinction
RationaleSince the precise mechanisms of posttraumatic stress disorder (PTSD) remain unknown, effective treatment interventions have not yet been...
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Proteomic signatures for identification of impaired glucose tolerance
The implementation of recommendations for type 2 diabetes (T2D) screening and diagnosis focuses on the measurement of glycated hemoglobin (HbA1c) and...
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Prenatal Exposure to General Anesthesia Drug Esketamine Impaired Neurobehavior in Offspring
Prenatal exposure to anesthetics has raised increasing attention about the neuronal development in offspring. Animal models are usually used for...
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Cortical Deficits are Correlated with Impaired Stereopsis in Patients with Strabismus
In this study, we explored the neural mechanism underlying impaired stereopsis and possible functional plasticity after strabismus surgery. We...
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Impaired foot placement strategy during walking in people with incomplete spinal cord injury
BackgroundImpaired balance during walking is a common problem in people with incomplete spinal cord injury (iSCI). To improve walking capacity, it is...
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Impaired ATP hydrolysis in blood plasma contributes to age-related neutrophil dysfunction
BackgroundThe function of polymorphonuclear neutrophils (PMNs) decreases with age, which results in infectious and inflammatory complications in...
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Central precuneus lesions are associated with impaired executive function
The functional roles of the precuneus are unclear. Focal precuneus lesions are rare, making it difficult to identify robust brain–behavior...
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Impaired parasympathetic function in long-COVID postural orthostatic tachycardia syndrome – a case-control study
PurposeEighty percent of patients infected by SARS-CoV-2 report persistence of one symptom beyond the 4-week convalescent period. Those with...
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Impaired insulin signalling and allostatic load in Alzheimer disease
The discovery of insulin in 1921 revolutionized the treatment of diabetes and paved the way for numerous studies on hormone signalling networks and...
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Cerebrospinal fluid amyloid-β and cerebral microbleed are associated with distinct neuropsychiatric sub-syndromes in cognitively impaired patients
BackgroundNeuropsychiatric symptoms (NPS) are prevalent in cognitively impaired individuals including Alzheimer’s disease (AD) dementia and mild...
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Axonal Degeneration, Impaired Axonal Transport, and Synaptic Dysfunction in Motor Neuron Disorder
Motor neuron diseases (MNDs) are progressive disorders of the neurological system that have a strong effect on upper and lower motor neuron systems....
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A Novel CDC42 Variant with Impaired Thymopoiesis, IL-7R Signaling, PAK1 Binding, and TCR Repertoire Diversity
Genetic variants in cell division cycle 42 (CDC42) can manifest with dysmorphic features, autoinflammation, hemophagocytic lymphohistiocytosis, and...
