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Rise of the natural red pigment ‘prodigiosin’ as an immunomodulator in cancer
Cancer is a heterogeneous disease with multifaceted drug resistance mechanisms (e.g., tumour microenvironment [TME], tumour heterogeneity, and immune...
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Itaconate: A Potent Macrophage Immunomodulator
With advances in immunometabolic studies, more and more evidence has shown that metabolic changes profoundly affect the immune function of...
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Reparative and Antioxidant Effects of New Analogues of Immunomodulator Thymogen in Experimental Model of Liver Damage
We studied the reparative and antioxidant effects of Thymogen and its new structural analogues obtained by binding amino acid D-Ala to the N- or...
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Technological Map** of Plant-Derived Immunomodulator Drugs: A Patent-Guided Overview about Species and its Main Compounds
Research on natural products has investigated and employed many (bio)technologies to find out plant active fractions and optimize extraction and...
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The epigenetic immunomodulator, HBI-8000, enhances the response and reverses resistance to checkpoint inhibitors
BackgroundTreatment with immune checkpoint inhibitors (ICIs) targeting CTLA-4 and the PD-1/PD-L1 axis is effective against many cancer types....
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Pathway and Genomics of Immunomodulator Natural Products
Immune dysfunction has become a major public health problem, so the search for natural products with efficacy, safety, and therapeutic effects on the...
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Phytochemicals as the Source of Natural Immunomodulator and Their Role in Cancer Chemoprevention
A well-functioning immune system of the host body plays critical role in the upkeep of regular biological and immunological functions as well as...
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Melatonin and multiple sclerosis: antioxidant, anti-inflammatory and immunomodulator mechanism of action
BackgroundMelatonin is an indole hormone secreted primarily by the pineal gland that showing anti-oxidant, anti-inflammatory and anti-apoptotic...
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Melatonin as an immunomodulator in CD19-targeting CAR-T cell therapy: managing cytokine release syndrome
BackgroundChimeric antigen receptor CAR-T cell therapies have ushered in a new era of treatment for specific blood cancers, offering unparalleled...
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ITGBL1 is a new immunomodulator that favors development of melanoma tumors by inhibiting natural killer cells cytotoxicity
Resistances to immunotherapies remains a major hurdle towards a cure for melanoma in numerous patients. An increase in the mesenchymal phenotype and...
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The use of alpha 1 thymosin as an immunomodulator of the response against SARS-Cov2
BackgroundSince the beginning of SARS-CoV2 pandemic, the mortality rate among elderly patients (60–90 years) has been around 50%, so age has been a...
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The Role of Immunomodulator Betaleukin in Recovery of Hepatocytic Ploidy Profile in Delayed Terms after Irradiation
We studied the radioprotective effect of betaleukin administered to (CBA×C57Bl/6)F1 mice in single doses of 50 and 3 μg/kg 2 and 22 h, respectively,...
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Protocol for Evaluating In Vivo the Activation of the P2RX7 Immunomodulator
BackgroundP2RX7 is a purinergic receptor with pleiotropic activities that is activated by high levels of extracellular ATP that are found in inflamed...
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Equecabtagene Autoleucel: First Approval
Equecabtagene autoleucel (Fucaso ® ), an autologous anti-B cell maturation antigen (BCMA)-directed chimeric antigen receptor (CAR)-T cell therapy that...
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Colchicine and Andrographolide as Natural Immunomodulators
Conceptually, a promotion of appropriate immune reaction to foreign body will help in the management of the medical disorder. The immunomodulating...
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Evaluation of the therapeutic regimen in COVID-19 in transplant patients: where do immunomodulatory and antivirals stand?
BackgroundThe management of COVID-19 in organ transplant recipients is among the most imperative, yet less discussed, issues based on their...
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Correction to: ITGBL1 is a new immunomodulator that favors development of melanoma tumors by inhibiting natural killer cells cytotoxicity
An amendment to this paper has been published and can be accessed via the original article.
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Depression and Cancer: The Inflammatory Bridge
Depression has been associated with tumor pathogenesis, but the relationship between psychological factors and cancer development remains...
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Malignancy risk in individuals with familial adenomatous polyposis receiving biologics and immunomodulators
Clinicians may be hesitant to prescribe biologics or immunomodulators to individuals with familial adenomatous polyposis (FAP) and comorbid...
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Insights into the Modulation of Immune Response, Chemistry, and Mechanisms of Action of Immunomodulatory Phytomolecules
Modulators are defined as substances of different chemical natures that act together or in an antagonistic manner to initiate, maintain, reduce, and...