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Effect of Multidrug Resistance Gene and AGTR1 (1166A>C) Gene Polymorphism on Hypertension and Its Relationship with Antihypertensive Effect of Valsartan
AbstractTo analyze the relationship between the gene polymorphism of multidrug resistance gene and AGTR1 (1166A>C) gene and the susceptibility...
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Genome-Wide Identification and Analysis of the CCoAOMT Gene Family Revealed Its Relationship to Pomegranate Seed Hardness
AbstractCaffeoyl coenzyme A-O-methyltransferase (CCoAOMT) has a critical function in the lignin biosynthesis pathway. However, its role in...
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Nanodelivery in Gene Therapy
Gene therapy stands as a revolutionary approach in medicine, aiming to rectify genetic abnormalities by introducing therapeutic genes or regulating...
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Molecular Characterization and Seasonal Variation in Expression of HSP70.1 Gene in Gangatiri Cattle and Its Comparison with Buffalo
Under tropical climate heat stress is a major challenge for livestock production. HSP70.1 is a ubiquitously expressed protein maintaining cellular...
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Gene Expression and Chromatin
In this chapter, principles of gene expression are discussed. An essential condition that a gene can be expressed, i.e., transcribed into RNA, is...
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Principles of Therapeutics and Gene-Based Therapy
This chapter focuses on the history and evolution of gene-based therapies from its inception in the early 1970s to the landmark discovery of the...
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Characterization of the Ictalurid herpesvirus 1 immediate-early gene ORF24 and its potential role in transcriptional regulation in yeast
Herpesvirusesadhere to a precise temporal expression model in which immediate-early (IE) genes play a crucial role in regulating the viral life...
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Integrated mendelian randomization analyses highlight AFF3 as a novel eQTL-mediated susceptibility gene in renal cancer and its potential mechanisms
BackgroundsA growing number of expression quantitative trait loci (eQTLs) have been found to be linked with tumorigenesis. In this article, we...
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Dissecting the Immune System through Gene Regulation
The immune system plays a dual role in human health, functioning both as a protector against pathogens and, at times, as a contributor to disease....
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Muscular Dystrophy: Mutations in the Dystrophin Gene
Muscular dystrophy (MD) is a heterogeneous group of genetic disorders characterized by progressive muscle degeneration and weakness, leading to...
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Assessment of genetic diversity of Trypanosoma evansi in the domestic animal populations through ITS-1 gene sequence analysis
Trypanosoma evansi infects domestic animals, causing a debilitating and occasionally fatal disease. The disease leads to significant economic losses...
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Analysis of CYP2C19 Gene Genotype in Patients with Acute Cerebral Infarction and Its Relationship with Disease Progression
AbstractThe study aimed to analyze the polymorphism distribution of CYP2C19 gene in patients with acute cerebral infarction, and to explore its...
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Gene Therapy and Cardiovascular Diseases
Cardiovascular diseases (CVDs) are the leading causes of death globally and urgently require new novel therapeutic strategies. Gene therapy is the...
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Identification of necroptosis-related gene TRAF5 as potential target of diagnosing atherosclerosis and assessing its stability
BackgroundAtherosclerosis (AS) is a leading cause of morbidity and mortality in older patients and features progressive formation of plaques in...
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Gene Therapy in Molecular Biology and Drug Delivery
The objective of gene therapy is to manipulate/modify the gene expression or modify living cell characteristics for therapeutic utilization. It aims...
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Amyotrophic Lateral Sclerosis-Related Gene Interactions with Fat Mass and Obesity-Associated Gene
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder, characterized by rapid progressive paralysis and death within a few...
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Chromosomal Location of the b-Amy-A1 Gene and Distribution of Its Alleles in a Winter Common Wheat Culture
AbstractThe chromosomal location of the b-Amy-A1 gene, which controls the synthesis of wheat beta-amylase isoenzymes, was analyzed by assessing the...
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Methyl CpG binding protein MBD2 has a regulatory role on the BRCA1 gene expression and its modulation by resveratrol in ER+, PR+ & triple-negative breast cancer cells
BackgroundResveratrol has demonstrated its ability to regulate BRCA1 gene expression in breast cancer cells, and previous studies have established...
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Amyotrophic Lateral Sclerosis-Related Gene Interactions with Fat Mass and Obesity-Associated Gene
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder, characterized by rapid progressive paralysis and death within a few...