Search
Search Results
-
Immunity-related GTPase IRGM at the intersection of autophagy, inflammation, and tumorigenesis
The human immunity-related GTPase M (IRGM) is a GTP-binding protein that regulates selective autophagy including xenophagy and mitophagy. IRGM...
-
PRKAA2, MTOR, and TFEB in the regulation of lysosomal damage response and autophagy
Lysosomes function as critical signaling hubs that govern essential enzyme complexes. LGALS proteins (LGALS3, LGALS8, and LGALS9) are integral to the...
-
IRGM1 links mitochondrial quality control to autoimmunity
Mitochondrial abnormalities have been noted in lupus, but the causes and consequences remain obscure. Autophagy-related genes ATG5 , ATG7 and IRGM ...
-
Epigenetic and metabolic reprogramming in inflammatory bowel diseases: diagnostic and prognostic biomarkers in colorectal cancer
Background and aim"Inflammatory bowel disease" (IBD) is a chronic, relapsing inflammatory disease of the intestinal tract that typically begins at a...
-
The relationship between extreme inter-individual variation in macrophage gene expression and genetic susceptibility to inflammatory bowel disease
The differentiation of resident intestinal macrophages from blood monocytes depends upon signals from the macrophage colony-stimulating factor...
-
Reversine exerts cytotoxic effects through multiple cell death mechanisms in acute lymphoblastic leukemia
PurposeAcute lymphoblastic leukemia (ALL) is an aggressive hematological cancer with limited therapeutic options for adult patients. Aurora kinases...
-
The possible role of particulate matter on the respiratory microbiome: evidence from in vivo to clinical studies
Environmental pollution, which contains ambient particulate matter, has been shown to have a significant impact on human health and longevity over...
-
IFN-induced cell-autonomous immune mechanisms in the control of intracellular protozoa
Vertebrate cells have evolved an elaborate multi-tiered intracellular surveillance system linked to downstream antimicrobial effectors to defend...
-
Methods to Evaluate the Effects of Synonymous Variants
Degeneracy of the genetic code enables a majority of amino acids to be encoded by multiple codons, called synonymous codons. Synonymous variants are...
-
Regulation of eosinophil functions by autophagy
Eosinophils are granule-containing leukocytes which develop in the bone marrow. For many years, eosinophils have been recognized as cytotoxic...
-
Autophagy plays a double-edged sword role in liver diseases
As a highly evolutionarily conserved process, autophagy can be found in all types of eukaryotic cells. Such a constitutive process maintains cellular...
-
A haplotypic variant at the IRGM locus and rs11747270 are related to the susceptibility for chronic periodontitis
Objective and designImmunity-regulated GTPase M (IRGM) plays a critical role in the defense against intracellular bacteria by regulating autophagy...
-
Oxidative Stress-Induced Autophagy
The term “autophagy” was first coined by Christian de Duve in 1965, on observation of increased number of lysosomes in rat liver cells after the...
-
Oxidative Stress-Induced Autophagy
The term “autophagy” was first coined by Christian de Duve in 1965, on observation of increased number of lysosomes in rat liver cells after the...
-
Autophagy Balances Neuroinflammation in Alzheimer’s Disease
Autophagy is a highly evolutionary conserved process that degrades cytosolic macromolecules or damaged organelles (e.g., mitochondria), as well as...
-
Autophagy as a Target for Host-Directed Therapy Against Tuberculosis
Autophagy is the cellular self-degradative process crucial for the maintenance of homeostasis. Recent developments in the field highlight its...
-
Targeting Host and Bacterial Signaling Pathways in Tuberculosis: An Effective Strategy for the Development of Novel Anti-tubercular Therapies
Tuberculosis (TB) is a pandemic disease caused by an obligate intracellular pathogen Mycobacterium tuberculosis (M.tb). The current TB therapy,...
-
The genetics of non-monogenic IBD
Inflammatory bowel disease (IBD), with Crohn’s disease and ulcerative colitis as main subtypes, is a prototypical multifactorial disease with both...
-
Autophagy Gene BECN1 Intronic Variant rs9890617 Predisposes Individuals to Hepatitis B Virus Infection
Beclin 1 protein encoded by the BECN1 gene plays a critical role in the autophagy pathway which is utilized by the Hepatitis B virus (HBV) for its...
-
Autophagy in Cellular Stress Responses
Autophagy is an essential cellular mechanism involving the lysosomal degradation of cytoplasmic organelles or cytosolic components. Autophagy can be...