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IRAK-M Regulates Proliferative and Invasive Phenotypes of Lung Fibroblasts
Lung fibroblasts play an important role in subepithelial fibrosis, one feature for airway remodeling. IL-1 receptor-associated kinase (IRAK)-M was...
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IRAK-M Plays A Role in the Pathology of Amyotrophic Lateral Sclerosis Through Suppressing the Activation of Microglia
Microglial activation plays a crucial role in the disease progression in amyotrophic lateral sclerosis (ALS). Interleukin receptor-associated...
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Regulation of Inflammation by IRAK-M Pathway Can Be Associated with nAchRalpha7 Activation and COVID-19
In spite of the vaccine development and its importance, the SARS-CoV-2 pandemic is still impacting the world. It is known that the COVID-19 severity...
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IRAK-M Ablation Promotes Status Epilepticus-Induced Neuroinflammation via Activating M1 Microglia and Impairing Excitatory Synaptic Function
Epilepsy is one of the most common neurological disorders. The pro-epileptic and antiepileptic roles of microglia have recently garnered significant...
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α7-Acetylcholine Receptor Signaling Reduces Neuroinflammation After Subarachnoid Hemorrhage in Mice
Aneurysmal subarachnoid hemorrhage (aSAH) causes a robust inflammatory response which leads worse brain injury and poor outcomes. We investigated if...
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Naïve Huntington’s disease microglia mount a normal response to inflammatory stimuli but display a partially impaired development of innate immune tolerance that can be counteracted by ganglioside GM1
Chronic activation and dysfunction of microglia have been implicated in the pathogenesis and progression of many neurodegenerative disorders,...
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Targeting toll-like receptor 7/8 for immunotherapy: recent advances and prospectives
Toll-like receptors (TLRs) are a large family of proteins that are expressed in immune cells and various tumor cells. TLR7/8 are located in the...
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IRAK1 Duplication in MECP2 Duplication Syndrome Does Not Increase Canonical NF-κB–Induced Inflammation
PurposeBesides their developmental and neurological phenotype, most patients with MECP2/IRAK1 duplication syndrome present with recurrent and severe...
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Inflammation as a shared mechanism of chronic stress related disorders with potential novel therapeutic targets
Stress is a subjective experience that varies across individuals depending on their sensitivity, resilience, and length of exposure to stressors....
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Formulation and in-silico study of meclizine ointment as anti-eczema
Meclizine is antihistamine and is used in combination with pyridoxine to treat motion sickness. The in-silico study of meclizine prediction studied...
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Exacerbating effects of single-dose acute ethanol exposure on neuroinflammation and amelioration by GPR110 (ADGRF1) activation
BackgroundNeuroinflammation is a widely studied phenomenon underlying various neurodegenerative diseases. Earlier study demonstrated that...
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CRISPR-Cas9-Induced Gene Editing in Primary Human Monocytes
Monocytes play important and diverse roles in both homeostatic and inflammatory immune responses. The CRISPR-Cas9 system in lentiviral vectors has...
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Oxomollugin, an oxidized substance in mollugin, inhibited LPS-induced NF-κB activation via the suppressive effects on essential activation factors of TLR4 signaling
Oxomollugin is a degraded product of mollugin and was found to be an active compound that inhibits LPS-induced NF-κB activation. In this study, we...
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Regulatory effects of a novel cysteine protease inhibitor in Baylisascaris schroederi migratory larvae on mice immune cells
BackgroundThe giant panda ( Ailuropoda melanoleuca ) is a well-known, rare and endangered species. Baylisascaris schroederi is a pathogenic ascarid....
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The role of Toll-like receptors and neuroinflammation in Parkinson’s disease
BackgroundParkinson’s disease (PD) is the second most prevalent neurodegenerative disorder, characterized by motor and non-motor symptoms,...
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Neuropsychological Deficits in Disordered Screen Use Behaviours: A Systematic Review and Meta-analysis
Over the last few decades, excessive and disordered screen use has become more prevalent, prompting investigations into its associated consequences....
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Potential therapeutic strategies for myocardial infarction: the role of Toll-like receptors
Myocardial infarction (MI) is a life-threatening condition among patients with cardiovascular diseases. MI increases the risk of stroke and heart...
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Lipopolysaccharide induced altered signaling pathways in various neurological disorders
Neuroinflammation is defined as an inflammatory response within the brain or spinal cord, whereas the brain’s innate immune system is triggered by...
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Regulation of toll-like receptor (TLR) signaling pathways in atherosclerosis: from mechanisms to targeted therapeutics
Atherosclerosis, one of the life-threatening cardiovascular diseases (CVDs), has been demonstrated to be a chronic inflammatory disease, and...
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