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A new integrative analysis of histopathology and single cell RNA-seq reveals the CCL5 mediated T and NK cell interaction with vascular cells in idiopathic pulmonary arterial hypertension
BackgroundInflammation and dysregulated immunity play vital roles in idiopathic pulmonary arterial hypertension (IPAH), while the mechanisms that...
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Rare variant analysis of 4241 pulmonary arterial hypertension cases from an international consortium implicates FBLN2, PDGFD, and rare de novo variants in PAH
BackgroundPulmonary arterial hypertension (PAH) is a lethal vasculopathy characterized by pathogenic remodeling of pulmonary arterioles leading to...
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Pulmonary Hypertension
The progressive and devastating disorder of pulmonary hypertension is associated with vascular remodelling and vascular rarefaction. This escalates...
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Protein O-GlcNAcylation in cardiovascular diseases
O -GlcNAcylation is a post-translational modification of protein in response to genetic variations or environmental factors, which is controlled by...
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Novel risk genes and mechanisms implicated by exome sequencing of 2572 individuals with pulmonary arterial hypertension
BackgroundGroup 1 pulmonary arterial hypertension (PAH) is a rare disease with high mortality despite recent therapeutic advances. Pathogenic...
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Recent advances in endothelial colony-forming cells: from the transcriptomic perspective
Endothelial colony-forming cells (ECFCs) are progenitors of endothelial cells with significant proliferative and angiogenic ability. ECFCs are a...
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Unraveling the epigenetic landscape of pulmonary arterial hypertension: implications for personalized medicine development
Pulmonary arterial hypertension (PAH) is a multifactorial disease associated with the remodeling of pulmonary blood vessels. If left unaddressed, PAH...
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Inhibition of the prolyl isomerase Pin1 improves endothelial function and attenuates vascular remodelling in pulmonary hypertension by inhibiting TGF-β signalling
Pulmonary arterial hypertension (PAH) is a devastating disease, characterized by obstructive pulmonary vascular remodelling ultimately leading to...
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Nets, pulmonary arterial hypertension, and thrombo-inflammation
AbstractPulmonary arterial hypertension (PAH) is a progressive and fatal vascular disease in which high blood pressure in the pulmonary artery and...
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Cytokines, Chemokines, and Inflammation in Pulmonary Arterial Hypertension
According to the World Symposium Pulmonary Hypertension (WSPH) classification, pulmonary hypertension (PH) is classified into five categories based...
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Non-coding RNAs regulating mitochondrial function in cardiovascular diseases
Cardiovascular disease (CVD) is the leading cause of disease-related death worldwide and a significant obstacle to improving patients’ health and...
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Inflammation in Pulmonary Arterial Hypertension
Pulmonary artery hypertension (PAH) is a devastating cardiopulmonary disease characterized by vascular remodeling and obliteration of the...
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Prostacyclin (PGI2) scaffolds in medicinal chemistry: current and emerging drugs
Prostacyclin (PGI 2 ) is a natural hormone that has primarily been explored for its potent vasodilation activity and inhibition of platelet...
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The role of vasculature and angiogenesis in respiratory diseases
In European countries, nearly 10% of all hospital admissions are related to respiratory diseases, mainly chronic life-threatening diseases such as...
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Targeting Molecular and Cellular Mechanisms of Pulmonary Arterial Hypertension
Pulmonary arterial hypertension (PAH) is a devastating disease of the pulmonary circulation, characterized by pulmonary vascular remodeling leading...
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Salmonella and Shigella
Salmonellae are ubiquitous human and animal pathogens. Salmonella spp. include Gram-negative, flagellated and facultative anaerobic bacilli...
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Short reads-based characterization of pathotype diversity and drug resistance among Escherichia coli isolated from patients attending regional referral hospitals in Tanzania
BackgroundEscherichia coli is known to cause about 2 million deaths annually of which diarrhea infection is leading and typically occurs in children...