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Computational model of the spatiotemporal synergetic system dynamics of calcium, IP3 and dopamine in neuron cells
The functioning of several cellular processes in neuron cells relies on the interplay between multiple systems, such as calcium ([Ca 2+ ]), inositol 1,...
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Disrupted Ca2+ homeostasis and immunodeficiency in patients with functional IP3 receptor subtype 3 defects
Calcium signaling is essential for lymphocyte activation, with genetic disruptions of store-operated calcium (Ca 2+ ) entry resulting in severe...
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COVID-19 diagnosis using chest CT scans and deep convolutional neural networks evolved by IP-based sine-cosine algorithm
The prevalence of the COVID-19 virus and its variants has influenced all aspects of our life, and therefore, the precise diagnosis of this disease is...
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Extracellular CIRP Induces Calpain Activation in Neurons via PLC-IP3-Dependent Calcium Pathway
Abnormal calcium homeostasis, activation of protease calpain, generation of p25 and hyperactivation of cyclin-dependent kinase 5 (Cdk5) have all been...
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Derivation and characterization of an HIV-1 mutant that rescues IP6 binding deficiency
BackgroundA critical step in the HIV-1 replication cycle is the assembly of Gag proteins to form virions at the plasma membrane. Virion assembly and...
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IP-10 and MCP-1 as biomarkers associated with disease severity of COVID-19
BackgroundCOVID-19 is a viral respiratory disease caused by the severe acute respiratory syndrome-Coronavirus type 2 (SARS-CoV-2). Patients with this...
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Mibefradil alters intracellular calcium concentration by activation of phospholipase C and IP3 receptor function
Mibefradil is a tetralol derivative originally developed as an antagonist of T-type voltage-gated calcium (Ca 2+ ) channels to treat hypertension when...
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Minimal contribution of IP3R2 in cardiac differentiation and derived ventricular-like myocytes from human embryonic stem cells
Type 2 inositol 1,4,5-trisphosphate receptor (IP 3 R2) regulates the intracellular Ca 2+ release from endoplasmic reticulum in human embryonic stem...
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EEG-IP: an international infant EEG data integration platform for the study of risk and resilience in autism and related conditions
BackgroundEstablishing reliable predictive and diganostic biomarkers of autism would enhance early identification and facilitate targeted...
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Impostor Phenomenon and Grit as Predictors of Job Satisfaction in Female Pharmacy Faculty
IntroductionImpostor phenomenon (IP), grit, and other factors impact job satisfaction for faculty, particularly female faculty.
Methods ...
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Break-up and recovery of harmony between direct and indirect pathways in the basal ganglia: Huntington’s disease and treatment
The basal ganglia (BG) in the brain exhibit diverse functions for motor, cognition, and emotion. Such BG functions could be made via competitive...
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Pneumocystis jirovecii with high probability detected in bronchoalveolar lavage fluid of chemotherapy-related interstitial pneumonia in patients with lymphoma using metagenomic next-generation sequencing technology
BackgroundPrevious studies achieved low microbial detection rates in lymphoma patients with interstitial pneumonia (IP) after chemotherapy. However,...
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Effect of erythrophagocytosis-induced ferroptosis during angiogenesis in atherosclerotic plaques
Intraplaque (IP) angiogenesis is a key feature of advanced atherosclerotic plaques. Because IP vessels are fragile and leaky, erythrocytes are...
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Dynamic Control of the Output Characteristics of an Inductive Power Supply System for Implants with a Class E Power Amplifier
Displacement of the transmitting and receiving coils in inductive power (IP) supply systems with a class E power amplifier (PA) leads to changes in...
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Quantifying harmony between direct and indirect pathways in the basal ganglia: healthy and Parkinsonian states
The basal ganglia (BG) show a variety of functions for motor and cognition. There are two competitive pathways in the BG; direct pathway (DP) which...
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The insular cortex is not insular in thyroid eye disease: neuroimaging revelations of central–peripheral system interaction
BackgroundThyroid eye disease (TED) is highly correlated with dysregulated immunoendocrine status. The insular cortex was found to regulate...
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An In Vitro Study for the Role of Schizophrenia-Related Potential miRNAs in the Regulation of COMT Gene
This study aimed to analyze the possible association of miR-30a-5p, miR-30e-5p, and miR-34a-5p identified as potential candidate miRNAs in...
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An efficient molecular genetic testing strategy for incontinentia pigmenti based on single-tube long fragment read sequencing
Incontinentia pigmenti (IP) is a rare X-linked dominant neuroectodermal dysplasia that primarily affects females. The only known causative gene is IKBKG...
