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Characterization of choroid plexus in the preterm rabbit pup following subcutaneous administration of recombinant human IGF-1/IGFBP-3
Insulin-like growth factor-1 (IGF-1) is essential for normal brain development and regulates essential processes of vascular maturation and...
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Serum IGF-1 in patients with rheumatoid arthritis: correlation with disease activity
ObjectiveInsulin-like growth factor (IGF)-1 participates in modulating immunity and inflammation. Its bioactivity is controlled by six IGF-binding...
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Circulating free insulin-like growth factor-I and prostate cancer: a case-control study nested in the European prospective investigation into cancer and nutrition
BackgroundCirculating total insulin-like growth factor-I (IGF-I) is an established risk factor for prostate cancer. However, only a small proportion...
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Hormonal patterns in men with prediabetes and diabetes in NHANES III: possible links with prostate cancer
PurposePathways involving sex hormones and insulin-like growth factors (IGFs) have been proposed to explain, in part, the lower risk of prostate...
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Interaction of the AKT and β-catenin signalling pathways and the influence of photobiomodulation on cellular signalling proteins in diabetic wound healing
The induction of a cells destiny is a tightly controlled process that is regulated through communication between the matrix and cell signalling...
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Akkermansia muciniphila and its membrane protein ameliorates intestinal inflammatory stress and promotes epithelial wound healing via CREBH and miR-143/145
BackgroundThe intestinal epithelial barrier is the interface for interaction between gut microbiota and host metabolic systems. Akkermansia...
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Expression characteristics and their functional role of IGFBP gene family in pan-cancer
BackgroundInsulin-like growth factor binding proteins (IGFBPs) are critical regulators of the biological activities of insulin-like growth factors....
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Human adaptation to high altitude: a review of convergence between genomic and proteomic signatures
Both genomics- and proteomics-based investigations have identified several essential genes, proteins, and pathways that may facilitate human adaptive...
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Predictors of muscle hypertrophy responsiveness to electrically evoked resistance training after spinal cord injury
The purpose of the study was to identify potential predictors of muscle hypertrophy responsiveness following neuromuscular electrical stimulation...
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S100A6: molecular function and biomarker role
S100A6 (also called calcyclin) is a Ca 2+ -binding protein that belongs to the S100 protein family. S100A6 has many functions related to the...
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Human umbilical cord mesenchymal stem cells attenuate diabetic nephropathy through the IGF1R-CHK2-p53 signalling axis in male rats with type 2 diabetes mellitus
Diabetes mellitus (DM) is a disease syndrome characterized by chronic hyperglycaemia. A long-term high-glucose environment leads to reactive oxygen...
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Investigation of insulin-like growth factors/insulin-like growth factor binding proteins regulation in metabolic syndrome patients
ObjectiveThe insulin-like growth factors (IGFs) and their binding proteins (IGFBPs) are thought to play a significant role in metabolic pathways and...
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Blood and CSF Biomarkers in Autosomal Dominant Cerebellar Ataxias
A biomarker can be defined as a measurable indicator of the presence or severity of a disease state, often present before clinical signs are evident....
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Functional characterization of a novel p.Ser76Thr variant in IGFBP4 that associates with body mass index in American Indians
Insulin-like growth factor binding protein 4 (IGFBP4) is involved in adipogenesis, and IGFBP4 null mice have decreased body fat through decreased...
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Colorectal Cancer and Role of Biomarkers in Diagnosis, Prognostification and Personalized Treatment
Colorectal cancer (CRC) is the second leading cause of cancer-related mortality worldwide as per GLOBOCAN 2020. One out of five patients is diagnosed...
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Insulin-like growth factor 5 associates with human Aß plaques and promotes cognitive impairment
Risk factors such as dysregulation of Insulin-like growth factor (IGF) signaling have been linked to Alzheimer’s disease. Here we show that...
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The role of pregnancy associated plasma protein-A in triple negative breast cancer: a promising target for achieving clinical benefits
Pregnancy associated plasma protein-A (PAPP-A) plays an integral role in breast cancer (BC), especially triple negative breast cancer (TNBC). This...
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Associations between circulating obesity-related biomarkers and prognosis in female breast cancer survivors: a systematic review of observational data in women enrolled in lifestyle intervention trials
Obesity plays an important role in the development and progression of breast cancer via various oncogenic pathways. However, the biological...
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Relationship of circulating insulin-like growth factor-I and binding proteins 1–7 with mammographic density among women undergoing image-guided diagnostic breast biopsy
BackgroundMammographic density (MD) is a strong breast cancer risk factor that reflects fibroglandular and adipose tissue composition, but its...
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Intranasal administration of induced pluripotent stem cell-derived cortical neural stem cell-secretome as a treatment option for Alzheimer’s disease
BackgroundAlzheimer’s disease (AD) is the most common neurodegenerative disorder in the elderly, resulting in gradual destruction of cognitive...
