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Detecting Hypoxia-Inducible Factor Levels and Activity
The hypoxia-inducible transcription factors HIF-1 and HIF-2 regulate the response to hypoxia. Both proteins are dimers of an alpha subunit and a...
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Hypoxia-Inducible Factor Activation in High-Altitude Stress
As altitude increases, the tropospheric barometric pressure falls. A proportionate fall in the partial pressure of oxygen happens along with a...
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Hypoxia-inducible factor 1α modulates interstitial pneumonia-mediated lung cancer progression
BackgroundThe prognosis of patients with lung cancer accompanied by interstitial pneumonia is poorer than that of patients with lung cancer but...
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Hypoxia-inducible factor-driven glycolytic adaptations in host-microbe interactions
Mammalian cells utilize glucose as a primary carbon source to produce energy for most cellular functions. However, the bioenergetic homeostasis of...
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AXL is required for hypoxia-mediated hypoxia-inducible factor-1 alpha function in glioblastoma
Glioblastoma (GBM) is the most aggressive type of central nervous system tumor. Molecular targeting may be important when develo** efficient GBM...
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Prenatal Hypoxia Causes an Increase in the Content and Transcriptional Activity of the Hypoxia-Inducible Factor HIF1α in the Hippocampus of Adult and Aging Rats
Abstract —Using Western blotting, we conducted a study investigating the expression levels of the regulatory alpha subunit of hypoxia-inducible factor...
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Hypoxia-Inducible Factor 1α and Its Role in Lung Injury: Adaptive or Maladaptive
Hypoxia-inducible factors (HIFs) are transcription factors critical for the adaptive response to hypoxia. There is also an essential link between...
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The role of hypoxia-inducible factor 1α in hepatic lipid metabolism
AbstractChronic liver disease is a major public health problem with a high and increasing prevalence worldwide. In the progression of chronic liver...
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Targeting hypoxia-inducible factors: therapeutic opportunities and challenges
Hypoxia-inducible factors (HIFs) are highly conserved transcription factors that are crucial for adaptation of metazoans to limited oxygen...
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Hypoxia-inducible factor 3α1 increases epithelial-to-mesenchymal transition and iron uptake to drive colorectal cancer liver metastasis
Background/objectivesHypoxia-inducible factor (HIF)-3α1’s role in colorectal cancer (CRC) cells, especially its effects on epithelial-mesenchymal...
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Elucidating the role of hypoxia-inducible factor in rheumatoid arthritis
Rheumatoid arthritis (RA) is a chronic multifactorial disease, provocative, and degenerative autoimmune condition that impacts millions of...
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The role of hypoxia-inducible factor 1 alpha (HIF-1α) modulation in heavy metal toxicity
Hypoxia-inducible factor 1 (HIF-1) is an oxygen-sensing transcriptional regulator orchestrating a complex of adaptive cellular responses to hypoxia....
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Involvement of Protein Kinase R in Double-Stranded RNA-Induced Proteasomal Degradation of Hypoxia Inducible Factor-1α
Hypoxia inducible factor-1α (HIF-1α) is a crucial therapeutic target in various diseases, including cancer and fibrosis. We previously demonstrated...
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Modulation of hypoxia-inducible factor-1 signaling pathways in cancer angiogenesis, invasion, and metastasis by natural compounds: a comprehensive and critical review
Tumor cells employ multiple signaling mediators to escape the hypoxic condition and trigger angiogenesis and metastasis. As a critical orchestrate of...
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Multiplex Immunofluorescence Staining Protocol for the Dual Imaging of Hypoxia-Inducible Factors 1 and 2 on Formalin-Fixed Paraffin-Embedded Samples
Hypoxia is a common condition in rapidly proliferating tumors and occurs when oxygen delivery to the tissue is scarce. It is a prevalent feature in...
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YWHAH Genetic Variants are Associated with Increased Hypoxia Inducible Factor-1α/Vascular Endothelial Growth Factor in Egyptian Rheumatoid Arthritis Patients
The 14–3-3 Eta (14–3-3 η) biomarker platform is a relatively recent discovery with the potential to significantly address the diagnosis and prognosis...
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Pericyte, but not astrocyte, hypoxia inducible factor-1 (HIF-1) drives hypoxia-induced vascular permeability in vivo
BackgroundWays to prevent disease-induced vascular modifications that accelerate brain damage remain largely elusive. Improved understanding of...
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The sensitivity of acute myeloid leukemia cells to cytarabine is increased by suppressing the expression of Heme oxygenase-1 and hypoxia-inducible factor 1-alpha
BackgroundAcute myeloid leukemia (AML), a malignancy Often resistant to common chemotherapy regimens (Cytarabine (Ara-c) + Daunorubicin (DNR)), is...
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Hypoxia-Inducible Factor-1α Protects Against Intervertebral Disc Degeneration Through Antagonizing Mitochondrial Oxidative Stress
Intervertebral disc degeneration (IVDD) demonstrates a gradually increased incidence and has developed into a major health problem worldwide. The...
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Transforming growth factor-β1 decreases erythropoietin production through repressing hypoxia-inducible factor 2α in erythropoietin-producing cells
BackgroundRenal erythropoietin (EPO)-producing (REP) cells produce EPO through hypoxia-inducible factor (HIF) 2α-activated gene transcription....
