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Tyrosine kinase inhibitor–induced hypothyroidism: mechanism and clinical implications
IntroductionSince the first experimentally proven tyrosine kinase inhibitor (TKI) imatinib was introduced in the clinical setting, TKIs have...
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Effects of levothyroxine replacement therapy on insulin resistance in patients with untreated primary hypothyroidism
ObjectivesThis study investigated the effects of levothyroxine replacement therapy on insulin resistance, lipid profile, and thyroid function in...
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Deciphering the roles of triiodothyronine (T3) and thyroid-stimulating hormone (TSH) on cardiac electrical remodeling in clinical and experimental hypothyroidism
Hypothyroidism is the most frequent endocrine pathology. Although clinical or overt hypothyroidism has been traditionally associated to low T3 / T4...
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Hypothyroidism Modeling in Wistar Rats: Comparison of Two Surgical Methods
In this study we present 2 surgical models of hypothyroidism in male Wistar rats ( n =80) based on total thyroidectomy. Animals weighing 180-200 g were...
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Primary Hypothyroidism and Alzheimer’s Disease: A Tale of Two
Hypothyroidism (HPT) HPT could be a risk factor for the development and progression of Alzheimer’s disease (AD). In addition, progressive...
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Melissa officinalis extract suppresses endoplasmic reticulum stress-induced apoptosis in the brain of hypothyroidism-induced rats exposed to γ-radiation
The purpose of this study was to demonstrate the neuroprotective effect of Melissa officinalis extract (MEE) against brain damage associated with...
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Human amnion-derived mesenchymal stem cells improve subclinical hypothyroidism by immunocompetence mediating apoptosis inhibition on thyroid cells in aged mice
Subclinical hypothyroidism (SCH) affects 10% of the global population, which is most prevalent in women and the elderly. However, it remains...
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Analysis of correlative risk factors for radiation-induced hypothyroidism in head and neck tumors
ObjectiveThe aim of the study is to identify clinical and dosimetric factors that could predict the risk of radiation-induced hypothyroidism(RIHT) in...
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Primary hypothyroidism and chronotypes in adult women
ObjectiveAbnormal thyroid function may disrupt sleep architecture. We aimed to determine the frequency of various chronotypes in women with...
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Ameliorative effects of thiamin on learning behavior and memory dysfunction in a rat model of hypothyroidism: implication of oxidative stress and acetylcholinesterase
Hypothyroidism causes learning and memory impairment. Considering the neuroprotective properties of thiamine (Vitamin B1), this study was conducted...
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Predictors of radiation-induced hypothyroidism in nasopharyngeal carcinoma survivors after intensity-modulated radiotherapy
BackgroundThe aim of the study is to identify clinical and dosimetric factors that could predict the risk of hypothyroidism in nasopharyngeal...
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Thyroid V40 is a good predictor for subclinical hypothyroidism in patients with nasopharyngeal carcinoma after intensity modulated radiation therapy: a randomized clinical trial
BackgroundHypothyroidism (HT) and subclinical HT after radiotherapy is frequent in nasopharyngeal carcinoma (NPC) patients, results in negative...
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Radioactive Iodine-induced hypothyroidism interferes with the maturation of reproductive organs during puberty in immature female rats
Animal and human studies suggest that thyroid hormone may have critical roles in the development of the ovary. For example, thyroid deficiency...
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The effect of the polycystic ovary syndrome and hypothyroidism on the risk of fibrocystic breast changes: a meta-analysis
This meta-analysis aimed to determine the pooled association between polycystic ovary syndrome (PCOS), hypothyroidism, and fibrocystic breast...
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A Case Report of IPEX Syndrome with Neonatal Diabetes Mellitus and Congenital Hypothyroidism as the Initial Presentation, and a Systematic Review of neonatal IPEX
Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is a serious disorder, which may comprise diabetes, thyroid disease,...
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Genome‑wide profiling of DNA methylation and gene expression unravel the epigenetic landscape in diabetes-related hypothyroidism
BackgroundType 2 diabetes mellitus (T2DM) and hypothyroidism are two common endocrine diseases and the phenomenon that the prevalence of...
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Serotonin 2A receptor function and depression-like behavior in rats model of hypothyroidism
Hypothyroidism causes somatic, psychosocial and affective psychosis, including depression-like behaviors. In this study, (hypothyroidism group; HP...
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Incidence of hypothyroidism after treatment for breast cancer—a Danish matched cohort study
BackgroundBreast cancer survivors (BCS) may have increased risk of hypothyroidism, but risk according to treatment modality is unclear. We estimated...
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Maternal Subclinical Hypothyroidism in Rats Impairs Spatial Learning and Memory in Offspring by Disrupting Balance of the TrkA/p75NTR Signal Pathway
Maternal subclinical hypothyroidism (SCH) during pregnancy can adversely affect the neurodevelopment of the offspring. The balance of nerve growth...
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Does hypothyroidism increase the risk of breast cancer: evidence from a meta-analysis
PurposeAt present, the relationship between hypothyroidism and the risk of breast cancer is still inconclusive. This meta-analysis was used to...
