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Comparative pharmacokinetic investigation on crocetin in hyperlipidemia and normal rats after oral administration
Crocetin as one of the main components of saffron possesses a lot of pharmacological effects, especially the beneficial effects in the treatment of...
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Identification of Central Genes and Regulatory Pathways Associated with Hyperlipidemia in Rats
Hyperlipidemia is an independent risk factor for cardiovascular and cerebrovascular diseases. The transcriptomic data and the gene regulatory...
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Hyperlipidemia in tendon injury: chronicles of low-density lipoproteins
Hyperlipidemia impacts millions of people globally and has been the major risk factor for develo** atherosclerosis and cardiovascular disease....
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A novel small-molecule PCSK9 inhibitor E28362 ameliorates hyperlipidemia and atherosclerosis
Proprotein convertase subtilisin/kexin type 9 (PCSK9) binds to the epidermal growth factor precursor homologous domain A (EGF-A) of low-density...
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A novel mouse model of familial combined hyperlipidemia and atherosclerosis
Within the context of residual cardiovascular risk in post-statin era, emerging evidence from epidemiologic and human genetic studies have...
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Pharmacodynamic Studies of Pravastatin Sodium Nanoemulsion Loaded Transdermal Patch for Treatment of Hyperlipidemia
Pravastatin sodium (PVS) is a hypolipidemic drug with poor oral bioavailability due to the first-pass effect. Therefore, this study aims to formulate...
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Integrative regulation of hLMR1 by dietary and genetic factors in nonalcoholic fatty liver disease and hyperlipidemia
Long non-coding RNA (lncRNA) genes represent a large class of transcripts that are widely expressed across species. As most human lncRNAs are...
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Hypolipidemic effect of ethanol extract from Chimonanthus nitens Oliv. leaves in hyperlipidemia rats via activation of the leptin/JAK2/STAT3 pathway
BackgroundThis study aims to explore the protective role of ethanol extract from Chimonanthus nitens Oliv. leaf (COE) in hyperlipidemia via the...
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Role of Hypertension and Hyperlipidemia in the Pathogenesis of Dementia
Dementia is not a single ailment, but a term that describes symptoms of impairment in memory, communication, and thinking, which occurs mainly in the...
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Asprosin Exacerbates Endothelium Inflammation Induced by Hyperlipidemia Through Activating IKKβ-NF-κBp65 Pathway
Vascular endothelium dysfunction caused by endothelium inflammation is a trigger of numerous cardiovascular diseases. Vascular endothelium...
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A common variant in 11q23.3 associated with hyperlipidemia is mediated by the binding and regulation of GATA4
Large-scale genome-wide associations comprising multiple studies have identified hundreds of genetic loci commonly associated with...
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Genetics of Familial Combined Hyperlipidemia (FCHL) Disorder: An Update
Familial combined hyperlipidemia (FCHL) is one of the most common familial lipoprotein disorders of the lipoproteins, with a prevalence of 0.5% to 2%...
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Integrated lipidomics and network pharmacology analysis to reveal the mechanisms of berberine in the treatment of hyperlipidemia
BackgroundBerberine (BBR), an isoquinoline alkaloid isolated from Rhizoma Coptis, is widely used in the treatment of hyperlipidemia (HLP) in China....
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Observation of Skin Color Change by Carotenosis in Hyperlipidemia Patient
PurposeIn this study, we focus on the relationship between carotenosis and hyperlipidemia. Because carotenoids are lipophilic, they are more soluble...
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Exercise and Hyperlipidemia
Hyperlipidemia is one of the common pathological conditions of human, which occurs due to lipid metabolism disorder in the human body, resulting in...
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Prevalence and associated factors of uncontrolled hyperlipidemia among Thai patients with diabetes and clinical atherosclerotic cardiovascular diseases: a cross-sectional study
ObjectivesThe research aimed to determine the prevalence and associated factors of uncontrolled hyperlipidemia among Thai patients with the disease...
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Autophagy, Hyperlipidemia, and Atherosclerosis
Autophagy is an evolutionarily conserved process in eukaryotes that processes the turnover of intracellular substances. Atherosclerosis is a disease...
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Role of Synbiotics in Metabolic Disorders
Metabolic disorders have reached epidemic proportions worldwide, making them one of the twenty-first century’s most serious public health issues. The...
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High fat diet induces brain injury and neuronal apoptosis via down-regulating 3-β hydroxycholesterol 24 reductase (DHCR24)
Hyperlipidemia (HLP) is one of the risk factors for memory impairment and cognitive impairment. However, its pathological molecular mechanism...
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Effects of risk factors on the development and mortality of early- and late-onset dementia: an 11-year longitudinal nationwide population-based cohort study in South Korea
BackgroundEarly-onset dementia (EOD, onset age < 65) and late-onset dementia (LOD, onset age ≥ 65) exhibit distinct features. Understanding the risk...
