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Encapsulation and release of hydrocortisone from proliposomes govern vaginal delivery
Topical preparations of hydrocortisone can be used for the anti-inflammatory treatment of the female genital area. Although the drug is a...
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The effects of hydrocortisone and yohimbine on human behavior in approach-avoidance conflicts
RationaleBalancing approach of positive and avoidance of negative stimuli is essential when faced with approach-avoidance conflicts, e.g., situations...
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Thiram, an inhibitor of 11ß-hydroxysteroid dehydrogenase type 2, enhances the inhibitory effects of hydrocortisone in the treatment of osteosarcoma through Wnt/β-catenin pathway
BackgroundThe anti-osteosarcoma effects of hydrocortisone and thiram, an inhibitor of type 2 11ß-hydroxysteroid dehydrogenase (11HSD2), have not been...
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Effect of elevated temperature and hydrocortisone addition on the proliferation of fibroblasts
Hyperthermia along with hydrocortisone (HC) are proven teratogens that can negatively influence embryo development during early pregnancy....
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Fabrication of 3D-Printed Hydrocortisone Triple Pulsatile Tablet Using Fused Deposition Modelling Technology
Hydrocortisone (HC) is the optimal drug for adolescents diagnosed with congenital adrenal hyperplasia (CAH). Because traditional dosage regimens HC...
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Chronotherapy based on modified-release hydrocortisone to restore the physiological cortisol diurnal rhythm
In this inspirational note, we describe the development of an endocrine chronotherapy to restore the physiological rhythm of the essential adrenal...
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Sex-specific effects of low-dose hydrocortisone on threat detection in HIV
One sex differences in the perception of emotion is that females, particularly those with high anxiety, often show heightened identification of...
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A high leukocyte count and administration of hydrocortisone hamper PCR-based diagnostics for bloodstream infections
Bloodstream infections (BSIs) require an accurate and fast identification of causative pathogens. Molecular diagnostics, in particular polymerase...
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Topical and transdermal delivery with diseased human skin: passive and iontophoretic delivery of hydrocortisone into psoriatic and eczematous skin
Psoriasis and atopic dermatitis (eczema) are both common immune-mediated inflammatory skin diseases associated with changes in skin’s stratum corneum...
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A Biopredictive
In Vitro Approach for Assessing Compatibility of a Novel Pediatric Hydrocortisone Drug Product within Common Pediatric Dosing VehiclesPurposeThe objective of the present work was to screen whether a novel pediatric hydrocortisone granule formulation can be co-administered with...
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Classification of Potent and Weak Penetration Enhancers Using Multiple Feature Selection Methods and Machine Learning Models
PurposeChemical penetration enhancers (CPEs) are important in transdermal drug delivery (TDDD) formulations because they assist drugs in moving...
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Physicochemical compatibility of caffeine citrate and caffeine base injections with parenteral medications used in neonatal intensive care settings
PurposeTo investigate the physicochemical compatibility of caffeine citrate and caffeine base injections with 43 secondary intravenous (IV) drugs...
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Development and Evaluation of Combined Effect Buccal Films for Treatment of Oral Candidiasis
Buccal film formulations, including antifungal nystatin, anti-inflammatory agent hydrocortisone acetate, and local anesthetic lidocaine hydrochloride...
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A comparative study of passive drug diffusion through human skin via intercellular and sweat duct route: effect of aging
A method of drug delivery that could provide control over medicine reaching the bloodstream for systemic circulation would be of immense importance....
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Pembrolizumab-induced secondary adrenal insufficiency due to adrenocorticotrophic hormone deficiency in a patient with non-small-cell lung carcinoma: a case report
BackgroundPembrolizumab can cause immune-related adverse events such as adrenal insufficiency (AI). However, there is no consensus regarding...
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Non-assisted Reproductive Technology (ART) Treatments for Infertile Women with Anti-sperm Antibody (ASA)
Before the introduction of in vitro fertilization and embryo transfer (IVF-ET), there are essentially two strategies for the treatments of infertile...
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Topical phenytoin administration accelerates the healing of acetic acid-induced colitis in rats: evaluation of transforming growth factor-beta, platelet-derived growth factor, and vascular endothelial growth factor
Ulcerative colitis (UC), limited to the colon’s innermost lining, has become a global health problem. Immunomodulatory and monoclonal antibodies are...
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Analysis of Nanoparticles’ Effects on Drug-Induced Psoriasis
Psoriasis, an auto-inflammatory disorder, has major manifestations in the skin but can affect other organs. Currently, this condition has no cure,...
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Comparison of the effects of pachymic acid, moronic acid and hydrocortisone on the polysome loading of RNAs in lipopolysaccharide-treated THP-1 macrophages
We have proposed that analysis of ribosome-loaded mRNAs (i.e., the translatome) is useful for elucidation of pharmacological effects of...
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Comparative potential of hydrocortisone, deoxycorticosterone and dexamethasone in the prevention of cataract: an in silico and in vitro study
Cataract is visual impairment which arises due to disturbance of lens transparency due to aggregation of the protein. Currently, surgery is the only...
