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Patients with restless legs syndrome exhibit reduced serum colony-stimulating factor-1, humanin-like 3 and 10 levels
ObjectiveThe main pathophysiological mechanisms in restless legs syndrome (RLS) are known as genetic predisposition, brain iron deficiency, and...
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A novel beneficial role of humanin on intestinal apoptosis and dysmotility in a rat model of ischemia reperfusion injury
A prevalent clinical problem including sepsis, shock, necrotizing enterocolitis, and mesenteric thrombosis is intestinal ischemia/reperfusion (I/R)...
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S14G-humanin (HNG) protects retinal endothelial cells from UV-B-induced NLRP3 inflammation activation through inhibiting Egr-1
UV-B stimulation can induce retinopathy, whose pathogenesis is currently unclear. UV-B mediated inflammation in retinal endothelial cells is reported...
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Neuron-derived extracellular vesicles in blood reveal effects of exercise in Alzheimer’s disease
BackgroundNeuron-derived extracellular vesicles (NDEVs) in blood may be used to derive biomarkers for the effects of exercise in Alzheimer’s disease...
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Assay Development and Measurement of the Aging Biomarker Humanin
Biomarkers that reflect aging could be used to target age-related diseases with precision and monitor treatment efficacy. One such biomarker is...
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Genetic variants in humanin nuclear isoform gene regions show no association with coronary artery disease
ObjectiveCoronary artery disease contributes to noncommunicable disease deaths worldwide. In order to make preventive methods more accurate, we need...
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A possible role for mitochondrial-derived peptides humanin and MOTS-c in patients with Q fever fatigue syndrome and chronic fatigue syndrome
BackgroundQ fever fatigue syndrome (QFS) is a well-documented state of prolonged fatigue following around 20% of acute Q fever infections. It has...
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Socialized mitochondria: mitonuclear crosstalk in stress
Traditionally, mitochondria are considered sites of energy production. However, recent studies have suggested that mitochondria are signaling...
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Micropeptides: origins, identification, and potential role in metabolism-related diseases
With the development of modern sequencing techniques and bioinformatics, genomes that were once thought to be noncoding have been found to encode...
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Mitochondria-derived peptide MOTS-c: effects and mechanisms related to stress, metabolism and aging
MOTS-c is a peptide encoded by the short open reading frame of the mitochondrial 12S rRNA gene. It is significantly expressed in response to stress...
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Chaperone-Mediated Autophagy in Brain Injury: A Double-Edged Sword with Therapeutic Potentials
Autophagy is an intracellular recycling process that maintains cellular homeostasis by degrading excess or defective macromolecules and organelles....
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Mitochondria, immunosenescence and inflammaging: a role for mitokines?
A global resha** of the immune responses occurs with ageing, indicated as immunosenescence, where mitochondria and mitochondrial metabolism play an...
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MOTS-c regulates pancreatic alpha and beta cell functions in vitro
The aim of this study is to determine the influence of the mitochondrial open-reading-frame of the twelve S rRNA-c (MOTS-c) peptide on pancreatic...
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The mitochondrial transcriptome of the anglerfish Lophius piscatorius
ObjectiveAnalyze key features of the anglerfish Lophius piscatorius mitochondrial transcriptome based on high-throughput total RNA sequencing.
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Single-Cell Transcriptional Profiling and Gene Regulatory Network Modeling in Tg2576 Mice Reveal Gender-Dependent Molecular Features Preceding Alzheimer-Like Pathologies
Alzheimer’s disease (AD) onset and progression is influenced by a complex interplay of several environmental and genetic factors, one of them gender....
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The Critical Role of Erythrolysis and Microglia/Macrophages in Clot Resolution After Intracerebral Hemorrhage: A Review of the Mechanisms and Potential Therapeutic Targets
Intracerebral hemorrhage (ICH) is a common cerebrovascular disorder with high morbidity and mortality. Secondary brain injury after ICH, which is...
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Mitochondrial peptides—appropriate options for therapeutic exploitation
Besides their well-known function in cellular bioenergetics, the role of mitochondria in signaling regulation of cells homeostasis and survival has...
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Lysosomal lipid alterations caused by glucocerebrosidase deficiency promote lysosomal dysfunction, chaperone-mediated-autophagy deficiency, and alpha-synuclein pathology
Mutations in the GBA gene that encodes the lysosomal enzyme β-glucocerebrosidase (GCase) are a major genetic risk factor for Parkinson’s disease...
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Baculovirus-based gene silencing of Humanin for the treatment of pituitary tumors
Pituitary tumors are the most common primary intracranial neoplasms. Humanin (HN) and Rattin (HNr), a rat homolog of HN, are short peptides with a...
