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Global effects of identity and aging on the human sperm methylome
BackgroundAs the average age of fatherhood increases worldwide, so too does the need for understanding effects of aging in male germline cells....
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Low acrosin activity is associated with decreased Spam1/acrosin expression and GSH deficiency-caused premature acrosome release of human sperm cells
Low acrosin activity (LAA) is associated with sperm function anomaly and poor outcomes of in vitro fertilization. In this study, we confirm that 993...
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Quantitative proteomics of sperm tail in asthenozoospermic patients: exploring the molecular pathways affecting sperm motility
Asthenozoospermia, characterized by low sperm motility, is one of the most common causes of male infertility. While many intrinsic and extrinsic...
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Sperm epigenetics and male infertility: unraveling the molecular puzzle
BackgroundThe prevalence of infertility among couples is estimated to range from 8 to 12%. A paradigm shift has occurred in understanding of...
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Influence of Extracellular Vesicles of the Follicular Fluid on Morphofunctional Characteristics of Human Sperm
We studied the effect of extracellular vesicles of the follicular fluid on morphofunctional characteristics of human spermatozoa using CASA...
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Unraveling the Molecular Impact of Sperm DNA Damage on Human Reproduction
Semen analysis is the cornerstone in the investigation of fertility status of male partner. However, more advanced tests have emerged including the...
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Methyl β-Cyclodextrin-sperm-mediated gene editing (MBCD-SMGE): a simple and efficient method for targeted mutant mouse production
BackgroundGenerating targeted mutant mice is a crucial technology in biomedical research. This study focuses on optimizing the CRISPR/Cas9 system...
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Small noncoding RNAs and sperm nuclear basic proteins reflect the environmental impact on germ cells
BackgroundMolecular techniques can complement conventional spermiogram analyses to provide new information on the fertilizing potential of...
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Analysis of Notch1 signaling in mammalian sperm development
ObjectiveA mammalian Delta-Notch signaling component, Notch1 , has been suggested for its expression during the normal sperm development although its...
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Protective effects of benfotiamine on cyfluthrin-induced testicular damage and sperm characteristics during the prepubertal period
Cyfluthrin, a widely used synthetic pyrethroid insecticide, poses potential risks to both human health and the environment due to its extensive...
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Proteomics study reveals the molecular mechanisms underlying cryotolerance induced by mild sublethal stress in human sperm
The preconditioning of human sperm with sublethal nitrosative stress before cryopreservation can potentially improve the thawed sperm quality....
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Does COVID-19 affect sperm quality in males? the answer may be yes, but only temporarily
BackgroundThe Corona Virus Disease 2019 (COVID-19) pandemic has raised concerns regarding its potential impact on male reproductive health. However,...
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A Preliminary Study on the Evaluation of Human Sperm Head Morphology with a Domestic Digital Holographic Image System
The head of sperm was imaged with domestic digital holographic microscopy (DHM), and then the quantitative three-dimensional size information of...
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Antioxidant Genes Variants and Their Association with Sperm DNA Fragmentation
Semen possesses a variety of antioxidant defense mechanisms which protect sperm DNA from the damaging effects of oxidative stress. Correlation...
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ZIF-8 Nanoparticle: A Valuable Tool for Improving Gene Delivery in Sperm-Mediated Gene Transfer
Metal–organic frameworks (MOFs) are porous materials with unique characteristics that make them well-suited for drug delivery and gene therapy...
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Basic Phenoty** of Male Fertility from 2019 to 2020 at the Human Sperm Bank of Fudan University
The aim of this cross-sectional survey was to analyze the semen parameters of volunteers from the Human Sperm Bank of Fudan University, as well as...
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Production of Anti-sperm Antibody (ASA) in Women
The factors that affect production of anti-sperm antibodies (ASAs) in some women are not fully understood. Moreover, the reasons why majority of...
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Steroid Hormones in Seminal Plasma: the Relationship with Sperm Quality
The purpose of this study was to find out whether the seminal testosterone and/or estradiol levels could serve as prognostic criteria for normal...
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Sperm DNA methylome abnormalities occur both pre- and post-treatment in men with Hodgkin disease and testicular cancer
BackgroundCombination chemotherapy has contributed to increased survival from Hodgkin disease (HD) and testicular cancer (TC). However, questions...
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Improved Sperm Function in Human Sperm Subpopulations: A Model for Studying Subfertility
With many cases of male infertility being idiopathic or unknown, the necessity for in-depth functional and structural sperm analysis beyond routine...