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Characteristics and mechanisms of latency-reversing agents in the activation of the human immunodeficiency virus 1 reservoir
The "Shock and Kill" method is being considered as a potential treatment for eradicating HIV-1 and achieving a functional cure for acquired...
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Epstein-Barr virus variation in people living with human immunodeficiency virus in southeastern China
BackgroundPatients infected with HIV are at high risk of develo** Epstein-Barr Virus (EBV)-related diseases. The genotype and viral biological...
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The envelope proteins from SARS-CoV-2 and SARS-CoV potently reduce the infectivity of human immunodeficiency virus type 1 (HIV-1)
BackgroundViroporins are virally encoded ion channels involved in virus assembly and release. Human immunodeficiency virus type 1 (HIV-1) and...
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Association of TREX1 polymorphism with disease progression in human immunodeficiency virus type-1 (HIV-1) infected patients
The time interval between HIV-1 infection and AIDS development is not the same in all patients and depends largely on the genetic background of the...
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HIV
Acquired immunodeficiency syndrome (AIDS) is a life-threatening chronic condition caused by the human immunodeficiency virus (HIV). HIV infection...
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Human Immunodeficiency Virus as a Risk Factor for Cardiovascular Disease
The developments in HIV treatments have increased the life expectancy of people living with HIV (PLWH), a situation that makes cardiovascular disease...
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Delivering genes with human immunodeficiency virus-derived vehicles: still state-of-the-art after 25 years
Viruses are naturally endowed with the capacity to transfer genetic material between cells. Following early skepticism, engineered viruses have been...
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Predictors of hippocampal tauopathy in people with and at risk for human immunodeficiency virus infection
Combination antiretroviral therapy (cART) has extended lifespans of people living with HIV (PWH), increasing both the risk for age-related...
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Exploring the biological function of immune cell-related genes in human immunodeficiency virus (HIV)-1 infection based on weighted gene co-expression network analysis (WGCNA)
BackgroundAcquired immunodeficiency syndrome (AIDS) is a chronic infectious disease characterized by consistent immune dysfunction. The objective of...
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Prevalence of genital high-risk human papillomavirus infections and associated factors among women living with human immunodeficiency virus in Uganda
BackgroundWomen living with HIV are at risk for cervical dysplasia and cancer worldwide. In 2015, the World Health Organization (WHO) recommended...
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Advances in HIV therapeutics and cure strategies: findings obtained through non-human primate studies
Human immunodeficiency virus (HIV), the main contributor of the ongoing AIDS epidemic, remains one of the most challenging and complex viruses to...
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Molecular identification and genetic characteristics of Cryptosporidium spp., Giardia duodenalis, and Enterocytozoon bieneusi in human immunodeficiency virus/acquired immunodeficiency syndrome patients in Shanghai, China
BackgroundOpportunistic infections are a ubiquitous complication in human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS)...
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Neuroinflammation driven by human immunodeficiency virus-1 (HIV-1) directs the expression of long noncoding RNA RP11-677M14.2 resulting in dysregulation of neurogranin in vivo and in vitro
Neuroinflammation and synaptodendritic damage represent the pathological hallmarks of HIV-1 associated cognitive disorders (HAND). The post-synaptic...
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Anti-human immunodeficiency virus-1 activity of MoMo30 protein isolated from the traditional African medicinal plant Momordica balsamina
BackgroundPlants are used in traditional healing practices of many cultures worldwide. Momordica balsamina is a plant commonly used by traditional...
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Immunodeficiency Diseases
Immunodeficiency disorders are conditions where the defence mechanism of the body is impaired. They show enhanced susceptibility to infection with...
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Structural Insights to Human Immunodeficiency Virus (HIV-1) Targets and Their Inhibition
Human immunodeficiency virus (HIV) is a deadly virus that attacks the body’s immune system, subsequently leading to AIDS (acquired immunodeficiency...
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New Antiretroviral Agents for HIV Infection
The development of antiretroviral drugs for treatment of human immunodeficiency virus (HIV) infection is the most remarkable achievement in medical...
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Highly mutated monoclonal antibody 3F2 targets a conformational and strain-restricted epitope in human immunodeficiency virus gp41 with significant antibody-dependent cell cytotoxicity
Identifying epitope targets by studying the native antibody (Ab) response can identify potential novel vaccine constructs. Studies suggest that...
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Biodistribution and immunity of adenovirus 5/35 and modified vaccinia Ankara vector vaccines against human immunodeficiency virus 1 clade C
Previously, we developed a chimeric adenovirus type 5 with type 35 fiber (Ad5/35), which has high tropism to dendritic cells and low hepatoxicity....
