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Hsa_circ_0031891 targets miR-579-3p to enhance HMGB1 expression and regulate PDGF-BB-induced human aortic vascular smooth muscle cell proliferation, migration, and dedifferentiation
Atherosclerosis (AS) is an underlying cause of the majority of coronary artery disease (CAD), in which proliferation, migration, and...
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The multifunctional protein HMGB1: 50 years of discovery
Fifty years since the initial discovery of HMGB1 in 1973 as a structural protein of chromatin, HMGB1 is now known to regulate diverse biological...
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HMGB1: A New Target for Ischemic Stroke and Hemorrhagic Transformation
Stroke in China is distinguished by its high rates of morbidity, recurrence, disability, and mortality. The ultra-early administration of rtPA is...
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High Mobility Group Box Protein (HMGB1): A Potential Therapeutic Target for Diabetic Encephalopathy
HMGB (high mobility group B) is one of the ubiquitous non-histone nuclear protein superfamilies that make up the HMG (high mobility group) protein...
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HMGB1 and Toll-like receptors: potential therapeutic targets in autoimmune diseases
HMGB1, a nucleoprotein, is expressed in almost all eukaryotic cells. During cell activation and cell death, HMGB1 can function as an alarm protein...
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The Association of HMGB1 and RAGE Gene Polymorphisms with IgA Vasculitis
High-mobility group box 1 (HMGB1) is a pleiotropic cytokine that propagates inflammation by its extracellular action of interacting with the receptor...
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SHARPIN contributes to sevoflurane-induced neonatal neurotoxicity through up-regulating HMGB1 to repress M2 like-macrophage polarization
Sevoflurane exposure can result in neurotoxicity especially among children, which remains an important complication after surgery. However, its...
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USP13 regulates HMGB1 stability and secretion through its deubiquitinase activity
BackgroundHigh mobility group box 1 (HMGB1) is a damage-associated molecular pattern (DAMP) molecule that plays a central role in innate immunity....
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Long Non-coding RNA SNHG1 Suppresses the Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells by Binding with HMGB1
Osteoporosis (OP) has a significant detrimental impact on the health of the elder. Long-term clinical effectiveness of current drugs used for OP...
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Autocrine regulation of tumor cell repopulation by Hsp70-HMGB1 alarmin complex
BackgroundCancer recurrence is regulated by a variety of factors, among which is the material of dying tumor cells; it is suggested that remaining...
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Mesenchymal Stem Cells Regulate Microglial Polarization via Inhibition of the HMGB1/TLR4 Signaling Pathway in Diabetic Retinopathy
Diabetic retinopathy (DR) is recognized as the most prevalent retinal degenerative disorder. Inflammatory response usually precedes microvascular...
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Preventive and therapeutic opportunities: targeting BAP1 and/or HMGB1 pathways to diminish the burden of mesothelioma
Mesothelioma is a cancer typically caused by asbestos. Mechanistically, asbestos carcinogenesis has been linked to the asbestos-induced release of...
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LncRNA KCNQ1OT1/miR-496/HMGB1 Signaling Axis Promotes Invasion and Migration of Non-small Cell Lung Cancer Cells
Enhanced invasion and migration of non-small cell lung cancer (NSCLC) cells is the major cause of metastasis and poor prognosis in NSCLC. This study...
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HMGB1 Mediates Inflammation-Induced DMT1 Increase and Dopaminergic Neurodegeneration in the Early Stage of Parkinsonism
Both neuroinflammation and iron accumulation play roles in the pathogenesis of Parkinson’s disease (PD). However, whether inflammation induces iron...
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GPR65 sensing tumor-derived lactate induces HMGB1 release from TAM via the cAMP/PKA/CREB pathway to promote glioma progression
BackgroundLactate has emerged as a critical regulator within the tumor microenvironment, including glioma. However, the precise mechanisms underlying...
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SIRT1-Mediated HMGB1 Deacetylation Suppresses Neutrophil Extracellular Traps Related to Blood–Brain Barrier Impairment After Cerebral Venous Thrombosis
Cerebral venous thrombosis (CVT) is a neurovascular disease with recently increasing incidence. Aseptic inflammatory responses play an important role...
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HMGB1 mediates synaptic loss and cognitive impairment in an animal model of sepsis-associated encephalopathy
BackgroundMicroglial activation-mediated neuroinflammation is one of the essential pathogenic mechanisms of sepsis-associated encephalopathy (SAE)....
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HMGB1/TLR4 signaling pathway enhances abdominal aortic aneurysm progression in mice by upregulating necroptosis
Objective and designThe age-associated increases in aseptic inflammation and necroptosis are closely related to the emergence of various...
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CircRNA-104718 promotes glioma malignancy through regulation of miR-218-5p/HMGB1 signalling pathway
Increasing number of studies have proven that circular RNAs (circRNAs) play a major role in the biological processes of many different cancers,...
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The mechanism of HMGB1 secretion and release
High mobility group box 1 (HMGB1) is a nonhistone nuclear protein that has multiple functions according to its subcellular location. In the nucleus,...
