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Genome-Wide Identification and Characterization of the Hsp70/110 Genes in Two Polychaetes, Capitella teleta and Owenia fusiformis
AbstractHsp70/110s are a subfamily of heat shock proteins that play crucial roles against different types of environmental stressors and pathogenic...
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A genome-wide screening of the 70 kDa heat shock protein (HSP70) genes in the rotifer Brachionus plicatilis sensu stricto with a characterization of two heat-inducible HSP70 genes
The 70 kDa heat shock proteins (HSP70s) and the constitutive members of the HSP70 family (heat shock cognates; HSC70s) play essential roles in...
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Transcriptome analysis of cervical cancer exosomes and detection of HPVE6*I transcripts in exosomal RNA
BackgroundExosomes play a key role in cell-to-cell communication and are integral component of the tumor microenvironment. Recent observations...
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Cryostress induces fragmentation and alters the abundance of sperm transcripts associated with fertilizing competence and reproductive processes in buffalo
The study aimed to assess the influence of cryostress on RNA integrity and functional significance in sperm fertilizing ability. The fresh and...
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Caspase-mediated cleavage of miRNA processing proteins Drosha, DGCR8, Dicer, and TRBP2 in heat-shocked cells and its inhibition by HSP70 overexpression
Cells respond to stress through adaptive mechanisms that limit cellular damage and prevent cell death. MicroRNAs act as regulators of stress...
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In Silico Analysis of HSP70 Gene Family in Bovine Genome
Heat shock proteins (HSPs), members of molecular chaperones families fulfill essential roles under normal conditions and provide protection and...
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Gene network analyses support subfunctionalization hypothesis for duplicated hsp70 genes in the Antarctic clam
A computationally predicted gene regulatory network (GRN), generated from mantle-specific gene expression profiles in the Antarctic clam Laternula...
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Acute and chronic lithium treatment increases Wnt/β-catenin transcripts in cortical and hippocampal tissue at therapeutic concentrations in mice
Lithium activates Wnt/β-catenin signaling leading to stabilization of free cytosolic β-catenin. The aim of the present study is to evaluate the in...
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Autophagy and Hsp70 activation alleviate oral epithelial cell death induced by food-derived hypertonicity
Stable intracellular and intercellular osmolarity is vital for all physiological processes. Although it is the first organ that receives food, the...
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Genetic profiling of Hsp70 gene in Murrah buffalo (Bubalus bubalis) under sub-tropical climate of India
This study was aimed to genetic profiling of heat shock protein 70 (Hsp70) gene in Murrah buffalo investigating 50 unrelated adult animals at...
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Heat increases full-length SMN splicing: promise for splice-augmenting therapies for SMA
Spinal muscular atrophy (SMA) is a debilitating neurodegenerative pediatric disease characterized by low levels of the survival motor protein (SMN)....
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Assessment of NLRP3 inflammasome activation in patients with chronic obstructive pulmonary disease before and after lung transplantation
The interplay between purinergic receptors as well as pattern recognition receptors like Toll-like receptors (TLRs) and NOD-, LRR-, and pyrin...
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Antarctic krill (Euphausia superba) in a warming ocean: thermotolerance and deciphering Hsp70 responses
The Antarctic krill, Euphausia superba , is a Southern Ocean endemic species of proven ecological importance to the region. In the context of...
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Variable heat shock response in Antarctic biofouling serpulid worms
The classical heat shock response (HSR) with up-regulation of hsp70 in response to warming is often absent in Antarctic marine species. Whilst in...
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Using Single-Molecule Fluorescence Microscopy to Uncover Neuronal Vulnerability to Protein Damage
Neurodegenerative disorders (NDs) are diverse age-related conditions also described as “conformational diseases.” The hallmark of NDs is the...
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Gene-expression profiling of individuals resilient to Alzheimer's disease reveals higher expression of genes related to metallothionein and mitochondrial processes and no changes in the unfolded protein response
Some individuals show a discrepancy between cognition and the amount of neuropathological changes characteristic for Alzheimer’s disease (AD). This...
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Retinal pigment epithelium degeneration caused by aggregation of PRPF31 and the role of HSP70 family of proteins
BackgroundMutations in pre-mRNA splicing factor PRPF31 can lead to retinitis pigmentosa (RP). Although the exact disease mechanism remains unknown,...
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The combination of hypoxia and high temperature affects heat shock, anaerobic metabolism, and pentose phosphate pathway key components responses in the white shrimp (Litopenaeus vannamei)
Due to global warming, world water bodies have higher temperatures and lower oxygen concentrations that affect aquatic species including the white...
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Differential expression of heat shock protein genes in Rhipicephalus sanguineus (Acari: Ixodidae) exposed to temperature and humidity variations
The brown dog tick ( Rhipicephalus sanguineus ), a well-recognized parasite that is an important vector of many pathogens, widely distributed in the...
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Heat Shock Protein 70 as a Sex-Skewed Regulator of α-Synucleinopathy
The role of molecular chaperones, such as heat shock protein 70 (Hsp70), is not typically studied as a function of biological sex, but by addressing...
