Search
Search Results
-
Vivaria housing conditions expose sex differences in brain oxidation, microglial activation, and immune system states in aged hAPOE4 mice
Apolipoprotein E ε4 allele (APOE4) is the predominant genetic risk factor for late-onset Alzheimer’s disease (AD). APOE4 mouse models have provided...
-
Mixing and Filtration
Mixing and filtration are crucial in the pharmaceutical industry. Poor mixing can result in product failure, while sterile filtration is the only...
-
A Mouse Model of Non-Alcoholic Steatohepatitis and Hepatocellular Carcinoma Induced by Western Diet and Carbon Tetrachloride
Non-alcoholic steatohepatitis (NASH) is a severe form of non-alcoholic fatty liver disease (NAFLD). Obesity is a known risk factor of NASH, which, in...
-
Retrotransposon activation during Drosophila metamorphosis conditions adult antiviral responses
Retrotransposons are one type of mobile genetic element that abundantly reside in the genomes of nearly all animals. Their uncontrolled activation is...
-
Aseptic Spray Drying Technology
This chapter is dedicated to aseptic spray drying technology. The reader will learn the key elements for the design and components for constructing...
-
Bi-allelic variants in human TCTE1/DRC5 cause asthenospermia and male infertility
Asthenozoospermia (AZS) is a common male infertility phenotype, accounting for 18% of infertile patients. The N-DRC (Nexin-dynein Regulatory Complex)...
-
GDNF gene therapy for alcohol use disorder in male non-human primates
Alcohol use disorder (AUD) exacts enormous personal, social and economic costs globally. Return to alcohol use in treatment-seeking patients with AUD...
-
In vivo metabolic imaging identifies lipid vulnerability in a preclinical model of Her2+/Neu breast cancer residual disease and recurrence
Recurrent cancer cells that evade therapy is a leading cause of death in breast cancer patients. This risk is high for women showing an...
-
Introduction to Toxicology
Toxicology (In Greek: Toxicon—poison; Logos—study) is an interdisciplinary field of biomedical sciences that is concerned with the study of adverse...
-
Opinions of key stakeholders on alternative interventions for malaria control and elimination in Tanzania
BackgroundMalaria control in Tanzania currently relies primarily on long-lasting insecticidal nets and indoor residual spraying, alongside effective...
-
Establishment of a Cell Culture Laboratory
The present chapter describes the design of a mammalian cell culture laboratory equipped for scientific research purposes. In addition to the main...
-
Overview of Current Downstream Processing for Modern Viral Vectors
In less than a decade, the applications of virus-based therapeutics have significantly expanded and are no longer restricted to ultra-rare diseases....
-
Zebrafish: an efficient vertebrate model for understanding role of gut microbiota
Gut microbiota plays a critical role in the maintenance of host health. As a low-cost and genetically tractable vertebrate model, zebrafish have been...
-
Convection Enhanced Delivery of Viral Vectors
Convection-enhanced delivery (CED) is a pressure-based approach of delivering agents, such as viral vectors, throughout large regions of tissue. CED...
-
Healthy infants harbor intestinal bacteria that protect against food allergy
There has been a striking generational increase in life-threatening food allergies in Westernized societies
1 ,2 . One hypothesis to explain this rising...
-
Eusociality
The basic concept of social inequality is the main driver of the present book since it implies some form of dominance, as much as the latter concept...
-
Genetic Improvements to the Sterile Insect Technique (SIT) for the Control of Mosquito Population
Mosquito-borne diseases are becoming a major health problem worldwide. At present, the principal method of controlling these diseases entirely...
-
Neural stem cell transplantation in patients with progressive multiple sclerosis: an open-label, phase 1 study
Innovative pro-regenerative treatment strategies for progressive multiple sclerosis (PMS), combining neuroprotection and immunomodulation, represent...
-
Three-dimensional (3D) liver cell models - a tool for bridging the gap between animal studies and clinical trials when screening liver accumulation and toxicity of nanobiomaterials
Despite the exciting properties and wide-reaching applications of nanobiomaterials (NBMs) in human health and medicine, their translation from bench...
-
Microbial regulation of intestinal motility provides resistance against helminth infection
Soil-transmitted helminths cause widespread disease, infecting ~1.5 billion people living within poverty-stricken regions of tropical and subtropical...
