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Generation of Protease Inhibitory Antibodies by Functional In Vivo Selection
Targeting dysregulated protease expression and/or abnormal substrate proteolysis, highly selective inhibition of pathogenic proteases by monoclonal...
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Novel high-yield potato protease inhibitor panels block a wide array of proteases involved in viral infection and crucial tissue damage
AbstractViruses critically rely on various proteases to ensure host cell entry and replication. In response to viral infection, the host will induce...
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Host-Directed Antiviral Therapy
Most of the antiviral drugs developed so far have been specifically designed to target particular pathogens and their unique viral pathways. However,...
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Elaborating the Role of Aspartyl Protease in Host Modulation and Invasion in Apicomplexan Parasites Plasmodium and Toxoplasma
The phylum Apicomplexa comprising the widest group of protozoan pathogens causes lethal diseases to humans and commercially crucial animals. Two...
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Aspartyl protease in the secretome of honey bee trypanosomatid parasite contributes to infection of bees
BackgroundThe exoproteome, which consists of both secreted proteins and those originating from cell surfaces and lysed cells, is a critical component...
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Dengue virus pathogenesis and host molecular machineries
Dengue viruses (DENV) are positive-stranded RNA viruses belonging to the Flaviviridae family. DENV is the causative agent of dengue, the most rapidly...
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miR-126a-5p inhibits H1N1-induced inflammation and matrix protease secretion in lung fibroblasts by targeting ADAMTS-4
Upregulation of ADAMTS-4 has been reported to have an important role in lung injury, and ADAMTS-4 expression is regulated by miR-126a-5p in abdominal...
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Exploring the viral protease inhibitor space driven by consensus scoring-based virtual screening
Dengue fever presents a major health concern, and the lack of an effective vaccine or definite therapeutic regimen has led the research community to...
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Molecular mechanisms involved in anosmia induced by SARS-CoV-2, with a focus on the transmembrane serine protease TMPRSS2
Since 2020, SARS-CoV-2 has caused a pandemic virus that has posed many challenges worldwide. Infection with this virus can result in a number of...
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The Characteristics of EV-A71-CV-A16 Infection and Interaction with a Host
Recently, the number of HFMD outbreaks in the Asia–Pacific region has been increasing every year. Relationship between EVs and activation of the host...
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Inhibitory effects of senkyuchachosan on SARS-CoV-2 papain-like protease activity in vitro
AbstractPapain-like protease (PLpro) enzyme plays a vital role in viral replication as it breaks down polyproteins and disrupts the host's immune...
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Applying Reverse Genetics to Study Measles Virus Interactions with the Host
The study of virus-host interactions is essential to achieve a comprehensive understanding of the viral replication process. The commonly used...
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Plant Peptides as Protease Inhibitors for Therapeutic and Agricultural Applications
Protease inhibitors from plants are proteinaceous molecules which form complex with proteases and inhibit their activity. Plants utilize these...
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TMPRSS4, a type II transmembrane serine protease, as a potential therapeutic target in cancer
Proteases are involved in almost all biological processes, implying their importance for both health and pathological conditions. Dysregulation of...
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Invalidation of dieckol and 1,2,3,4,6-pentagalloylglucose (PGG) as SARS-CoV-2 main protease inhibitors and the discovery of PGG as a papain-like protease inhibitor
The COVID-19 pandemic spurred a broad interest in antiviral drug discovery. The SARS-CoV-2 main protease (M pro ) and papain-like protease (PL pro ) are...
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Echinococcosis Immune Response, Immunopathogenesis and Immune Evasion from the Human Host
Echinococcosis is a worldwide parasitic disease with great harm and complicated immune mechanisms. Immunoprophylaxis is an ideal way to prevent...
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Aspergillus fumigatus secretes a protease(s) that displays in silico binding affinity towards the SARS-CoV-2 spike protein and mediates SARS-CoV-2 pseudovirion entry into HEK-293T cells
BackgroundThe novel coronavirus disease of 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus-2...
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Heterologous expression, purification, and proteomic characterization of a 37 kDa pupal gut serine protease from Bombyx mori in Escherichia coli
Recently, there has been a growing interest in exploring the potential of insect proteases for industrial applications, owing to their versatile...
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Plasmodium: Vertebrate Host
Plasmodium spp. infection remains as a major global health problem, being annually responsible for a large number of deaths. Disease eradication...
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African Swine Fever Virus Host–Pathogen Interactions
African swine fever virus is a complex double-stranded DNA virus that exhibits tropism for cells of the mononuclear phagocytic system. Virus...