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Lipid droplets in pathogen infection and host immunity
As the hub of cellular lipid metabolism, lipid droplets (LDs) have been linked to a variety of biological processes. During pathogen infection, the...
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An entomopathogenic fungus exploits its host humoral antibacterial immunity to minimize bacterial competition in the hemolymph
BackgroundThe insect hemolymph (blood-equivalent fluid), composed of a large number of hemocytes (blood cells) and a variety of soluble immune...
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Immunity
The term immunity is derived from the Latin word “immunis” (exempt), which originally referred to the protection from legal prosecution offered to... -
The molecular mechanism of SARS-CoV-2 evading host antiviral innate immunity
The newly identified Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has resulted in a global health emergency (COVID-19) because of its...
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Human Monkeypox Virus and Host Immunity: New Challenges in Diagnostics and Treatment Strategies
The monkeypox virus (MPXV), responsible for human disease, has historically been limited to the African countries, with only a few isolated instances... -
Clinical characteristics and host immunity responses of SARS-CoV-2 Omicron variant BA.2 with deletion of ORF7a, ORF7b and ORF8
BackgroundThe pathogenicity and virulence of the Omicron strain have weakened significantly pathogenesis of Omicron variants. Accumulating data...
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Immunity, Immunity, Immunity
Immunity is critical for survival from all infectious pathogens, including viruses. The three types of immunity (intrinsic, innate, and adaptive)... -
Regulation of Host Immunity by the Gut Microbiota
Constant exposure to diverse microorganisms has accompanied human evolution and continues to shape immunological development throughout life. In... -
Monkeypox: disease epidemiology, host immunity and clinical interventions
Monkeypox virus (MPXV), which causes disease in humans, has for many years been restricted to the African continent, with only a handful of sporadic...
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Echinococcosis Immune Response, Immunopathogenesis and Immune Evasion from the Human Host
Echinococcosis is a worldwide parasitic disease with great harm and complicated immune mechanisms. Immunoprophylaxis is an ideal way to prevent... -
Skin Microbiome and Host Immunity: Applications in Regenerative Cosmetics and Transdermal Drug Delivery
Recent advances in our understanding of the function of the skin and its microbiome have shown that there is a strong symbiotic relationship between... -
Host-Directed Antiviral Therapy
Most of the antiviral drugs developed so far have been specifically designed to target particular pathogens and their unique viral pathways. However,... -
SARS-CoV-2 Infection: Host Response, Immunity, and Therapeutic Targets
Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has resulted in a global...
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Nutritional Immunity and Fungal Pathogens: A New Role for Manganese
Purpose of ReviewCopper, zinc, iron, and manganese are essential micronutrients for all living organisms. Microbial pathogens must acquire these...
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Evasion and Suppression of Immunity
Pathogens must evade or suppress the host’s immune system to persist. Immune evasion refers to passive evasion and active suppression of immune... -
Tissue-specific immunity in helminth infections
A characteristic feature of host responses to helminth infections is the development of profound systemic and tissue-localised Type 2 immune...
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The role of plasmacytoid dendritic cells (pDCs) in immunity during viral infections and beyond
Type I and III interferons (IFNs) are essential for antiviral immunity and act through two different but complimentary pathways. First, IFNs activate...
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Innate Immunity and Inflammation
In this chapter, we will explain that the innate immune system has effector functions that allow a very early response to invading pathogens as well... -
Viruses, SUMO, and immunity: the interplay between viruses and the host SUMOylation system
The conjugation of small ubiquitin-like modifier (SUMO) proteins to substrates is a well-described post-translational modification that regulates...