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High-Throughput Multiplex Immunohistochemistry of Glioma Organoids
The invasive capacity and progression of glioblastoma cells and neoplastic cells in other are dependent on interactions with the surrounding tumor...
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Allele-level visualization of transcription and chromatin by high-throughput imaging
The spatial arrangement of the genome within the nucleus is a pivotal aspect of cellular organization and function with implications for gene...
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Optogenetic and High-Throughput Drug Discovery
Optogenetics, a technique based on natural or genetically engineered light-sensitive proteins, combines genetic manipulation and optics offering...
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High-Throughput Screening to Identify Modulators of Sarcospan
High-throughput screening enables the discovery of disease-modifying small molecules. Here, we describe the development of a scalable, cell-based...
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High-Throughput Screening Assays in Toxicology
This second edition volume expands on the previous edition by exploring the latest advancements in high throughput screening (HTS) in toxicity...
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Spatial multi-omics at subcellular resolution via high-throughput in situ pairwise sequencing
Technology for spatial multi-omics aids the discovery of new insights into cellular functions and disease mechanisms. Here we report the development...
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3D Hydrogel Cultures for High-Throughput Drug Discovery
Our increased understanding of how a cell’s microenvironment influences its behavior has fueled an interest in three-dimensional (3D) cell cultures...
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Systematic evaluation of high-throughput PBK modelling strategies for the prediction of intravenous and oral pharmacokinetics in humans
Physiologically based kinetic (PBK) modelling offers a mechanistic basis for predicting the pharmaco-/toxicokinetics of compounds and thereby...
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CSF N-Glycomics Using High-Throughput UPLC-ESI Techniques in Alzheimer’s Disease
In this chapter, we will present a high-throughput method applied in our laboratory for the structural elucidation of the cerebrospinal fluid (CSF)...
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Omic-Based Biomarkers Discovery in Alzheimer’s Disease: High-Throughput Approaches
The discovery of novel metabolomic, proteomic, lipidomic, and transcriptomic (mRNA and miRNA) biomarkers in serum, plasma, brain, and CSF is a...
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Omic-Based Biomarkers Discovery in Alzheimer’s Disease: High-Throughput Approaches
The discovery of novel metabolomic, proteomic, lipidomic, and transcriptomic (mRNA and miRNA) biomarkers in serum, plasma, brain, and CSF is a...
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Fluorescence-Based Peptidolytic Assay for High-Throughput Screening of MMP14 Inhibitors
The membrane-bound matrix metalloproteinase 14 (MMP14, also known as MT1-MMP) plays important roles in the remodeling of the extracellular matrix...
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High-Throughput SARS-CoV-2 Antiviral Testing Method Using the Celigo Image Cytometer
The COVID-19 pandemic has created a worldwide public health crisis that has since resulted in 6.8 million reported deaths. The pandemic prompted the...
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High-throughput biochemistry in RNA sequence space: predicting structure and function
RNAs are central to fundamental biological processes in all known organisms. The set of possible intramolecular interactions of RNA nucleotides...
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A high-throughput screening system for SARS-CoV-2 entry inhibition, syncytia formation and cell toxicity
BackgroundThe entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) into the host cell is mediated through the binding of the...
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High-throughput sequencing reveals Jatrorrhizine inhibits colorectal cancer growth by ferroptosis-related genes
BackgroundColorectal cancer is a malignant tumor that poses a serious threat to human health. The main objective of this study is to investigate the...
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Novel Multiplexed High Throughput Screening of Selective Inhibitors for Drug-Metabolizing Enzymes Using Human Hepatocytes
Selective chemical inhibitors are critical for reaction phenoty** to identify drug-metabolizing enzymes that are involved in the elimination of...
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A high-throughput neutralizing assay for antibodies and sera evaluation against Epstein-Barr virus
BackgroundEpstein-Barr virus (EBV) is a wide-spread human herpesvirus that is highly associated with infectious mononucleosis and several...
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Develop quantitative FRET (qFRET) technology as a high-throughput universal assay platform for basic quantitative biomedical and translational research and development
Protein–protein interactions and enzyme-catalyzed reactions are the fundamental processes in life, and the quantification and manipulation, kinetics...
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