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TCID50 Assay: A Simple Method to Determine Baculovirus Titer
There are many methods that can be used to determine the infectious titer of your baculovirus stock. The TCID50 method is a simple end-point dilution...
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Generation of High-Titer Defective HSV-1 Amplicon Vectors
Strategies for gene delivery into neurons, either to study the molecular biology of brain function or for gene therapy, must utilize vectors that...
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The clinical outcomes of high neutralizing antibodies titer convalescent plasma therapy in early developed severe COVID-19 patients; a case–control study
BackgroundCoronavirus disease 2019 (COVID-19) causes life-threatening pneumonia. Convalescent plasma therapy (CPT) is expected to be the effective...
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Screening of candidate genes associated with high titer production of oncolytic measles virus based on systems biology approach
The number of viral particles required for oncolytic activity of measles virus (MV) can be more than a million times greater than the reported amount...
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Despite low viral titer in saliva samples, Sanger-based SARS-CoV-2 spike gene sequencing is highly applicable for the variant identification
BackgroundThis study aimed to compare the performance of Sanger-based SARS-CoV-2 spike gene sequencing and Next Generation Sequencing (NGS)-based...
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Neutralization titer biomarker for antibody-mediated prevention of HIV-1 acquisition
The Antibody Mediated Prevention trials showed that the broadly neutralizing antibody (bnAb) VRC01 prevented acquisition of human immunodeficiency...
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Bimodal antibody-titer decline following BNT162b2 mRNA anti-SARS-CoV-2 vaccination in healthcare workers of the INT – IRCCS “Fondazione Pascale” Cancer Center (Naples, Italy)
BackgroundBoth SARS-CoV-2 mRNA-based vaccines [BNT162b2 (Pfizer-BioNTech) and mRNA-1273 (Moderna)] have shown high efficacy, with very modest side...
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Comparison of Titer and Signal to Noise (S/N) for Determination of Anti-drug Antibody Magnitude Using Clinical Data from an Industry Consortium
During biotherapeutic drug development, immunogenicity is evaluated by measuring anti-drug antibodies (ADAs). The presence and magnitude of ADA...
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Generation of a high yield vaccine backbone for influenza B virus in embryonated chicken eggs
Influenza B virus (IBV) strains are one of the components of seasonal influenza vaccines in both trivalent and quadrivalent formulations. The vast...
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Titer and distribution of little cherry virus 2 in Prunus avium
Little cherry virus 2 (LChV-2) is a causal agent of little cherry disease, which produces small, misshapen fruit with poor color and taste. As LChV-2...
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Simple prediction of COVID-19 convalescent plasma units with high levels of neutralization antibodies
BackgroundHyperimmune convalescent COVID-19 plasma (CCP) containing anti-SARS-CoV-2 neutralizing antibodies (NAbs) was proposed as a therapeutic...
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Serum soluble CD26/DPP4 titer variation is a potential prognostic biomarker in cancer therapy with a humanized anti-CD26 antibody
BackgroundThe phase I trial of the humanized anti-CD26 monoclonal antibody YS110 for CD26-expressing tumors was conducted recently. The present study...
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Generation of Complex Protein Structures by Coinfection with High-Quality Recombinant Baculovirus
The baculovirus expression vector system (BEVSbaculovirus expression vector system (BEVS))Baculovirus expression vector system (BEVS) is a powerful...
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Neonatal SARS-CoV-2 immunoglobulin G antibodies at delivery and their impact on COVID-19
ObjectiveTo assess neonatal SARS-CoV-2 anti-spike IgG antibody levels after maternal mRNA COVID-19 vaccination and/or infection during pregnancy and...
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Anti-drug Antibody Magnitude and Clinical Relevance Using Signal to Noise (S/N): Bococizumab Case Study
Historically, the biopharmaceutical industry has used titer to characterize the magnitude of an anti-drug antibody (ADA) response. While reporting...
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Recognition of Immunoreactive Proteins in Leishmania infantum Amastigote-Like and Promastigote Using Sera of Visceral Leishmaniasis Patients: a Preliminary Study
PurposeVisceral leishmaniasis (VL) is a systemic and parasitic disease that is usually fatal if left untreated. VL is endemic in different parts of...
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Proof of stability of an RSV Controlled Human Infection Model challenge agent
In 2018, SGS Belgium NV developed RSV-NICA (Respiratory Syncytial Virus-Nasobronchial Infective Challenge Agent), an RSV type A challenge agent for...
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Harmonization of ANA testing challenge: quantification strategy to accurately predict end-point titers avoiding serial dilution
Despite the advantages of automated systems for antinuclear antibody (ANA) analysis, the prediction of end-point titers avoiding serial dilutions is...
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Serum Anti-interferon-γ Autoantibody Titer as a Potential Biomarker of Disseminated Non-tuberculous Mycobacterial Infection
PurposeIn the past decade, the relationship between naturally occurring interferon-γ-neutralizing autoantibodies (IFNγ-Ab) and disseminated...
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Procedures for the Detection of Wolbachia-Conferred Antiviral Protection in Drosophila melanogaster
Spread of Wolbachia infections in host populations may be enhanced by Wolbachia-conferred protection from viral pathogens. Wolbachia-infected...