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Biosimilars in Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) stands as a major global health concern with limited therapeutic options. Biosimilars are becoming popular in...
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Immunotherapy for Hepatocellular Carcinoma
Background: Hepatocellular carcinoma (HCC), the most common primary malignancy of the liver, is the fifth most common cancer in men and seventh among...
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Liquid Biopsy in Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) is one of the most deadly neoplasms with a poor prognosis. Due to the significant tumor heterogeneity of HCC,...
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Orthotopic Model of Hepatocellular Carcinoma in Mice
Orthotopic models of hepatocellular carcinoma (HCC) consist in the implantation of tumor cells into the liver by direct intrahepatic injection. In...
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Macrophage metabolism, phenotype, function, and therapy in hepatocellular carcinoma (HCC)
The pivotal role of the tumor microenvironment (TME) in the initiation and advancement of hepatocellular carcinoma (HCC) is widely acknowledged, as...
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DEN-Induced Hepatocellular Carcinoma in Animal Model
Cancer is a major cause of death both in developed and develo** countries. Among the various types of cancers, primary liver cancer represents...
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TEP SNORD12B, SNORA63, and SNORD14E as novel biomarkers for hepatitis B virus-related hepatocellular carcinoma (HBV-related HCC)
PurposeThe alterations of RNA profile in tumor-educated platelets (TEPs) have been described as a novel biosource for cancer diagnostics. This study...
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Drug Resistance in Hepatocellular Carcinoma
At present, the burden of cancer morbidity and mortality is increasing all over the world. Among all kinds of cancer, primary liver cancer is...
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BMP4 upregulates glycogen synthesis through the SMAD/SLC2A1 (GLUT1) signaling axis in hepatocellular carcinoma (HCC) cells
BackgroundExcessive hepatic glycogen accumulation benefits tumorigenesis and cancer cell survival. We previously reported that BMP4 has the strongest...
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Fibrosis and Immunotherapy in Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) is difficult-to-treat cancer, despite great advances in systemic therapy, with a median survival of 6–20 months, due...
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Synbiotics in Hepatocellular Carcinoma
Cancer is a deadly disease that affect a wide range of population worldwide. It is accounting for nearly 10 million deaths in 2020, or nearly one in...
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A randomised controlled trial of Standard Of Care versus RadioAblaTion in Early Stage HepatoCellular Carcinoma (SOCRATES HCC)
BackgroundTherapeutic options for early-stage hepatocellular carcinoma (HCC) in individual patients can be limited by tumor and location, liver...
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Surveillance and treatment of primary hepatocellular carcinoma (aka. STOP HCC): protocol for a prospective cohort study of high-risk patients for HCC using GALAD-score
BackgroundVietnam and Saudi Arabia have high disease burden of primary hepatocellular carcinoma (HCC). Early detection in asymptomatic patients at...
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A Mouse Model of Hepatocellular Carcinoma Induced by Streptozotocin and High-Fat Diet
Hepatocellular carcinoma (HCC) is the most common type of liver cancer and the second most common cause of cancer-related death. HCC is associated to...
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Hepatocellular carcinoma immune prognosis score predicts the clinical outcomes of hepatocellular carcinoma patients receiving immune checkpoint inhibitors
ObjectiveThe predictive biomarkers of immune checkpoint inhibitors (ICIs) in hepatocellular carcinoma (HCC) still need to be further explored. This...
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Mongolian HCC vs. Caucasian HCC: The Metabolic Reprogramming Process in Mongolian HCC is an Interesting Difference
Racial/ethnic and region disparities in incidence and mortality are obviously in liver cancer. Mongolia has the highest reported incidence and...
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Perspectives in Biochemical Staging of Hepatocellular Carcinoma Over the Current Microscopical Methodology
Hepatocellular carcinoma (HCC) is considered the third main cause of cancer-related deaths globally. Comparing with other tumors, survival of HCC...
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Interferon-induced transmembrane protein 3 in hepatocellular carcinoma patients
ObjectiveThe study aimed to investigate the over expression of IFITM3 in hepatocellular carcinoma Egyptian patients.
BackgroundHepatocellular...
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Effectiveness of cannabidiol (CBD) on histopathological changes and gene expression in hepatocellular carcinoma (HCC) model in male rats: the role of Hedgehog (Hh) signaling pathway
The third most prevalent malignancy to cause mortality is hepatocellular carcinoma (HCC). The Hedgehog (Hh) signaling pathway is activated by binding...
