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Inhibition of nuclear factor (erythroid-derived 2)-like 2 promotes hepatic progenitor cell activation and differentiation
The stem cell ability to self-renew and lead regeneration relies on the balance of complex signals in their microenvironment. The identification of...
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Mesenchymal stromal cells in hepatic fibrosis/cirrhosis: from pathogenesis to treatment
Hepatic fibrosis/cirrhosis is a significant health burden worldwide, resulting in liver failure or hepatocellular carcinoma (HCC) and accounting for...
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Hepatocyte-derived VEGFA accelerates the progression of non-alcoholic fatty liver disease to hepatocellular carcinoma via activating hepatic stellate cells
Non-alcoholic fatty liver disease (NAFLD) is emerging as an epidemic risk factor for hepatocellular carcinoma (HCC). The progression of NAFLD to HCC...
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Hepatocyte-specific Prominin-1 protects against liver injury-induced fibrosis by stabilizing SMAD7
Prominin-1 (PROM1), also known as CD133, is expressed in hepatic progenitor cells (HPCs) and cholangiocytes of the fibrotic liver. In this study, we...
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Clonorchis sinensis infection contributes to hepatocellular carcinoma progression in rat
Clono rchis sinensis ( C. sinensis ) infection is a risk factor for cholangiocarcinoma. Whether it also contributes to the development of hepatocellular...
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The Expression of Non B Cell-Derived Immunoglobulins
Although V(D)J recombination and immunoglobulin (Ig) production are traditionally recognised to occur only in B lymphocytes and plasma cells, the...
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Current view of liver cancer cell-of-origin and proposed mechanisms precluding its proper determination
Hepatocellular carcinoma and intrahepatic cholangiocarcinoma are devastating primary liver cancers with increasing prevalence in many parts of the...
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BRAFV600E-induced senescence drives Langerhans cell histiocytosis pathophysiology
Langerhans cell histiocytosis (LCH) is a potentially fatal condition characterized by granulomatous lesions with characteristic clonal mononuclear...
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Effects of fine particulate matter on bone marrow-conserved hematopoietic and mesenchymal stem cells: a systematic review
The harmful effects of fine particulate matter ≤2.5 µm in size (PM 2.5 ) on human health have received considerable attention. However, while the...
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Role of the Hippo pathway in liver regeneration and repair: recent advances
Although the signaling pathways involved in normal liver regeneration have been well characterized, less has been done for livers affected by chronic...
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Targeted blocking of CCR2 and CXCR2 improves the efficacy of transarterial chemoembolization of hepatocarcinoma
BackgroundTransarterial chemoembolization (TACE) has been shown to prolong survival in patients with unresectable hepatocellular carcinoma (HCC);...
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Pre-Metastatic Niche: Communication Between Local and Distal Onco-Spheres
The pre-metastatic niche (PMN) is a complex process of the “seed and soil” compatibility. The PMN microenvironment is formed by the influence of...
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Stem Cell Culture and Its Applications
Cells are the structural and functional unit of life. The dynamics of life encompass the continuous interaction of the cells with the environment and...
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Hepatic macrophages in liver homeostasis and diseases-diversity, plasticity and therapeutic opportunities
Macrophages, which are key cellular components of the liver, have emerged as essential players in the maintenance of hepatic homeostasis and in...
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Autophagy in Stem Cell Maintenance and Differentiation
AutophagyAutophagy is one of the intracellular machinery for maintaining organelle as well as physiological homeostasis in cells by clearance of...
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Key role of interferon regulatory factor 1 (IRF-1) in regulating liver disease: progress and outlook
Interferon regulatory factor 1 (IRF-1) is a member of the IRF family. It is the first transcription factor to be identified that could bind to the...
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Sesamol protects against liver fibrosis induced in rats by modulating lysophosphatidic acid receptor expression and TGF-β/Smad3 signaling pathway
The present study aimed to investigate the hepatoprotective effect of sesamol (SML), a nutritional phenolic compound obtained from sesame seeds, in...
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Atypical cholangiocytes derived from hepatocyte-cholangiocyte transdifferentiation mediated by COX-2: a kind of misguided liver regeneration
BackgroundHepatocyte-cholangiocyte transdifferentiation (HCT) is a potential origin of proliferating cholangiocytes in liver regeneration after...
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Cancer and Immunology – The Homeostasis Dance
T cell response by immune system is one step of the cancer-immunity cycle, critically responsible for maintenance of preventing autoimmunity. The...
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Hepatocyte-specific HDAC3 ablation promotes hepatocellular carcinoma in females by suppressing Foxa1/2
BackgroundHepatocellular carcinoma (HCC), the most common primary liver cancer, prevails mainly in males and has long been attributed to androgens...
