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The expression of CD86 in CD3+CD56+ NKT cells is associated with the occurrence and prognosis of sepsis-associated encephalopathy in sepsis patients: a prospective observational cohort study
The role of CD3 + CD56 + natural killer T (NKT) cells and its co-signaling molecules in patients with sepsis-associated encephalopathy (SAE) is unknown....
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Isolation and Characterization Methods of Human Invariant NKT Cells
Natural killer T cells (NKT) are abundant in the hepatic sinuses and account for about 20–50% of rat liver lymphocytes. Type I or invariant NKT cells...
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Vsig4+ resident single-Kupffer cells improve hepatic inflammation and fibrosis in NASH
BackgroundThe role of macrophages in the pathogenesis of nonalcoholic steatohepatitis (NASH) is complex and unclear.
MethodsSingle-cell RNA...
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Single-cell RNA sequencing reveals a peripheral landscape of immune cells in Schistosomiasis japonica
BackgroundSchistosomiasis, also known as bilharzia, is a devastating parasitic disease. This progressive and debilitating helminth disease is often...
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Sex-based differences in natural killer T cell-mediated protection against diet-induced steatohepatitis in Balb/c mice
BackgroundMetabolic dysfunction-associated steatotic liver disease (MASLD) is prevalent in Western countries, evolving into metabolic...
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Control of the Development, Distribution, and Function of Innate-Like Lymphocytes and Innate Lymphoid Cells by the Tissue Microenvironment
Recently, considerable attention has been directed toward innate-like T cells (ITCs) and innate lymphoid cells (ILCs) owing to their indispensable...
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C–C chemokine receptor 5 is essential for conventional NK cell trafficking and liver injury in a murine hepatitis virus-induced fulminant hepatic failure model
BackgroundPrevious studies have demonstrated that natural killer (NK) cells migrated into the liver from peripheral organs and exerted cytotoxic...
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Aberrant cholesterol metabolic signaling impairs antitumor immunosurveillance through natural killer T cell dysfunction in obese liver
Obesity is a major risk factor for cancers including hepatocellular carcinoma (HCC) that develops from a background of non-alcoholic fatty liver...
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iNKT17 cells play a pathogenic role in ethinylestradiol-induced cholestatic hepatotoxicity
IL-17 is closely associated with inflammation in intrahepatic cholestasis (IHC). Targeting IL-17 ameliorates IHC in mice. Invariant natural killer T...
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Immunological characteristics of CD103+CD8+ Tc cells in the liver of C57BL/6 mouse infected with plasmodium NSM
CD103 is an important marker of tissue-resident memory T cells (TRM) which play important roles in fighting against infection. However, the...
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Regulation of Cancer Development and Evolution by Innate Lymphoid Cells
Immune surveillance mechanisms are essential for the identification and elimination of altered cells that, left unchecked, may give rise to cancer....
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Mesenchymal stem cells-based therapy in liver diseases
Multiple immune cells and their products in the liver together form a complex and unique immune microenvironment, and preclinical models have...
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Polarized Th2 cells attenuate high-fat-diet induced obesity through the suppression of lipogenesis
Immune cells, such as macrophages, B cells, neutrophils and T cell subsets, have been implicated in the context of obesity. However, the specific...
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Myeloid-Derived Suppressor Cells and Cancer Metastasis
Myeloid-derived suppressor cells (MDSCs) are pathologically arisen cells mainly acknowledged for their role in immune suppression. Studies have...
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CCR2+TREM-1+ monocytes promote natural killer T cell dysfunction contributing towards HBV disease progression
Natural killer T (NKT) cells are amongst the most important innate immune cells against hepatitis B virus (HBV) infection. Moreover, previous studies...
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Innate lymphoid cells and innate-like T cells in cancer — at the crossroads of innate and adaptive immunity
Immunotherapies targeting conventional T cells have revolutionized systemic treatment for many cancers, yet only a subset of patients benefit from...
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Receptor-interacting protein kinase-1 ablation in liver parenchymal cells promotes liver fibrosis in murine NASH without affecting other symptoms
Non-alcoholic steatohepatitis (NASH), a chronic liver disease that emerged in industrialized countries, can further progress into liver fibrosis,...
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Th17 cells in the liver: balancing autoimmunity and pathogen defense
In addition to carcinogenesis, T helper 17 (Th17) cells (a subtype of CD4 + T lymphocytes) are involved in the acute, chronic, and cirrhotic phases...
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Conventional type 1 dendritic cells protect against age-related adipose tissue dysfunction and obesity
Conventional dendritic cells (cDCs) scan and integrate environmental cues in almost every tissue, including exogenous metabolic signals. While cDCs...
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Evaluation of the TLR3 involvement during Schistosoma japonicum-induced pathology
BackgroundDespite the functions of TLRs in the parasitic infections have been extensively reported, few studies have addressed the role of TLR3 in...
