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Iron accumulation and its impact on osteoporotic fractures in postmenopausal women
Postmenopausal osteoporosis is a kind of degenerative disease, also described as “invisible killer.” Estrogen is generally considered as the key...
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Fibroblast growth factor 21 (FGF21) attenuates tacrolimus-induced hepatic lipid accumulation through transcription factor EB (TFEB)-regulated lipophagy
Tacrolimus (TAC), also called FK506, is one of the classical immunosuppressants to prevent allograft rejection after liver transplantation. However,...
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Loss of SREBP-1c ameliorates iron-induced liver fibrosis by decreasing lipocalin-2
Sterol regulatory element-binding protein (SREBP)-1c is involved in cellular lipid homeostasis and cholesterol biosynthesis and is highly increased...
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Iron and Multiple Sclerosis
Multiple sclerosis (MS) is a chronic autoimmune neurodegenerative disease followed by demyelination and axonal loss. There had been several reports...
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Iron and Neuro-Cognition
Born as Khem in ancient China, India, and Egypt; chemistry or ALCHEMY has always been there, throughout ancient times- seeking a remedy and...
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The Role of Iron Metabolism in Sepsis-associated Encephalopathy: a Potential Target
Sepsis-associated encephalopathy (SAE) is an acute cerebral dysfunction secondary to infection, and the severity can range from mild delirium to deep...
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Mitochondrial GCN5L1 acts as a novel regulator for iron homeostasis to promote sorafenib sensitivity in hepatocellular carcinoma
BackgroundSorafenib resistance is becoming increasingly common and disadvantageous for hepatocellular carcinoma (HCC) treatment. Ferroptosis is an...
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Ferrous sulfate reverses cerebral metabolic abnormality induced by minimal hepatic encephalopathy
Orally administered ferrous iron was previously reported to significantly improve the cognition and locomotion of patients with minimal hepatic...
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ERRFI1 exacerbates hepatic ischemia reperfusion injury by promoting hepatocyte apoptosis and ferroptosis in a GRB2-dependent manner
BackgroundProgrammed cell death is an important mechanism for the development of hepatic ischemia and reperfusion (IR) injury, and multiple novel...
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The role of iron metabolism in chronic diseases related to obesity
Obesity is one of the major public health problems threatening the world, as well as a potential risk factor for chronic metabolic diseases. There is...
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Accumulated Hepatic Steatosis Grades Predicted by T2*-IDEAL Fat Fraction
Purpose1 H Magnetic resonance spectroscopy (MRS) is currently considered to be the standard for MR-based fat quantification without the need of...
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Fatty liver index (FLI): more than a marker of hepatic steatosis
Fatty liver index (FLI) was developed as a simple and accurate marker of hepatic steatosis. FLI is derived from an algorithm based on body mass...
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Iron porphyrin-mediated production of carbon monoxide from phenylpyruvic acid: from potential therapeutic and diagnostic use to physiological implications
Because of CO’s known endogenous signaling roles and its demonstrated pharmacological activity at low and safe concentrations, there is considerable...
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Ochratoxin A induces hepatic and renal toxicity in mice through increased oxidative stress, mitochondrial damage, and multiple cell death mechanisms
Ochratoxin A (OTA) is a widespread food toxin produced by Aspergillus ochraceus and other molds. In this study, we developed and established acute...
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Measures of Iron Metabolism and Applications to Dietary Patterns
Iron deficiency (ID) remains the most common nutritional disorder worldwide. Although iron is biologically essential, tight regulation of iron...
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The Critical Roleplay of Iron Neurochemistry in Progression of Parkinson’s Disease
Iron’s essential involvement in a variety of neurological diseases, including Parkinson’s disease, has been well recognised. Iron can play an...
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Measures of Iron Metabolism and Applications to Dietary Patterns
Iron deficiency (ID) remains the most common nutritional disorder worldwide. Although iron is biologically essential, tight regulation of iron...
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Targeting NF-κB in Hepatic Ischemia–Reperfusion Alleviation: from Signaling Networks to Therapeutic Targeting
Hepatic ischemia–reperfusion injury (HIRI) is a major complication of liver trauma, resection, and transplantation that can lead to liver dysfunction...
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ACACA reduces lipid accumulation through dual regulation of lipid metabolism and mitochondrial function via AMPK- PPARα- CPT1A axis
BackgroundNon-alcoholic fatty liver disease (NAFLD) is a multifaceted metabolic disorder, whose global prevalence is rapidly increasing. Acetyl CoA...
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Functional metabolomics characterizes the contribution of farnesoid X receptor in pyrrolizidine alkaloid-induced hepatic sinusoidal obstruction syndrome
Consumption of herbal products containing pyrrolizidine alkaloids (PAs) is one of the major causes for hepatic sinusoidal obstruction syndrome...
