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Immunobiology of a rationally-designed AAV2 capsid following intravitreal delivery in mice
Adeno-associated virus serotype 2 (AAV2) is a viral vector that can be used to deliver therapeutic genes to diseased cells in the retina. One...
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Chondroitin Sulphate Proteoglycans in the Tumour Microenvironment
Proteoglycans are macromolecules that are essential for the development of cells, human diseases and malignancies. In particular, chondroitin...
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Markers of endothelial glycocalyx dysfunction in Clarkson disease
BackgroundClarkson disease (monoclonal gammopathy-associated idiopathic systemic capillary leak syndrome, ISCLS) is a rare idiopathic condition...
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Role of angiotensin II in cellular entry and replication of dengue virus
Previous studies have demonstrated the relevance of several soluble molecules in the pathogenesis of dengue. In this regard, a possible role for...
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Pharmaceutics Informatics: Bio/Chemoinformatics in Drug Delivery
Whilst bioinformatics deals with the biological receptors and proteins (biological macromolecules) and their manipulation, the chemoinformatics is...
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On the origin and development of glioblastoma: multifaceted role of perivascular mesenchymal stromal cells
Glioblastoma, IDH wild-type is the most common and aggressive form of glial tumors. The exact mechanisms of glioblastoma oncogenesis, including the...
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The medaka mutant deficient in eyes shut homolog exhibits opsin transport defects and enhanced autophagy in retinal photoreceptors
Eyes shut homolog ( EYS ) encodes a proteoglycan and the human mutation causes retinitis pigmentosa type 25 (RP25) with progressive retinal...
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A Rich Bag of Goodies - The Human Body as a Source of Nutrients
The earliest traumatic event in my life I can remember occurred when I overheard my sisters ask my mother what they were made of. They were told...
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Microglial Uptake of Extracellular Tau by Actin-Mediated Phagocytosis
Microglia are scavengers of the brain environment that clear dead cells, debris, and microbes. In Alzheimer’s disease, microglia get activated to...
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Lectures 11 and 12: Urinary (Renal) System
Almost 12% of Australia’s population has chronic kidney disease (CKD). In 2020-2021, haemodialysis treatment for end-stage kidney disease (ESKD) was...
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The Role of Glypican-1 in the Tumour Microenvironment
Glypican-1 (GPC-1) is a cell surface heparan sulphate proteoglycan that is critical during normal development, but which is not required for normal...
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Heparanase and the hallmarks of cancer
Heparanase is the only mammalian enzyme that cleaves heparan sulphate, an important component of the extracellular matrix. This leads to the...
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Impaired angiogenesis in ageing: the central role of the extracellular matrix
Each step in angiogenesis is regulated by the extracellular matrix (ECM). Accumulating evidence indicates that ageing-related changes in the ECM...
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Circulating biosignatures in multiple myeloma and their role in multidrug resistance
A major obstacle to chemotherapeutic success in cancer treatment is the development of drug resistance. This occurs when a tumour fails to reduce in...
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Marine Bioprospecting for the Treatment of Human Parasitic Diseases
This chapter provides information on sulfated polysaccharides (SPS), which are found in marine hydrobionts including algae and invertebrates that may...
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A century of exercise physiology: lung fluid balance during and following exercise
PurposeThis review recalls the principles developed over a century to describe trans-capillary fluid exchanges concerning in particular the lung...
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The impact of genetic manipulation of laminin and integrins at the blood–brain barrier
Blood vessels in the central nervous system (CNS) are unique in having high electrical resistance and low permeability, which creates a selective...
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The extracellular matrix alteration, implication in modulation of drug resistance mechanism: friends or foes?
The extracellular matrix (ECM) is an important component of the tumor microenvironment (TME), having several important roles related to the hallmarks...
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Meta analysis of bioactive compounds, miRNA, siRNA and cell death regulators as sensitizers to doxorubicin induced chemoresistance
Cancer has presented to be the most challenging disease, contributing to one in six mortalities worldwide. The current treatment regimen involves...
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Japanese Encephalitis Virus-Infected Cells
RNA virus infections have been a leading cause of pandemics. Aided by global warming and increased connectivity, their threat is likely to increase...