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Tumor cell-induced platelet aggregation accelerates hematogenous metastasis of malignant melanoma by triggering macrophage recruitment
BackgroundTumor cell-induced platelet aggregation (TCIPA) is not only a recognized mechanism for paraneoplastic thrombocytosis but also a potential...
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The role of tumor-platelet interplay and micro tumor thrombi during hematogenous tumor metastasis
BackgroundIn addition to their pivotal roles in coagulation and thrombosis, platelets are crucial in tumor progression, with plenty of clinical and...
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PD-L1 blockade exhibits anti-tumor effect on brain metastasis by activating CD8+ T cells in hematogenous metastasis model with lymphocyte infusion
Brain metastases are common complication in cancer patients. Immune checkpoint inhibitors show therapeutic benefits also in patients with central...
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Platelets induce CD39 expression in tumor cells to facilitate tumor metastasis
BackgroundTumor cells continue to evolve the metastatic potential in response to signals provided by the external microenvironment during metastasis....
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Invasion and Metastasis
This chapter delineates processes, molecules, and interactions contributing to invasion and metastasis, the most defining properties of malignancy....
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Cancer Stem Cells and Metastasis
Metastasis stands to remain as the primary challenge in managing patients outcome. In recent years, research has shifted toward cancer stem cells...
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Introduction on Cancerous Cells and Metastasis
The diffusion of cancer cells from the primary tumor site into a secondary organ of the body is called metastasis. Metastasis is a feature of...
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Metastasis and Cachexia
In this chapter, we will understand that malignant primary tumors become dangerous when angiogenesis allows their massive growth and in particular...
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The Role of Exosomes in Tumor Metastasis
Exosomes, extracellular vesicles featuring phospholipid bilayers, play essential roles in cell–cell communication; tumor microenvironment (TME)...
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Animal Models for Bone Metastasis Study
Cancer-mediated death is promoted by the process of metastasis. Often, bone is the preferred site of metastasis. The process of metastasis at the...
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Liposarcoma Metastasis
Soft tissue sarcomas are rare tumors originating from mesodermal tissues (fat, muscle connective tissue, and vessels). In-depth molecular analysis...
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Tumor microenvironment in ovarian cancer peritoneal metastasis
Ovarian cancer (OC) is one of the most common gynecological malignancies with high morbidity and mortality. The peritoneum is one of the most common...
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Cancer metastasis through the lymphatic versus blood vessels
Whether cancer cells metastasize from the primary site to the distant sites via the lymphatic vessels or the blood vessels directly into the...
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The path to leptomeningeal metastasis
The leptomeninges, the cerebrospinal-fluid-filled tissues surrounding the central nervous system, play host to various pathologies including...
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Biomarkers in Colon Cancer Metastasis
Globally, colorectal malignancies (CRC) continue to be one of the leading causes of cancer-related fatalities. Despite improvements in our...
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Urologic Cancer and the First Patterns of Metastasis
In this chapter we will describe the patterns of metastasis for two of the most common genitourinary malignancies, prostate cancer and bladder...
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The impact of AMIGO2 on prognosis and hepatic metastasis in gastric cancer patients
BackgroundGastric cancer (GC) is one of the most common malignancies, and the liver is the most common site of hematogenous metastasis of GC. AMIGO2...
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Gene signatures of circulating breast cancer cell models are a source of novel molecular determinants of metastasis and improve circulating tumor cell detection in patients
BackgroundProgression to stage IV disease remains the main cause of breast cancer-related deaths. Increasing knowledge on the hematogenous phase of...
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Single-cell transcriptomics provide insight into metastasis-related subsets of breast cancer
Breast cancer metastasis is a complex, multi-step process, with high cellular heterogeneity between primary and metastatic breast cancer, and more...
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Pathologic Assessment of Lymph Node Metastasis
The pathologic assessment and evaluation of lymph node status plays a central role in the diagnosis, staging, and management of most malignancies....